Entity Details

Primary name SETD2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BYW2
EntryNameSETD2_HUMAN
FullNameHistone-lysine N-methyltransferase SETD2
TaxID9606
Evidenceevidence at protein level
Length2564
SequenceStatuscomplete
DateCreated2006-10-17
DateModified2021-06-02

Ontological Relatives

GenesSETD2

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001763 morphogenesis of a branching structure
GO:0001843 neural tube closure
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0006298 mismatch repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0010793 regulation of mRNA export from nucleus
GO:0016032 viral process
GO:0016279 protein-lysine N-methyltransferase activity
GO:0018023 peptidyl-lysine trimethylation
GO:0018024 histone-lysine N-methyltransferase activity
GO:0018026 peptidyl-lysine monomethylation
GO:0030900 forebrain development
GO:0032465 regulation of cytokinesis
GO:0032727 positive regulation of interferon-alpha production
GO:0034340 response to type I interferon
GO:0034728 nucleosome organization
GO:0035441 cell migration involved in vasculogenesis
GO:0035987 endodermal cell differentiation
GO:0043014 alpha-tubulin binding
GO:0046872 metal ion binding
GO:0046975 histone methyltransferase activity (H3-K36 specific)
GO:0048332 mesoderm morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048863 stem cell differentiation
GO:0048864 stem cell development
GO:0051607 defense response to virus
GO:0060039 pericardium development
GO:0060669 embryonic placenta morphogenesis
GO:0060977 coronary vasculature morphogenesis
GO:0097198 histone H3-K36 trimethylation
GO:0097676 histone H3-K36 dimethylation
GO:1902850 microtubule cytoskeleton organization involved in mitosis
GO:1905634 regulation of protein localization to chromatin

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001202 WW domainDomainDomain
IPR001214 SET domainDomainDomain
IPR003616 Post-SET domainDomainDomain
IPR006560 AWS domainDomainDomain
IPR013257 Set2 Rpb1 interacting domainDomainDomain
IPR035441 TFIIS/LEDGF domain superfamilyFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily
IPR038190 Set2 Rpb1 interacting domain superfamilyFamilyHomologous superfamily
IPR042294 Histone-lysine N-methyltransferase SETD2, animalFamilyFamily
IPR044437 SETD2/Set2, SET domainDomainDomain

Diseases

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