Entity Details

Primary name TPH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IWU9
EntryNameTPH2_HUMAN
FullNameTryptophan 5-hydroxylase 2
TaxID9606
Evidenceevidence at protein level
Length490
SequenceStatuscomplete
DateCreated2003-05-09
DateModified2021-06-02

Ontological Relatives

GenesTPH2

GO terms

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GOName
GO:0004510 tryptophan 5-monooxygenase activity
GO:0005506 iron ion binding
GO:0005829 cytosol
GO:0007623 circadian rhythm
GO:0009072 aromatic amino acid family metabolic process
GO:0014823 response to activity
GO:0031667 response to nutrient levels
GO:0042427 serotonin biosynthetic process
GO:0043005 neuron projection
GO:0043627 response to estrogen
GO:0046219 indolalkylamine biosynthetic process
GO:0051384 response to glucocorticoid
GO:0051592 response to calcium ion
GO:0071285 cellular response to lithium ion

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001273 Aromatic amino acid hydroxylaseFamilyFamily
IPR002912 ACT domainDomainDomain
IPR005963 Tryptophan 5-monooxygenaseFamilyFamily
IPR018301 Aromatic amino acid hydroxylase, iron/copper binding siteSiteBinding site
IPR019773 Tyrosine 3-monooxygenase-likeFamilyFamily
IPR019774 Aromatic amino acid hydroxylase, C-terminalDomainDomain
IPR036329 Aromatic amino acid monoxygenase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036951 Aromatic amino acid hydroxylase superfamilyFamilyHomologous superfamily
IPR041904 Tryptophan 5-hydroxylase, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00150 TryptophanDrugbanksmall molecule
DB12095 Telotristat ethylDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TPH2_HUMAN1433E_HUMANMINT17973628 details