Entity Details

Primary name HDAC3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15379
EntryNameHDAC3_HUMAN
FullNameHistone deacetylase 3
TaxID9606
Evidenceevidence at protein level
Length428
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesHDAC3

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001934 positive regulation of protein phosphorylation
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006325 chromatin organization
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006476 protein deacetylation
GO:0007623 circadian rhythm
GO:0008134 transcription factor binding
GO:0017053 transcription repressor complex
GO:0019216 regulation of lipid metabolic process
GO:0019899 enzyme binding
GO:0030332 cyclin binding
GO:0030522 intracellular receptor signaling pathway
GO:0031398 positive regulation of protein ubiquitination
GO:0031647 regulation of protein stability
GO:0032008 positive regulation of TOR signaling
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032922 circadian regulation of gene expression
GO:0033558 protein deacetylase activity
GO:0042307 positive regulation of protein import into nucleus
GO:0042752 regulation of circadian rhythm
GO:0042826 histone deacetylase binding
GO:0043066 negative regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046329 negative regulation of JNK cascade
GO:0051059 NF-kappaB binding
GO:0051225 spindle assembly
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0071498 cellular response to fluid shear stress
GO:0072686 mitotic spindle
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000286 Histone deacetylase familyFamilyFamily
IPR003084 Histone deacetylaseFamilyFamily
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily
IPR023801 Histone deacetylase domainDomainDomain
IPR037138 Histone deacetylase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02546 VorinostatDrugbanksmall molecule
DB05015 BelinostatDrugbanksmall molecule
DB05223 PracinostatDrugbanksmall molecule
DB06603 PanobinostatDrugbanksmall molecule
DB11830 MocetinostatDrugbanksmall molecule

Interactions

210 interactions

InteractorPartnerSourcesPublicationsLink
HDAC3_HUMANNRIP1_HUMANBioGRID, HPRD, MINT11006275 17053781 21868449 details
HDAC3_HUMANBRMS1_HUMANBioGRID, IntAct16919237 17227585 details
HDAC3_HUMANHDAC9_HUMANBioGRID, HPRD, UniProt10655483 11466315 12590135 details
HDAC3_HUMANHDAC4_HUMANBioGRID, DIP, HPRD, IntAct10220385 10869435 11466315 11804585 17956988 18558095 27684187 31040226 details
HDAC3_HUMANNCOR1_HUMANBioGRID, HPRD, IntAct, UniProt10860984 10944117 11013263 11466315 11509652 11804585 11931768 12628926 14527417 14722073 15601853 16195251 16469706 16917504 16980585 21258344 23752268 29523594 details
