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Entity Details
Primary name
MKNK1_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
Q9BUB5
EntryName
MKNK1_HUMAN
FullName
MAP kinase-interacting serine/threonine-protein kinase 1
TaxID
9606
Evidence
evidence at protein level
Length
465
SequenceStatus
complete
DateCreated
2003-04-30
DateModified
2021-06-02
Ontological Relatives
Genes
MKNK1
GO terms
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GO
Name
GO:0004674
protein serine/threonine kinase activity
GO:0004683
calmodulin-dependent protein kinase activity
GO:0005516
calmodulin binding
GO:0005524
ATP binding
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0006417
regulation of translation
GO:0006468
protein phosphorylation
GO:0009931
calcium-dependent protein serine/threonine kinase activity
GO:0018105
peptidyl-serine phosphorylation
GO:0035556
intracellular signal transduction
GO:0046777
protein autophosphorylation
GO:0046872
metal ion binding
GO:0106310
protein serine kinase activity
GO:0106311
protein threonine kinase activity
Subcellular Location
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Subcellular Location
Cytoplasm
Nucleus
Domains
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Domain
Name
Category
Type
IPR000719
Protein kinase domain
Domain
Domain
IPR008271
Serine/threonine-protein kinase, active site
Site
Active site
IPR011009
Protein kinase-like domain superfamily
Family
Homologous superfamily
IPR017441
Protein kinase, ATP binding site
Site
Binding site
Diseases
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Drugs
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Drug
Name
Source
Type
DB12010
Fostamatinib
Drugbank
small molecule
Interactions
31 interactions
Interactor
Partner
Sources
Publications
Link
MKNK1_HUMAN
IF4G1_HUMAN
BioGRID, HPRD, MINT
15234964
9878069
details
MKNK1_HUMAN
MK14_HUMAN
BioGRID, HPRD, IntAct
10922375
11157753
20936779
23455922
23602568
26186194
28514442
9155018
details
MKNK1_HUMAN
CBP_HUMAN
BioGRID, IntAct
20936779
details
MKNK1_HUMAN
DNJC7_HUMAN
BioGRID, IntAct
20936779
details
MKNK1_HUMAN
HS90B_HUMAN
BioGRID, IntAct
20936779
details
MKNK1_HUMAN
PRKDC_HUMAN
BioGRID, IntAct
20936779
details
MKNK1_HUMAN
HGS_HUMAN
BioGRID, IntAct
21988832
details
MKNK1_HUMAN
HIPK2_HUMAN
BioGRID, IntAct
21988832
details
MKNK1_HUMAN
RCN3_HUMAN
BioGRID, IntAct
21988832
details
MKNK1_HUMAN
TNIP2_HUMAN
BioGRID, IntAct
21988832
details
MKNK1_HUMAN
ATX3_HUMAN
BioGRID, MINT
21900206
details
MKNK1_HUMAN
DDAH2_HUMAN
BioGRID, MINT
21900206
details
MKNK1_HUMAN
IF4G3_HUMAN
BioGRID, HPRD, MINT
10022874
21900206
9878069
details
MKNK1_HUMAN
PHAX_HUMAN
BioGRID, MINT
21900206
details
MKNK1_HUMAN
UB2D1_HUMAN
BioGRID, MINT
21900206
details
MKNK1_HUMAN
CREM_HUMAN
BioGRID, IntAct
32296183
details
MKNK1_HUMAN
MK01_HUMAN
BioGRID, HPRD, IntAct
10922375
31980649
32296183
9155017
details
MKNK1_HUMAN
OPTN_HUMAN
IntAct
32814053
details
MKNK1_HUMAN
HD_HUMAN
IntAct
32814053
details
MKNK1_HUMAN
ATX1_HUMAN
IntAct
32814053
details
MKNK1_HUMAN
FANCA_HUMAN
BioGRID
14499622
details
MKNK1_HUMAN
MK03_HUMAN
BioGRID, HPRD
9155018
details
MKNK1_HUMAN
SPY2_HUMAN
BioGRID
16479008
details
MKNK1_HUMAN
A4_HUMAN
BioGRID
21832049
details
MKNK1_HUMAN
IF4E_HUMAN
BioGRID, HPRD, MINT
10022874
9155017
9878069
details
MKNK1_HUMAN
PP2AA_HUMAN
MINT
20927323
details
MKNK1_HUMAN
PAK2_HUMAN
BioGRID, HPRD, IntAct
15234964
25241761
details
MKNK1_HUMAN
MKNK1_HUMAN
HPRD, UniProt
31837246
9878069
details
MKNK1_HUMAN
IF4G2_HUMAN
BioGRID, HPRD
9878069
details
MKNK1_HUMAN
PA24A_HUMAN
HPRD
10978317
8636128
9468497
details
MKNK1_HUMAN
MBP_HUMAN
HPRD
9155018
details
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