Entity Details

Primary name SIR7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NRC8
EntryNameSIR7_HUMAN
FullNameNAD-dependent protein deacetylase sirtuin-7
TaxID9606
Evidenceevidence at protein level
Length400
SequenceStatuscomplete
DateCreated2003-10-31
DateModified2021-06-02

Ontological Relatives

GenesSIRT7

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0001649 osteoblast differentiation
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005731 nucleolus organizer region
GO:0005737 cytoplasm
GO:0006111 regulation of gluconeogenesis
GO:0006281 DNA repair
GO:0006282 regulation of DNA repair
GO:0006476 protein deacetylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007072 positive regulation of transcription involved in exit from mitosis
GO:0007129 homologous chromosome pairing at meiosis
GO:0009303 rRNA transcription
GO:0010529 negative regulation of transposition
GO:0010821 regulation of mitochondrion organization
GO:0016570 histone modification
GO:0016607 nuclear speck
GO:0019213 deacetylase activity
GO:0031397 negative regulation of protein ubiquitination
GO:0034979 NAD-dependent protein deacetylase activity
GO:0035861 site of double-strand break
GO:0036049 peptidyl-lysine desuccinylation
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046825 regulation of protein export from nucleus
GO:0046872 metal ion binding
GO:0061697 protein-glutaryllysine deglutarylase activity
GO:0061698 protein deglutarylation
GO:0062176 R-loop disassembly
GO:0070403 NAD+ binding
GO:0070932 histone H3 deacetylation
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
GO:0106230 protein depropionylation
GO:0106231 protein-propionyllysine depropionylase activity
GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO:1990258 histone glutamine methylation
GO:2000234 positive regulation of rRNA processing
GO:2001032 regulation of double-strand break repair via nonhomologous end joining

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003000 Sirtuin familyFamilyFamily
IPR026590 Sirtuin family, catalytic core domainDomainDomain
IPR029035 DHS-like NAD/FAD-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
SIR7_HUMANMAGD1_HUMANBioGRID, HPRD, IntAct16169070 details
SIR7_HUMANUBF1_HUMANBioGRID19174463 22147730 22586326 24207024 26867678 details
SIR7_HUMANH4_HUMANBioGRID16618798 30804502 details
SIR7_HUMANU3IP2_HUMANBioGRID22586326 26867678 details
SIR7_HUMANDDB1_HUMANBioGRID22586326 24703702 28655758 28886238 details
SIR7_HUMANA4_HUMANBioGRID21832049 details
SIR7_HUMANMEP50_HUMANBioGRID28886238 30282801 32711345 details
SIR7_HUMANH2A2C_HUMANBioGRID16618798 details
SIR7_HUMANFBRL_HUMANBioGRID22586326 30540930 32711345 details
SIR7_HUMANKAT2B_HUMANBioGRID32404984 details
SIR7_HUMANSNUT2_HUMANBioGRID32711345 details
SIR7_HUMANUBP7_HUMANBioGRID22586326 28655758 32711345 details
SIR7_HUMANH2B2E_HUMANBioGRID16618798 details
SIR7_HUMANH31_HUMANBioGRID16618798 details
SIR7_HUMANRPA49_HUMANBioGRID24207024 details
SIR7_HUMANCUL4A_HUMANBioGRID28886238 details
SIR7_HUMANCUL4B_HUMANBioGRID22586326 28886238 details
SIR7_HUMANUB2R2_HUMANBioGRID28886238 details
SIR7_HUMANMBB1A_HUMANBioGRID22147730 22586326 28655758 details
SIR7_HUMANRPA1_HUMANBioGRID16618798 22147730 22586326 24207024 details
SIR7_HUMANRBBP7_HUMANBioGRID22586326 28886238 details
SIR7_HUMANNR0B2_HUMANBioGRID20375098 details
SIR7_HUMANCDK9_HUMANBioGRID28655758 details
SIR7_HUMANDCAF7_HUMANBioGRID28886238 details
SIR7_HUMANHERC5_HUMANBioGRID22586326 28655758 details
SIR7_HUMANXRCC6_HUMANBioGRID22586326 28655758 details
SIR7_HUMANMDM2_HUMANBioGRID28196907 details
SIR7_HUMANNRF1_HUMANDIP25792330 details
SIR7_HUMANNOP58_HUMANBioGRID22586326 26867678 30540930 details
SIR7_HUMANDCA11_HUMANBioGRID28886238 details
SIR7_HUMANCSN5_HUMANBioGRID28886238 details
SIR7_HUMANELK4_HUMANBioGRID, DIP22722849 28655758 details
SIR7_HUMANPSME2_HUMANBioGRID28655758 details
SIR7_HUMANFOXO1_HUMANBioGRID28655758 details
SIR7_HUMANDCAF1_HUMANBioGRID24703702 details
SIR7_HUMANNUCL_HUMANBioGRID22586326 26867678 details
SIR7_HUMANSIR1_HUMANBioGRID28655758 details
SIR7_HUMANDCAF5_HUMANBioGRID28886238 details
SIR7_HUMANCSN4_HUMANBioGRID28886238 details