HDAC3_HUMANNCOR2_HUMANBioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections, UniProt10809664 10860984 10944117 11013263 11509652 11804585 12205093 12502735 12628926 14527417 15837933 16481466 16924111 16980585 17126328 21258344 21624135 22230954 23752268 24449765 26728228 29523594 details
HDAC3_HUMANLMBL2_HUMANBioGRID, MINT20385135 details
HDAC3_HUMANGPS2_HUMANBioGRID, DIP, HPRD, IntAct, UniProt11931768 16980585 17895379 21258344 23752268 24943844 26186194 28514442 details
HDAC3_HUMANTBL1X_HUMANBioGRID, HPRD, IntAct, UniProt10809664 10944117 11931768 16980585 18202150 21258344 23752268 28348241 details
HDAC3_HUMANPP4C_HUMANBioGRID, HPRD, MINT15805470 details
HDAC3_HUMANANR11_HUMANBioGRID, HPRD, IntAct15184363 23752268 details
HDAC3_HUMANANR12_HUMANBioGRID, IntAct18377363 23752268 details
HDAC3_HUMANDP13A_HUMANBioGRID, IntAct23752268 29523594 details
HDAC3_HUMANTCPA_HUMANBioGRID, IntAct12502735 23752268 details
HDAC3_HUMANTCPE_HUMANBioGRID, HPRD, IntAct12502735 23752268 details
HDAC3_HUMANHDAC7_HUMANBioGRID, HPRD, IntAct11466315 23752268 details
HDAC3_HUMANHIF1N_HUMANBioGRID, HPRD, IntAct11641274 26972000 details
HDAC3_HUMANSNAI1_HUMANBioGRID, IntAct21685935 25314079 details
HDAC3_HUMANCCND1_HUMANBioGRID, DIP, HPRD12048199 15558026 15713663 16461912 20484017 details
HDAC3_HUMANMAGA2_HUMANBioGRID, DIP16847267 details
HDAC3_HUMANGATA3_HUMANBioGRID, DIP17075044 29453984 details
HDAC3_HUMANNR0B2_HUMANBioGRID, DIP15835920 17895379 details
HDAC3_HUMANHDAC3_HUMANBioGRID, DIP, HPRD10655483 10898795 11779848 11804585 14521922 22230954 23752268 25997740 details
HDAC3_HUMANPGK1_HUMANDIP26356530 details
HDAC3_HUMANESR1_HUMANBioGRID, IntAct14722073 16469706 20348541 26487511 31527615 details
HDAC3_HUMANEWS_HUMANBioGRID, IntAct20211142 details
HDAC3_HUMANMK11_HUMANBioGRID, HPRD15356147 details
HDAC3_HUMANZBT16_HUMANBioGRID15467736 24821727 details
HDAC3_HUMANCTBP1_HUMANBioGRID11022042 details
HDAC3_HUMANRUNX2_HUMANBioGRID, HPRD15292260 18321663 details
HDAC3_HUMANGATA1_HUMANBioGRID14668799 details
HDAC3_HUMANNR2C1_HUMANBioGRID, HPRD11463856 12943985 14521922 19204783 21670149 details
HDAC3_HUMANRARA_HUMANBioGRID12943985 details
HDAC3_HUMANRXRA_HUMANBioGRID12943985 details
HDAC3_HUMANNR2C2_HUMANBioGRID12943985 21670149 details
HDAC3_HUMANANDR_HUMANBioGRID12943985 16469706 details
HDAC3_HUMANPPARD_HUMANBioGRID, HPRD11867749 12943985 details
HDAC3_HUMANPPARG_HUMANBioGRID, HPRD12479814 12943985 17015477 24982244 details
HDAC3_HUMANGATA2_HUMANBioGRID, HPRD11567998 details
HDAC3_HUMANTYY1_HUMANBioGRID, HPRD11486036 17925399 18542060 18558095 18940814 19279113 9346952 details
HDAC3_HUMANGTF2I_HUMANBioGRID, HPRD12239342 12393887 16943425 17970752 21549311 details
HDAC3_HUMANRBBP4_HUMANBioGRID, HPRD11470869 11777905 details
HDAC3_HUMANTAB2_HUMANBioGRID, HPRD12150997 details
HDAC3_HUMANHSP7C_HUMANBioGRID, HPRD12502735 details
