Entity Details

Primary name TRXR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NNW7
EntryNameTRXR2_HUMAN
FullNameThioredoxin reductase 2, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length524
SequenceStatuscomplete
DateCreated2003-09-19
DateModified2021-06-02

Ontological Relatives

GenesTXNRD2

GO terms

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GOName
GO:0000305 response to oxygen radical
GO:0004791 thioredoxin-disulfide reductase activity
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0034599 cellular response to oxidative stress
GO:0043231 intracellular membrane-bounded organelle
GO:0045454 cell redox homeostasis
GO:0050660 flavin adenine dinucleotide binding

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR001100 Pyridine nucleotide-disulphide oxidoreductase, class IFamilyFamily
IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domainDomainDomain
IPR006338 Thioredoxin/glutathione reductase selenoproteinFamilyFamily
IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active siteSiteActive site
IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamilyFamilyHomologous superfamily
IPR023753 FAD/NAD(P)-binding domainDomainDomain
IPR036188 FAD/NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05428 Motexafin gadoliniumDrugbanksmall molecule