Entity Details

Primary name SFRP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92765
EntryNameSFRP3_HUMAN
FullNameSecreted frizzled-related protein 3
TaxID9606
Evidenceevidence at protein level
Length325
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesFRZB

GO terms

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GOName
GO:0001501 skeletal system development
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0008285 negative regulation of cell population proliferation
GO:0010721 negative regulation of cell development
GO:0014033 neural crest cell differentiation
GO:0016020 membrane
GO:0017147 Wnt-protein binding
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0043065 positive regulation of apoptotic process
GO:0045600 positive regulation of fat cell differentiation
GO:0060029 convergent extension involved in organogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0061037 negative regulation of cartilage development
GO:0061053 somite development
GO:0070367 negative regulation of hepatocyte differentiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001134 Netrin domainDomainDomain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR015526 Frizzled/secreted frizzled-related proteinFamilyFamily
IPR018933 Netrin module, non-TIMP typeDomainDomain
IPR020067 Frizzled domainDomainDomain
IPR026556 Secreted frizzled-related protein 3FamilyFamily
IPR035813 Secreted frizzled-related protein 3, NTR domainDomainDomain
IPR036790 Frizzled cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR041759 SFRP3, cysteine-rich domainDomainDomain

Diseases

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