HDAC3_HUMANPML_HUMANBioGRID, HPRD11259576 details
HDAC3_HUMANDAXX_HUMANBioGRID10669754 details
HDAC3_HUMANVHL_HUMANBioGRID11641274 details
HDAC3_HUMANHIF1A_HUMANBioGRID11641274 17273746 details
HDAC3_HUMANSUV91_HUMANBioGRID, HPRD11788710 details
HDAC3_HUMANHAIR_HUMANBioGRID, HPRD11641275 details
HDAC3_HUMANTHA_HUMANBioGRID11889044 17242407 details
HDAC3_HUMANAKT1_HUMANBioGRID20026773 29523594 details
HDAC3_HUMANEP300_HUMANBioGRID17158926 18542060 19279113 details
HDAC3_HUMANKAT2B_HUMANBioGRID17158926 details
HDAC3_HUMANMEF2D_HUMANBioGRID17158926 details
HDAC3_HUMANATX3_HUMANBioGRID17079677 29802126 details
HDAC3_HUMANRUNX1_HUMANBioGRID16652147 21059642 26598521 details
HDAC3_HUMANCEBPD_HUMANBioGRID17910034 18619497 details
HDAC3_HUMANSRC_HUMANBioGRID16532030 17699109 details
HDAC3_HUMANGCM1_HUMANBioGRID, HPRD16528103 details
HDAC3_HUMANCBP_HUMANBioGRID, HPRD16528103 details
HDAC3_HUMANKSYK_HUMANBioGRID16288017 details
HDAC3_HUMANPARP1_HUMANBioGRID16204234 details
HDAC3_HUMANLCOR_HUMANBioGRID12535528 details
HDAC3_HUMANHNF4A_HUMANBioGRID12205093 details
HDAC3_HUMANLAP2A_HUMANBioGRID16129885 details
HDAC3_HUMANLAP2B_HUMANBioGRID16129885 details
HDAC3_HUMANH4_HUMANBioGRID15832170 24722339 30804502 details
HDAC3_HUMANCSK21_HUMANBioGRID, HPRD15805470 21624135 details
HDAC3_HUMANTHAP7_HUMANBioGRID15561719 details
HDAC3_HUMANSRY_HUMANBioGRID15297880 details
HDAC3_HUMANPHB2_HUMANBioGRID, HPRD15140878 details
HDAC3_HUMANIL16_HUMANBioGRID18097041 details
HDAC3_HUMANCREB3_HUMANBioGRID20473547 details
HDAC3_HUMANTHB_HUMANBioGRID17242407 details
HDAC3_HUMANPRKDC_HUMANBioGRID17242407 details
HDAC3_HUMANBRNP1_HUMANBioGRID21030595 details
HDAC3_HUMANMK14_HUMANBioGRID21444723 details
HDAC3_HUMANCCN5_HUMANBioGRID21262769 details
HDAC3_HUMANNACC1_HUMANBioGRID, HPRD16033423 details
HDAC3_HUMANATF3_HUMANBioGRID22989952 details
HDAC3_HUMANTXNIP_HUMANBioGRID20826751 details
HDAC3_HUMANH31_HUMANBioGRID24722339 details
HDAC3_HUMANH2A1A_HUMANBioGRID24722339 details
HDAC3_HUMANH2B1A_HUMANBioGRID24722339 details
HDAC3_HUMANPIWL2_HUMANBioGRID29555935 details
HDAC3_HUMANFANCJ_HUMANBioGRID22792074 details
HDAC3_HUMANELL_HUMANBioGRID32152128 details
HDAC3_HUMANEED_HUMANHPRD10581039 details
HDAC3_HUMANHDA10_HUMANBioGRID, HPRD, IntAct11861901 details
HDAC3_HUMANTF65_HUMANBioGRID, HPRD, MINT11533489 12419806 15192014 27012186 details
HDAC3_HUMANMBD1_HUMANBioGRID, HPRD, IntAct16432238 details
HDAC3_HUMANCAPAM_HUMANMINT17126328 details
HDAC3_HUMANBC11B_HUMANBioGRID, MINT17245431 details
HDAC3_HUMANHDAC5_HUMANBioGRID, HPRD, IntAct10220385 10869435 11466315 11804585 11931768 21081666 details
HDAC3_HUMANTHA11_HUMANHPRD, IntAct18585351 details
HDAC3_HUMANPROX1_HUMANBioGRID, MINT18948102 details
HDAC3_HUMANZN148_HUMANBioGRID, MINT19583777 details
HDAC3_HUMANBAG1_HUMANMINT19595997 details
