Entity Details

Primary name I27RA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6UWB1
EntryNameI27RA_HUMAN
FullNameInterleukin-27 receptor subunit alpha
TaxID9606
Evidenceevidence at protein level
Length636
SequenceStatuscomplete
DateCreated2005-03-29
DateModified2021-06-02

Ontological Relatives

GenesIL27RA

GO terms

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GOName
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0002829 negative regulation of type 2 immune response
GO:0004888 transmembrane signaling receptor activity
GO:0004896 cytokine receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0009897 external side of plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019955 cytokine binding
GO:0032700 negative regulation of interleukin-17 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0042022 interleukin-12 receptor complex
GO:0042104 positive regulation of activated T cell proliferation
GO:0043235 receptor complex
GO:0045509 interleukin-27 receptor activity
GO:0048302 regulation of isotype switching to IgG isotypes
GO:0050830 defense response to Gram-positive bacterium
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070757 interleukin-35-mediated signaling pathway
GO:0072536 interleukin-23 receptor complex
GO:2000317 negative regulation of T-helper 17 type immune response
GO:2000408 negative regulation of T cell extravasation

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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