Entity Details

Primary name DLL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00548
EntryNameDLL1_HUMAN
FullNameDelta-like protein 1
TaxID9606
Evidenceevidence at protein level
Length723
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesDLL1

GO terms

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GOName
GO:0001709 cell fate determination
GO:0001756 somitogenesis
GO:0001757 somite specification
GO:0001947 heart looping
GO:0002315 marginal zone B cell differentiation
GO:0003323 type B pancreatic cell development
GO:0005112 Notch binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005912 adherens junction
GO:0007219 Notch signaling pathway
GO:0007368 determination of left/right symmetry
GO:0007386 compartment pattern specification
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009954 proximal/distal pattern formation
GO:0010628 positive regulation of gene expression
GO:0014002 astrocyte development
GO:0014807 regulation of somitogenesis
GO:0016324 apical plasma membrane
GO:0021510 spinal cord development
GO:0021688 cerebellar molecular layer formation
GO:0021693 cerebellar Purkinje cell layer structural organization
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030155 regulation of cell adhesion
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030957 Tat protein binding
GO:0031410 cytoplasmic vesicle
GO:0032693 negative regulation of interleukin-10 production
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035265 organ growth
GO:0040008 regulation of growth
GO:0045121 membrane raft
GO:0045596 negative regulation of cell differentiation
GO:0045605 negative regulation of epidermal cell differentiation
GO:0045608 negative regulation of inner ear auditory receptor cell differentiation
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045747 positive regulation of Notch signaling pathway
GO:0045807 positive regulation of endocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046331 lateral inhibition
GO:0048630 skeletal muscle tissue growth
GO:0048631 regulation of skeletal muscle tissue growth
GO:0048633 positive regulation of skeletal muscle tissue growth
GO:0048665 neuron fate specification
GO:0048839 inner ear development
GO:0050767 regulation of neurogenesis
GO:0051302 regulation of cell division
GO:0060041 retina development in camera-type eye
GO:0060042 retina morphogenesis in camera-type eye
GO:0060853 Notch signaling pathway involved in arterial endothelial cell fate commitment
GO:0070986 left/right axis specification
GO:0072006 nephron development
GO:0072014 proximal tubule development
GO:0072070 loop of Henle development
GO:0072583 clathrin-dependent endocytosis
GO:0097009 energy homeostasis
GO:0097102 endothelial tip cell fate specification
GO:0097110 scaffold protein binding
GO:0097150 neuronal stem cell population maintenance
GO:0098773 skin epidermis development
GO:1900746 regulation of vascular endothelial growth factor signaling pathway
GO:1903672 positive regulation of sprouting angiogenesis
GO:2000726 negative regulation of cardiac muscle cell differentiation

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell junction
Membrane raft

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001774 Delta/Serrate/lag-2 (DSL) proteinDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011651 Notch ligand, N-terminal domainDomainDomain
IPR013032 EGF-like, conserved siteSiteConserved site
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site

Diseases

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