HDAC3_HUMANBUB1B_HUMANBioGRID, MINT19407811 28985013 details
HDAC3_HUMANTBL1R_HUMANBioGRID, HPRD, IntAct11931768 16469706 18202150 21258344 23752268 28152507 details
HDAC3_HUMANKDM1A_HUMANBioGRID, IntAct21258344 21670149 23752268 details
HDAC3_HUMANTLE5_HUMANIntAct21251616 details
HDAC3_HUMANPP4R1_HUMANHPRD, MINT15805470 details
HDAC3_HUMANWWOX_HUMANIntAct25678599 details
HDAC3_HUMANEZH2_HUMANBioGRID, IntAct21685935 23079660 details
HDAC3_HUMANSUZ12_HUMANIntAct23079660 details
HDAC3_HUMANMYC_HUMANBioGRID, IntAct, MINT18483244 22002311 23079660 23714368 31155734 details
HDAC3_HUMANCNOT2_HUMANBioGRID, UniProt16712523 details
HDAC3_HUMANRREB1_HUMANBioGRID, IntAct23752268 details
HDAC3_HUMANSMAD7_HUMANBioGRID, IntAct15831498 15831516 19032343 details
HDAC3_HUMANSKI_HUMANBioGRID, IntAct16987993 17621263 19032343 19341714 details
HDAC3_HUMANAKP8L_HUMANUniProt16980585 details
HDAC3_HUMANAKAP8_HUMANUniProt16980585 details
HDAC3_HUMANP53_HUMANDIP, HPRD10777477 16847267 details
HDAC3_HUMANKPYM_HUMANDIP22056988 details
HDAC3_HUMANFMR1_HUMANIntAct31413325 details
HDAC3_HUMANSOX2_HUMANBioGRID, MINT21532573 23667531 details
HDAC3_HUMANKAISO_HUMANBioGRID14527417 details
HDAC3_HUMANJUN_HUMANBioGRID, HPRD12853483 details
HDAC3_HUMANRB_HUMANBioGRID, HPRD10490602 10958676 12479814 details
HDAC3_HUMANGT2D1_HUMANBioGRID, HPRD12239342 16055724 details
HDAC3_HUMANHSP74_HUMANBioGRID, HPRD11777905 details
HDAC3_HUMANXPO1_HUMANBioGRID, HPRD11779848 17141982 26673895 details
HDAC3_HUMANRBL1_HUMANBioGRID10490602 details
HDAC3_HUMANBCOR_HUMANBioGRID, HPRD10898795 details
HDAC3_HUMANMTG16_HUMANBioGRID, HPRD11533236 12242670 details
HDAC3_HUMANIKZF1_HUMANBioGRID12015313 details
HDAC3_HUMANMTG8_HUMANBioGRID, HPRD11533236 15333839 details
HDAC3_HUMANZBT7A_HUMANBioGRID19244234 details
HDAC3_HUMANSMCA4_HUMANBioGRID16469706 19081374 details
HDAC3_HUMANDACH1_HUMANBioGRID17182846 details
HDAC3_HUMANCPSF5_HUMANBioGRID17172643 details
HDAC3_HUMANPAPOA_HUMANBioGRID17172643 details
HDAC3_HUMANSRF_HUMANBioGRID17158926 details
HDAC3_HUMANTTP_HUMANBioGRID19738286 details
HDAC3_HUMANGEMI_HUMANBioGRID16924111 details
HDAC3_HUMANREPI1_HUMANBioGRID16924111 details
HDAC3_HUMANSP30L_HUMANBioGRID16820529 details
HDAC3_HUMANSAP30_HUMANBioGRID16820529 details
HDAC3_HUMANNFAC1_HUMANBioGRID19463978 details
HDAC3_HUMANPRAM_HUMANBioGRID16432238 16730330 details
HDAC3_HUMANRBM15_HUMANBioGRID18667423 details
HDAC3_HUMANINSM1_HUMANBioGRID16569215 details
HDAC3_HUMANIKBA_HUMANBioGRID, HPRD12972430 16371367 details
HDAC3_HUMANNFKB1_HUMANBioGRID12972430 15494311 details
HDAC3_HUMANSP1_HUMANBioGRID16298343 details
HDAC3_HUMANMTG8R_HUMANBioGRID16227606 details
HDAC3_HUMANSAFB1_HUMANBioGRID16195251 21527249 details
HDAC3_HUMANSAFB2_HUMANBioGRID16195251 details
