Entity Details

Primary name SIR5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NXA8
EntryNameSIR5_HUMAN
FullNameNAD-dependent protein deacylase sirtuin-5, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length310
SequenceStatuscomplete
DateCreated2003-10-31
DateModified2021-06-02

Ontological Relatives

GenesSIRT5

GO terms

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GOName
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006471 protein ADP-ribosylation
GO:0006476 protein deacetylation
GO:0007005 mitochondrion organization
GO:0008270 zinc ion binding
GO:0010566 regulation of ketone biosynthetic process
GO:0036046 protein demalonylation
GO:0036047 peptidyl-lysine demalonylation
GO:0036048 protein desuccinylation
GO:0036049 peptidyl-lysine desuccinylation
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0061697 protein-glutaryllysine deglutarylase activity
GO:0061698 protein deglutarylation
GO:0070403 NAD+ binding
GO:2000378 negative regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Mitochondrion intermembrane space
Mitochondrion matrix
Nucleus

Domains

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DomainNameCategoryType
IPR003000 Sirtuin familyFamilyFamily
IPR026590 Sirtuin family, catalytic core domainDomainDomain
IPR026591 Sirtuin, catalytic core small domain superfamilyFamilyHomologous superfamily
IPR027546 Sirtuin, class IIIFamilyFamily
IPR029035 DHS-like NAD/FAD-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02059 Adenosine-5-DiphosphoriboseDrugbanksmall molecule
DB02701 NicotinamideDrugbanksmall molecule
DB03478 2'-O-Acetyl Adenosine-5-DiphosphoriboseDrugbanksmall molecule
DB04786 SuraminDrugbanksmall molecule
DB15493 CambinolDrugbanksmall molecule