Entity Details

Primary name MARK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96L34
EntryNameMARK4_HUMAN
FullNameMAP/microtubule affinity-regulating kinase 4
TaxID9606
Evidenceevidence at protein level
Length752
SequenceStatuscomplete
DateCreated2003-02-28
DateModified2021-06-02

Ontological Relatives

GenesMARK4

GO terms

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GOName
GO:0000226 microtubule cytoskeleton organization
GO:0000930 gamma-tubulin complex
GO:0001578 microtubule bundle formation
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007399 nervous system development
GO:0008017 microtubule binding
GO:0015630 microtubule cytoskeleton
GO:0030425 dendrite
GO:0030496 midbody
GO:0035556 intracellular signal transduction
GO:0036064 ciliary basal body
GO:0043005 neuron projection
GO:0043015 gamma-tubulin binding
GO:0043068 positive regulation of programmed cell death
GO:0043130 ubiquitin binding
GO:0044782 cilium organization
GO:0045724 positive regulation of cilium assembly
GO:0046605 regulation of centrosome cycle
GO:0048156 tau protein binding
GO:0050321 tau-protein kinase activity
GO:0051301 cell division
GO:0097711 ciliary basal body-plasma membrane docking
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904781 positive regulation of protein localization to centrosome

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001772 Kinase associated domain 1 (KA1)DomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015940 Ubiquitin-associated domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR028375 KA1 domain/Ssp2, C-terminalFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
MARK4_HUMANUSP9X_HUMANBioGRID, IntAct14676191 18254724 details
MARK4_HUMANKPCI_HUMANBioGRID, HPRD, IntAct14676191 26346160 details
MARK4_HUMANSTK11_HUMANBioGRID, HPRD, IntAct14676191 details
MARK4_HUMANHPS6_HUMANHPRD, IntAct16169070 details
MARK4_HUMANPRIO_HUMANBioGRID, IntAct18482256 details
MARK4_HUMANTAU_HUMANBioGRID, HPRD, IntAct14594945 23666762 details
MARK4_HUMANK1H1_HUMANBioGRID, IntAct25416956 details
MARK4_HUMANAPJ_HUMANBioGRID, MINT28298427 details
MARK4_HUMANAPLP2_HUMANIntAct32814053 details
MARK4_HUMANKC1D_HUMANIntAct32814053 details
MARK4_HUMANLYN_HUMANIntAct32814053 details
MARK4_HUMANA4_HUMANIntAct32814053 details
MARK4_HUMANMTAP2_HUMANBioGRID14594945 details
MARK4_HUMANMAP4_HUMANBioGRID, HPRD14594945 details
MARK4_HUMANHGS_HUMANBioGRID19019082 details
MARK4_HUMANNEDD4_HUMANBioGRID19953087 details
MARK4_HUMANAPRIO_HUMANBioGRID18482256 details
MARK4_HUMANRPTOR_HUMANBioGRID23184942 details
MARK4_HUMANODFP2_HUMANBioGRID23400999 details
MARK4_HUMANHNRPK_HUMANBioGRID25416956 details
MARK4_HUMANKHDR3_HUMANBioGRID25416956 details
MARK4_HUMANMTUS2_HUMANBioGRID25416956 details
MARK4_HUMANK1C40_HUMANBioGRID25416956 details
MARK4_HUMANNT2NC_HUMANBioGRID25416956 details
MARK4_HUMANNT2NA_HUMANBioGRID25416956 details
MARK4_HUMANMED20_HUMANBioGRID32296183 details
MARK4_HUMAN1433F_HUMANBioGRID, HPRD, IntAct14676191 16959763 details
MARK4_HUMANTBG1_HUMANBioGRID, HPRD, IntAct14594945 14676191 details
MARK4_HUMANPAR6G_HUMANIntAct14676191 details
MARK4_HUMAN1433Z_HUMANHPRD, IntAct14676191 16306228 details
MARK4_HUMANMYH9_HUMANBioGRID14594945 details
MARK4_HUMANMYH10_HUMANBioGRID14594945 details
MARK4_HUMANHSP74_HUMANBioGRID14594945 details
MARK4_HUMANACTS_HUMANBioGRID14594945 details
MARK4_HUMANAAPK1_HUMANBioGRID16306228 details
MARK4_HUMANPAR6A_HUMANBioGRID, HPRD14676191 details
MARK4_HUMANNLRP3_HUMANBioGRID31167564 details
MARK4_HUMANKPCG_HUMANHPRD14676191 details
MARK4_HUMANTBB2A_HUMANHPRD14594945 details
MARK4_HUMAN1433B_HUMANHPRD14676191 details
MARK4_HUMANTBA4A_HUMANHPRD14594945 details
MARK4_HUMANMARK4_HUMANHPRD17192257 details