Entity Details

Primary name NODAL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96S42
EntryNameNODAL_HUMAN
FullNameNodal homolog
TaxID9606
Evidenceevidence at protein level
Length347
SequenceStatuscomplete
DateCreated2003-01-10
DateModified2021-06-02

Ontological Relatives

GenesNODAL

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001831 trophectodermal cellular morphogenesis
GO:0001842 neural fold formation
GO:0001889 liver development
GO:0001890 placenta development
GO:0001892 embryonic placenta development
GO:0001893 maternal placenta development
GO:0001944 vasculature development
GO:0001947 heart looping
GO:0002085 inhibition of neuroepithelial cell differentiation
GO:0005125 cytokine activity
GO:0005615 extracellular space
GO:0007420 brain development
GO:0008083 growth factor activity
GO:0009880 embryonic pattern specification
GO:0010085 polarity specification of proximal/distal axis
GO:0010470 regulation of gastrulation
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010721 negative regulation of cell development
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016015 morphogen activity
GO:0019827 stem cell population maintenance
GO:0022409 positive regulation of cell-cell adhesion
GO:0030509 BMP signaling pathway
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0033505 floor plate morphogenesis
GO:0035987 endodermal cell differentiation
GO:0042074 cell migration involved in gastrulation
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048327 axial mesodermal cell fate specification
GO:0048382 mesendoderm development
GO:0048546 digestive tract morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048859 formation of anatomical boundary
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060136 embryonic process involved in female pregnancy
GO:0060137 maternal process involved in parturition
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060395 SMAD protein signal transduction
GO:0060460 left lung morphogenesis
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0060802 epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070698 type I activin receptor binding
GO:0090010 transforming growth factor beta receptor signaling pathway involved in primitive streak formation
GO:1900164 nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:1901164 negative regulation of trophoblast cell migration
GO:1901383 negative regulation of chorionic trophoblast cell proliferation
GO:2000036 regulation of stem cell population maintenance

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001839 Transforming growth factor-beta, C-terminalDomainDomain
IPR015615 Transforming growth factor-beta-relatedFamilyFamily
IPR017948 Transforming growth factor beta, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Interactions

5 interactions