Entity Details

Primary name ABCG2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UNQ0
EntryNameABCG2_HUMAN
FullNameBroad substrate specificity ATP-binding cassette transporter ABCG2
TaxID9606
Evidenceevidence at protein level
Length655
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesABCG2

GO terms

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GOName
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0006783 heme biosynthetic process
GO:0006879 cellular iron ion homeostasis
GO:0008514 organic anion transmembrane transporter activity
GO:0008559 ABC-type xenobiotic transporter activity
GO:0015143 urate transmembrane transporter activity
GO:0015225 biotin transmembrane transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0015711 organic anion transport
GO:0015878 biotin transport
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0031966 mitochondrial membrane
GO:0032217 riboflavin transmembrane transporter activity
GO:0032218 riboflavin transport
GO:0042167 heme catabolic process
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042910 xenobiotic transmembrane transporter activity
GO:0045121 membrane raft
GO:0046415 urate metabolic process
GO:0055085 transmembrane transport
GO:0070633 transepithelial transport
GO:0097744 urate salt excretion
GO:0098591 external side of apical plasma membrane
GO:0140115 export across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1990748 cellular detoxification
GO:1990962 xenobiotic transport across blood-brain barrier

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Mitochondrion membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR013525 ABC-2 type transporterDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030256 ATP-binding cassette subfamily G member 2FamilyFamily
IPR043926 ABC transporter family G domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00091 CyclosporineDrugbanksmall molecule
DB00158 Folic acidDrugbanksmall molecule
DB00175 PravastatinDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB00213 PantoprazoleDrugbanksmall molecule
DB00220 NelfinavirDrugbanksmall molecule
DB00242 CladribineDrugbanksmall molecule
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00285 VenlafaxineDrugbanksmall molecule
DB00286 Conjugated estrogensDrugbanksmall molecule
DB00317 GefitinibDrugbanksmall molecule
DB00338 OmeprazoleDrugbanksmall molecule
DB00394 Beclomethasone dipropionateDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00398 SorafenibDrugbanksmall molecule
DB00437 AllopurinolDrugbanksmall molecule
DB00439 CerivastatinDrugbanksmall molecule
DB00444 TeniposideDrugbanksmall molecule
DB00448 LansoprazoleDrugbanksmall molecule
DB00457 PrazosinDrugbanksmall molecule
DB00470 DronabinolDrugbanksmall molecule
DB00481 RaloxifeneDrugbanksmall molecule
DB00482 CelecoxibDrugbanksmall molecule
DB00495 ZidovudineDrugbanksmall molecule
DB00503 RitonavirDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00526 OxaliplatinSwissprotsmall molecule
DB00530 ErlotinibDrugbanksmall molecule
DB00541 VincristineDrugbanksmall molecule
DB00544 FluorouracilDrugbanksmall molecule
DB00549 ZafirlukastDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB00602 IvermectinDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB00624 TestosteroneDrugbanksmall molecule
DB00631 ClofarabineDrugbanksmall molecule
DB00655 EstroneDrugbanksmall molecule
DB00669 SumatriptanDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00688 Mycophenolate mofetilDrugbanksmall molecule
DB00694 DaunorubicinDrugbanksmall molecule
DB00698 NitrofurantoinDrugbanksmall molecule
DB00709 LamivudineDrugbanksmall molecule
DB00740 RiluzoleDrugbanksmall molecule
DB00762 IrinotecanDrugbanksmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00795 SulfasalazineDrugbanksmall molecule
DB00843 DonepezilDrugbanksmall molecule
DB00845 ClofazimineDrugbanksmall molecule
DB00921 BuprenorphineDrugbanksmall molecule
DB00958 CarboplatinSwissprotsmall molecule
DB00966 TelmisartanDrugbanksmall molecule
DB00970 DactinomycinDrugbanksmall molecule
DB00973 EzetimibeDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01016 GlyburideDrugbanksmall molecule
DB01030 TopotecanDrugbanksmall molecule
DB01051 NovobiocinDrugbanksmall molecule
DB01079 TegaserodDrugbanksmall molecule
DB01094 HesperetinDrugbanksmall molecule
DB01097 LeflunomideDrugbanksmall molecule
DB01098 RosuvastatinDrugbanksmall molecule
DB01129 RabeprazoleDrugbanksmall molecule
DB01204 MitoxantroneDrugbanksmall molecule
DB01232 SaquinavirDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB01248 DocetaxelDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB01268 SunitinibDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB01685 TopiroxostatDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB02115 DaidzinDrugbanksmall molecule
