Entity Details

Primary name FZD4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9ULV1
EntryNameFZD4_HUMAN
FullNameFrizzled-4
TaxID9606
Evidenceevidence at protein level
Length537
SequenceStatuscomplete
DateCreated2001-12-05
DateModified2021-06-02

Ontological Relatives

GenesFZD4

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001570 vasculogenesis
GO:0004896 cytokine receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007605 sensory perception of sound
GO:0009986 cell surface
GO:0010812 negative regulation of cell-substrate adhesion
GO:0016055 Wnt signaling pathway
GO:0017147 Wnt-protein binding
GO:0019955 cytokine binding
GO:0030165 PDZ domain binding
GO:0030182 neuron differentiation
GO:0030425 dendrite
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031625 ubiquitin protein ligase binding
GO:0031987 locomotion involved in locomotory behavior
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035426 extracellular matrix-cell signaling
GO:0035567 non-canonical Wnt signaling pathway
GO:0038023 signaling receptor activity
GO:0042701 progesterone secretion
GO:0042803 protein homodimerization activity
GO:0042813 Wnt-activated receptor activity
GO:0043507 positive regulation of JUN kinase activity
GO:0044877 protein-containing complex binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046982 protein heterodimerization activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061024 membrane organization
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:0061301 cerebellum vasculature morphogenesis
GO:0061304 retinal blood vessel morphogenesis
GO:0071300 cellular response to retinoic acid
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0098978 glutamatergic synapse
GO:0110135 Norrin signaling pathway
GO:0150012 positive regulation of neuron projection arborization
GO:1990830 cellular response to leukemia inhibitory factor

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000539 Frizzled/Smoothened, transmembrane domainDomainDomain
IPR015526 Frizzled/secreted frizzled-related proteinFamilyFamily
IPR017981 GPCR, family 2-likeDomainDomain
IPR020067 Frizzled domainDomainDomain
IPR026551 Frizzled-4FamilyFamily
IPR036790 Frizzled cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR041765 Frizzled 4, cysteine-rich domainDomainDomain

Diseases

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