HDAC3_HUMANKDM4A_HUMANBioGRID15927959 details
HDAC3_HUMANKLF6_HUMANBioGRID, HPRD15917248 details
HDAC3_HUMANSTAT3_HUMANBioGRID, HPRD15653507 18037959 22116549 25892518 details
HDAC3_HUMANETV6_HUMANBioGRID11439334 details
HDAC3_HUMANTBX3_HUMANBioGRID18245468 details
HDAC3_HUMANMAFK_HUMANBioGRID18241676 details
HDAC3_HUMANPBX1_HUMANBioGRID11046157 details
HDAC3_HUMANNR2E1_HUMANBioGRID17873065 details
HDAC3_HUMANSPI1_HUMANBioGRID17621263 details
HDAC3_HUMANEMD_HUMANBioGRID17620012 details
HDAC3_HUMANOVOL1_HUMANBioGRID17311813 details
HDAC3_HUMANBCL3_HUMANBioGRID, HPRD15469820 20547759 details
HDAC3_HUMANNOS3_HUMANBioGRID20705923 details
HDAC3_HUMANSIAH2_HUMANBioGRID20691163 details
HDAC3_HUMANPAR14_HUMANBioGRID21081493 details
HDAC3_HUMANIRF3_HUMANBioGRID22027828 details
HDAC3_HUMANP85A_HUMANBioGRID22027828 details
HDAC3_HUMANPRDM4_HUMANBioGRID15051733 details
HDAC3_HUMANNONO_HUMANBioGRID18439917 details
HDAC3_HUMANWDR5_HUMANBioGRID21884981 details
HDAC3_HUMANTWST1_HUMANBioGRID21884981 details
HDAC3_HUMANANRA2_HUMANBioGRID22649097 details
HDAC3_HUMANE2F4_HUMANBioGRID22508987 details
HDAC3_HUMANNRDC_HUMANBioGRID22294699 details
HDAC3_HUMANDNMT1_HUMANBioGRID21670149 details
HDAC3_HUMANKDM4C_HUMANBioGRID21637537 details
HDAC3_HUMAN1433T_HUMANBioGRID21624135 details
HDAC3_HUMANDDX5_HUMANBioGRID19995069 20663877 details
HDAC3_HUMANDDX17_HUMANBioGRID19995069 20663877 details
HDAC3_HUMANZBT7B_HUMANBioGRID22730529 details
HDAC3_HUMANSTAT1_HUMANBioGRID16481475 details
HDAC3_HUMANTIF1B_HUMANBioGRID18037959 details
HDAC3_HUMANPRDM6_HUMANBioGRID16537907 details
HDAC3_HUMANNF2L2_HUMANBioGRID22308472 details
HDAC3_HUMANMEF2A_HUMANBioGRID22308472 details
HDAC3_HUMANAPEX1_HUMANBioGRID14633989 details
HDAC3_HUMANSRBP2_HUMANBioGRID18403372 details
HDAC3_HUMANKAT5_HUMANBioGRID25301942 details
HDAC3_HUMANPP1A_HUMANBioGRID16186112 details
HDAC3_HUMANDCAF1_HUMANBioGRID26679995 details
HDAC3_HUMANDDB1_HUMANBioGRID26679995 details
HDAC3_HUMANMAGB2_HUMANBioGRID26468294 details
HDAC3_HUMANBCL6_HUMANBioGRID26728228 details
HDAC3_HUMANUBP44_HUMANBioGRID27880911 32076268 details
HDAC3_HUMANFOXK2_HUMANBioGRID27773593 details
HDAC3_HUMANCSK22_HUMANBioGRID29555935 details
HDAC3_HUMANIGF1R_HUMANBioGRID29523594 details
HDAC3_HUMANTRAF6_HUMANBioGRID31155734 details
HDAC3_HUMANMDM2_HUMANBioGRID31358320 details
HDAC3_HUMANSPT5H_HUMANBioGRID29395067 details
HDAC3_HUMANCCAR2_HUMANBioGRID32152128 details
HDAC3_HUMANMPIP1_HUMANBioGRID27462461 details
HDAC3_HUMANARI4A_HUMANHPRD10490602 details
HDAC3_HUMANHDAC1_HUMANHPRD10944117 11302704 details
HDAC3_HUMANCOR2A_HUMANHPRD12628926 details
HDAC3_HUMANTNR14_HUMANHPRD11463856 details
HDAC3_HUMANSMYD1_HUMANHPRD11923873 details
HDAC3_HUMANPIAS2_HUMANHPRD12239342 details
HDAC3_HUMANDHX30_HUMANHPRD17255935 details
HDAC3_HUMANNR2E3_HUMANHPRD17255935 details