Entity Details

Primary name TREM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NZC2
EntryNameTREM2_HUMAN
FullNameTriggering receptor expressed on myeloid cells 2
TaxID9606
Evidenceevidence at protein level
Length230
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesTREM2

GO terms

Show/Hide Table
GOName
GO:0001530 lipopolysaccharide binding
GO:0001540 amyloid-beta binding
GO:0001774 microglial cell activation
GO:0001934 positive regulation of protein phosphorylation
GO:0002282 microglial cell activation involved in immune response
GO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0002931 response to ischemia
GO:0004888 transmembrane signaling receptor activity
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006911 phagocytosis, engulfment
GO:0006959 humoral immune response
GO:0008035 high-density lipoprotein particle binding
GO:0008289 lipid binding
GO:0010468 regulation of gene expression
GO:0010507 negative regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010822 positive regulation of mitochondrion organization
GO:0016021 integral component of membrane
GO:0030169 low-density lipoprotein particle binding
GO:0030316 osteoclast differentiation
GO:0031226 intrinsic component of plasma membrane
GO:0032006 regulation of TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032497 detection of lipopolysaccharide
GO:0032499 detection of peptidoglycan
GO:0032675 regulation of interleukin-6 production
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032733 positive regulation of interleukin-10 production
GO:0034185 apolipoprotein binding
GO:0034186 apolipoprotein A-I binding
GO:0034189 very-low-density lipoprotein particle binding
GO:0034241 positive regulation of macrophage fusion
GO:0038023 signaling receptor activity
GO:0042742 defense response to bacterium
GO:0042834 peptidoglycan binding
GO:0043066 negative regulation of apoptotic process
GO:0043277 apoptotic cell clearance
GO:0044853 plasma membrane raft
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045088 regulation of innate immune response
GO:0045672 positive regulation of osteoclast differentiation
GO:0048143 astrocyte activation
GO:0050714 positive regulation of protein secretion
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050921 positive regulation of chemotaxis
GO:0060075 regulation of resting membrane potential
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0061518 microglial cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070392 detection of lipoteichoic acid
GO:0070891 lipoteichoic acid binding
GO:0071223 cellular response to lipoteichoic acid
GO:0071224 cellular response to peptidoglycan
GO:0071640 regulation of macrophage inflammatory protein 1 alpha production
GO:0071813 lipoprotein particle binding
GO:0097028 dendritic cell differentiation
GO:0097110 scaffold protein binding
GO:0097242 amyloid-beta clearance
GO:0098657 import into cell
GO:0120035 regulation of plasma membrane bounded cell projection organization
GO:0150062 complement-mediated synapse pruning
GO:0150076 neuroinflammatory response
GO:1900223 positive regulation of amyloid-beta clearance
GO:1901076 positive regulation of engulfment of apoptotic cell
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1901980 positive regulation of inward rectifier potassium channel activity
GO:1902531 regulation of intracellular signal transduction
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903082 positive regulation of C-C chemokine receptor CCR7 signaling pathway
GO:1903980 positive regulation of microglial cell activation
GO:1904093 negative regulation of autophagic cell death
GO:1904141 positive regulation of microglial cell migration
GO:1904646 cellular response to amyloid-beta
GO:1905291 positive regulation of CAMKK-AMPK signaling cascade
GO:1990782 protein tyrosine kinase binding
GO:2000350 positive regulation of CD40 signaling pathway
GO:2001171 positive regulation of ATP biosynthetic process

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table