Entity Details

Primary name NICA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92542
EntryNameNICA_HUMAN
FullNameNicastrin
TaxID9606
Evidenceevidence at protein level
Length709
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesNCSTN

GO terms

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GOName
GO:0002262 myeloid cell homeostasis
GO:0004175 endopeptidase activity
GO:0005739 mitochondrion
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007212 dopamine receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007220 Notch receptor processing
GO:0007611 learning or memory
GO:0008021 synaptic vesicle
GO:0010008 endosome membrane
GO:0010950 positive regulation of endopeptidase activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0021549 cerebellum development
GO:0022010 central nervous system myelination
GO:0030534 adult behavior
GO:0030674 protein-macromolecule adaptor activity
GO:0031293 membrane protein intracellular domain proteolysis
GO:0034205 amyloid-beta formation
GO:0035333 Notch receptor processing, ligand-dependent
GO:0035577 azurophil granule membrane
GO:0042098 T cell proliferation
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042982 amyloid precursor protein metabolic process
GO:0042983 amyloid precursor protein biosynthetic process
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process
GO:0042987 amyloid precursor protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043312 neutrophil degranulation
GO:0048013 ephrin receptor signaling pathway
GO:0050673 epithelial cell proliferation
GO:0051117 ATPase binding
GO:0051402 neuron apoptotic process
GO:0070062 extracellular exosome
GO:0070765 gamma-secretase complex
GO:0070851 growth factor receptor binding
GO:0071277 cellular response to calcium ion
GO:0099056 integral component of presynaptic membrane
GO:1900271 regulation of long-term synaptic potentiation
GO:1990000 amyloid fibril formation
GO:1990926 short-term synaptic potentiation

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle membrane
Melanosome
Membrane

Domains

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DomainNameCategoryType
IPR008710 NicastrinFamilyFamily
IPR041084 Nicastrin, small lobeDomainDomain

Diseases

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