Entity Details

Primary name SMC4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NTJ3
EntryNameSMC4_HUMAN
FullNameStructural maintenance of chromosomes protein 4
TaxID9606
Evidenceevidence at protein level
Length1288
SequenceStatuscomplete
DateCreated2003-04-23
DateModified2021-06-02

Ontological Relatives

GenesSMC4

GO terms

Show/Hide Table
GOName
GO:0000070 mitotic sister chromatid segregation
GO:0000775 chromosome, centromeric region
GO:0000796 condensin complex
GO:0003682 chromatin binding
GO:0003697 single-stranded DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0007076 mitotic chromosome condensation
GO:0010032 meiotic chromosome condensation
GO:0016607 nuclear speck
GO:0016887 ATP hydrolysis activity
GO:0045132 meiotic chromosome segregation
GO:0051301 cell division
GO:0051383 kinetochore organization

Subcellular Location

Show/Hide Table
Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR003395 RecF/RecN/SMC, N-terminalDomainDomain
IPR010935 SMCs flexible hingeDomainDomain
IPR024704 Structural maintenance of chromosomes proteinFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036277 SMCs flexible hinge superfamilyFamilyHomologous superfamily
IPR041738 Structural maintenance of chromosomes 4, ABC domain, eukaryoticDomainDomain

Diseases

Show/Hide Table

Interactions

24 interactions

InteractorPartnerSourcesPublicationsLink
SMC4_HUMANMIPT3_HUMANBioGRID, IntAct17043677 31413325 details
SMC4_HUMANPTEN_HUMANBioGRID31685992 details
SMC4_HUMANSUMO2_HUMANBioGRID32786267 details
SMC4_HUMANNEMO_HUMANIntAct14743216 details
SMC4_HUMANSMYD2_HUMANIntAct17353931 details
SMC4_HUMANMYC_HUMANBioGRID, IntAct17314511 17353931 21150319 29467282 details
SMC4_HUMANCASP4_HUMANIntAct17353931 details
SMC4_HUMANCRCM_HUMANIntAct17353931 details
SMC4_HUMANPHLA3_HUMANIntAct17353931 details
SMC4_HUMANIKKE_HUMANIntAct17353931 details
SMC4_HUMANSMC2_HUMANBioGRID, HPRD, IntAct, MINT14532007 17113138 17268547 22863883 22939629 26166704 26344197 30021884 9789013 details
SMC4_HUMANCND2_HUMANBioGRID, IntAct, MINT17268547 22863883 22939629 24981860 26166704 26344197 26496610 details
SMC4_HUMANCNDH2_HUMANBioGRID, IntAct, MINT14532007 17268547 26166704 28514442 details
SMC4_HUMANCNDD3_HUMANBioGRID, IntAct14532007 26496610 details
SMC4_HUMANINTU_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC4_HUMANESR1_HUMANBioGRID, IntAct26166704 31527615 details
SMC4_HUMANCND3_HUMANBioGRID, MINT11136719 14532007 22863883 22939629 24981860 26166704 26344197 details
SMC4_HUMANDNM3B_HUMANBioGRID15148359 details
SMC4_HUMANCND1_HUMANBioGRID, HPRD10958694 22863883 22939629 26344197 details
SMC4_HUMANHDAC1_HUMANBioGRID20585571 details
SMC4_HUMANTOPB1_HUMANBioGRID24239288 details
SMC4_HUMANSIR6_HUMANBioGRID24169447 details
SMC4_HUMANABCE1_HUMANBioGRID25659154 details
SMC4_HUMANTRI29_HUMANBioGRID26095369 details