Entity Details

Primary name P2RX7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99572
EntryNameP2RX7_HUMAN
FullNameP2X purinoceptor 7
TaxID9606
Evidenceevidence at protein level
Length595
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesP2RX7

GO terms

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GOName
GO:0001530 lipopolysaccharide binding
GO:0001614 purinergic nucleotide receptor activity
GO:0002028 regulation of sodium ion transport
GO:0002931 response to ischemia
GO:0004931 extracellularly ATP-gated cation channel activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005639 integral component of nuclear inner membrane
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007166 cell surface receptor signaling pathway
GO:0007596 blood coagulation
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010628 positive regulation of gene expression
GO:0016020 membrane
GO:0017121 plasma membrane phospholipid scrambling
GO:0019233 sensory perception of pain
GO:0030501 positive regulation of bone mineralization
GO:0032059 bleb
GO:0032060 bleb assembly
GO:0032731 positive regulation of interleukin-1 beta production
GO:0033198 response to ATP
GO:0034767 positive regulation of ion transmembrane transport
GO:0035585 calcium-mediated signaling using extracellular calcium source
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042802 identical protein binding
GO:0043409 negative regulation of MAPK cascade
GO:0045779 negative regulation of bone resorption
GO:0045794 negative regulation of cell volume
GO:0045821 positive regulation of glycolytic process
GO:0046931 pore complex assembly
GO:0051495 positive regulation of cytoskeleton organization
GO:0051709 regulation of killing of cells of other organism
GO:0051899 membrane depolarization
GO:0070588 calcium ion transmembrane transport
GO:0071318 cellular response to ATP
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0098794 postsynapse
GO:1904172 positive regulation of bleb assembly
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR001429 P2X purinoreceptorFamilyFamily
IPR003050 P2X7 purinoceptorFamilyFamily
IPR027309 P2X purinoreceptor extracellular domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01069 PromethazineDrugbanksmall molecule