Entity Details

Primary name E2AK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BQI3
EntryNameE2AK1_HUMAN
FullNameEukaryotic translation initiation factor 2-alpha kinase 1
TaxID9606
Evidenceevidence at protein level
Length630
SequenceStatuscomplete
DateCreated2001-07-11
DateModified2021-06-02

Ontological Relatives

GenesEIF2AK1

GO terms

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GOName
GO:0002526 acute inflammatory response
GO:0004672 protein kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0006909 phagocytosis
GO:0008285 negative regulation of cell population proliferation
GO:0010999 regulation of eIF2 alpha phosphorylation by heme
GO:0020037 heme binding
GO:0030225 macrophage differentiation
GO:0042803 protein homodimerization activity
GO:0045993 negative regulation of translational initiation by iron
GO:0046501 protoporphyrinogen IX metabolic process
GO:0046777 protein autophosphorylation
GO:0046986 negative regulation of hemoglobin biosynthetic process
GO:0055072 iron ion homeostasis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0140467 integrated stress response signaling
GO:0140468 HRI-mediated signaling
GO:1990641 response to iron ion starvation

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule