Entity Details

Primary name TNF11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14788
EntryNameTNF11_HUMAN
FullNameTumor necrosis factor ligand superfamily member 11
TaxID9606
Evidenceevidence at protein level
Length317
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesTNFSF11

GO terms

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GOName
GO:0001503 ossification
GO:0002158 osteoclast proliferation
GO:0002548 monocyte chemotaxis
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0007257 obsolete activation of JUN kinase activity
GO:0010628 positive regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0019722 calcium-mediated signaling
GO:0030316 osteoclast differentiation
GO:0032813 tumor necrosis factor receptor superfamily binding
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033598 mammary gland epithelial cell proliferation
GO:0034112 positive regulation of homotypic cell-cell adhesion
GO:0036035 osteoclast development
GO:0038001 paracrine signaling
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0044691 tooth eruption
GO:0045453 bone resorption
GO:0045672 positive regulation of osteoclast differentiation
GO:0045780 positive regulation of bone resorption
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0050870 positive regulation of T cell activation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051466 positive regulation of corticotropin-releasing hormone secretion
GO:0051897 positive regulation of protein kinase B signaling
GO:0055074 calcium ion homeostasis
GO:0060749 mammary gland alveolus development
GO:0070371 ERK1 and ERK2 cascade
GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847 TNFSF11-mediated signaling pathway
GO:0071848 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
GO:1902533 positive regulation of intracellular signal transduction
GO:1904616 regulation of actin binding
GO:1990830 cellular response to leukemia inhibitory factor
GO:2001206 positive regulation of osteoclast development

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR006052 Tumour necrosis factor domainDomainDomain
IPR008983 Tumour necrosis factor-like domain superfamilyFamilyHomologous superfamily
IPR017355 Tumour necrosis factor ligand 10/11FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00480 LenalidomideDrugbanksmall molecule
DB06511 AMGN-0007Drugbankbiotech
DB06643 DenosumabDrugbankbiotech
DB11582 ThiocolchicosideDrugbanksmall molecule

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
TNF11_HUMANBBS10_HUMANBioGRID, MINT21900206 details
TNF11_HUMANPXL2B_HUMANBioGRID, MINT21900206 details
TNF11_HUMANDDAH2_HUMANBioGRID, MINT21900206 details
TNF11_HUMANEF1A1_HUMANBioGRID, MINT21900206 details
TNF11_HUMANEZH2_HUMANBioGRID, MINT21900206 details
TNF11_HUMANCE126_HUMANBioGRID, MINT21900206 details
TNF11_HUMANLMO4_HUMANBioGRID, MINT21900206 details
TNF11_HUMANMBTP1_HUMANBioGRID, MINT21900206 details
TNF11_HUMANMED24_HUMANBioGRID, MINT21900206 details
TNF11_HUMANPHAX_HUMANBioGRID, MINT21900206 details
TNF11_HUMANPLK1_HUMANBioGRID, MINT21900206 details
TNF11_HUMANMTMR5_HUMANBioGRID, MINT21900206 details
TNF11_HUMANU1SBP_HUMANBioGRID, MINT21900206 details
TNF11_HUMANTMOD3_HUMANBioGRID, MINT21900206 details
TNF11_HUMANTRM2A_HUMANBioGRID, MINT21900206 details
TNF11_HUMANNIPA_HUMANBioGRID, MINT21900206 details
TNF11_HUMANTSG6_HUMANIntAct18586671 details
TNF11_HUMANUPK2_HUMANBioGRID, IntAct32296183 details
TNF11_HUMANOLFM4_HUMANBioGRID, IntAct32296183 details
TNF11_HUMANTR11B_HUMANBioGRID, HPRD, IntAct12221720 22664871 9520411 details
TNF11_HUMANTNR11_HUMANHPRD, IntAct22664871 9367155 details
TNF11_HUMANSRC_HUMANBioGRID10635328 details
TNF11_HUMANMK01_HUMANHPRD10635328 details
TNF11_HUMANMK08_HUMANHPRD9396779 details
TNF11_HUMANMK03_HUMANHPRD10635328 details
TNF11_HUMANTRAF6_HUMANHPRD10635328 details
TNF11_HUMANTNF11_HUMANHPRD10635328 details
TNF11_HUMANMMP3_HUMANHPRD15894268 details
TNF11_HUMANMMP7_HUMANHPRD15894268 details
TNF11_HUMANMMP1_HUMANHPRD10224132 details
TNF11_HUMANADA17_HUMANHPRD10224132 details
TNF11_HUMANIKBA_HUMANHPRD10635328 details
TNF11_HUMANNFKB1_HUMANHPRD10635328 details
TNF11_HUMANAKT1_HUMANHPRD10635328 details