DB02703 Fusidic acidDrugbanksmall molecule
DB03467 NaringeninDrugbanksmall molecule
DB03496 AlvocidibDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04348 Taurocholic acidDrugbanksmall molecule
DB04540 CholesterolDrugbanksmall molecule
DB04690 CamptothecinDrugbanksmall molecule
DB04851 BiricodarDrugbanksmall molecule
DB04868 NilotinibDrugbanksmall molecule
DB04881 ElacridarDrugbanksmall molecule
DB05239 CobimetinibDrugbanksmall molecule
DB05294 VandetanibDrugbanksmall molecule
DB05928 DovitinibDrugbanksmall molecule
DB06210 EltrombopagDrugbanksmall molecule
DB06228 RivaroxabanDrugbanksmall molecule
DB06290 SimeprevirDrugbanksmall molecule
DB06448 LonafarnibDrugbanksmall molecule
DB06589 PazopanibDrugbanksmall molecule
DB06605 ApixabanDrugbanksmall molecule
DB06654 SafinamideDrugbanksmall molecule
DB06772 CabazitaxelDrugbanksmall molecule
DB06813 PralatrexateDrugbanksmall molecule
DB08828 VismodegibDrugbanksmall molecule
DB08860 PitavastatinDrugbanksmall molecule
DB08864 RilpivirineDrugbanksmall molecule
DB08880 TeriflunomideDrugbanksmall molecule
DB08881 VemurafenibDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB08907 CanagliflozinDrugbanksmall molecule
DB08912 DabrafenibDrugbanksmall molecule
DB08916 AfatinibDrugbanksmall molecule
DB08930 DolutegravirDrugbanksmall molecule
DB08931 RiociguatDrugbanksmall molecule
DB08934 SofosbuvirDrugbanksmall molecule
DB09027 LedipasvirDrugbanksmall molecule
DB09038 EmpagliflozinDrugbanksmall molecule
DB09054 IdelalisibDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09065 CobicistatSwissprotsmall molecule
DB09073 PalbociclibDrugbanksmall molecule
DB09074 OlaparibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB09102 DaclatasvirDrugbanksmall molecule
DB09183 DasabuvirDrugbanksmall molecule
DB09274 ArtesunateDrugbanksmall molecule
DB09279 FimasartanDrugbanksmall molecule
DB09291 RolapitantDrugbanksmall molecule
DB09296 OmbitasvirDrugbanksmall molecule
DB09297 ParitaprevirDrugbanksmall molecule
DB09299 Tenofovir alafenamideDrugbanksmall molecule
DB09330 OsimertinibDrugbanksmall molecule
DB11363 AlectinibDrugbanksmall molecule
DB11581 VenetoclaxDrugbanksmall molecule
DB11613 VelpatasvirDrugbanksmall molecule
DB11633 IsavuconazoleDrugbanksmall molecule
DB11644 TafamidisDrugbanksmall molecule
DB11652 TucatinibDrugbanksmall molecule
DB11689 SelumetinibDrugbanksmall molecule
DB11712 TezacaftorDrugbanksmall molecule
DB11732 LasmiditanDrugbanksmall molecule
DB11757 IstradefyllineDrugbanksmall molecule
DB11760 TalazoparibDrugbanksmall molecule
DB11791 CapmatinibDrugbanksmall molecule
DB11796 FostemsavirDrugbanksmall molecule
DB11817 BaricitinibDrugbanksmall molecule
DB11820 NifurtimoxDrugbanksmall molecule
DB11827 ErtugliflozinDrugbanksmall molecule
DB11853 RelugolixDrugbanksmall molecule
DB11855 RevefenacinDrugbanksmall molecule
DB11901 ApalutamideDrugbanksmall molecule
DB11943 DelafloxacinDrugbanksmall molecule
DB11952 DuvelisibDrugbanksmall molecule
DB11963 DacomitinibDrugbanksmall molecule
DB11978 GlasdegibDrugbanksmall molecule
DB11995 AvatrombopagDrugbanksmall molecule
DB12001 AbemaciclibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12015 AlpelisibDrugbanksmall molecule
DB12026 VoxilaprevirDrugbanksmall molecule
DB12070 LetermovirDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB12332 RucaparibDrugbanksmall molecule
DB12457 RimegepantDrugbanksmall molecule
DB12483 CopanlisibDrugbanksmall molecule
DB12500 FedratinibDrugbanksmall molecule
DB12612 OzanimodDrugbanksmall molecule
DB12887 TazemetostatDrugbanksmall molecule
DB12941 DarolutamideDrugbanksmall molecule
DB13125 LusutrombopagDrugbanksmall molecule
DB13874 EnasidenibDrugbanksmall molecule
DB13878 PibrentasvirDrugbanksmall molecule
DB13879 GlecaprevirDrugbanksmall molecule
DB13943 Testosterone cypionateDrugbanksmall molecule
DB13944 Testosterone enanthateDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14538 Hydrocortisone aceponateDrugbanksmall molecule
DB14539 Hydrocortisone acetateDrugbanksmall molecule
DB14540 Hydrocortisone butyrateDrugbanksmall molecule
DB14541 Hydrocortisone cypionateDrugbanksmall molecule
DB14542 Hydrocortisone phosphateDrugbanksmall molecule
DB14543 Hydrocortisone probutateDrugbanksmall molecule
DB14544 Hydrocortisone valerateDrugbanksmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule
DB14723 LarotrectinibDrugbanksmall molecule
DB14840 RipretinibDrugbanksmall molecule
DB14962 Trastuzumab deruxtecanDrugbankbiotech
DB15091 UpadacitinibDrugbanksmall molecule
DB15102 PemigatinibDrugbanksmall molecule
DB15233 AvapritinibDrugbanksmall molecule
DB15305 RisdiplamSwissprotsmall molecule
DB15328 UbrogepantDrugbanksmall molecule
DB15685 SelpercatinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule
DB15982 BerotralstatDrugbanksmall molecule

Interactions

3 interactions