Entity Details

Primary name NAC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UPR5
EntryNameNAC2_HUMAN
FullNameSodium/calcium exchanger 2
TaxID9606
Evidenceevidence at transcript level
Length921
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesSLC8A2

GO terms

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GOName
GO:0002931 response to ischemia
GO:0005432 calcium:sodium antiporter activity
GO:0005516 calmodulin binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006811 ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0007154 cell communication
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0010468 regulation of gene expression
GO:0014069 postsynaptic density
GO:0015081 sodium ion transmembrane transporter activity
GO:0015085 calcium ion transmembrane transporter activity
GO:0015491 cation:cation antiporter activity
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030001 metal ion transport
GO:0030424 axon
GO:0030425 dendrite
GO:0035725 sodium ion transmembrane transport
GO:0042383 sarcolemma
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0043679 axon terminus
GO:0045202 synapse
GO:0046872 metal ion binding
GO:0048172 regulation of short-term neuronal synaptic plasticity
GO:0050808 synapse organization
GO:0050890 cognition
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0060291 long-term synaptic potentiation
GO:0070050 neuron cellular homeostasis
GO:0070588 calcium ion transmembrane transport
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0098703 calcium ion import across plasma membrane
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0098815 modulation of excitatory postsynaptic potential
GO:0099608 regulation of action potential firing pattern
GO:0106056 regulation of calcineurin-mediated signaling
GO:0150104 transport across blood-brain barrier
GO:1903779 regulation of cardiac conduction
GO:1905060 calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1990034 calcium ion export across plasma membrane

Subcellular Location

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Subcellular Location
Basolateral cell membrane
Cell membrane
Cell projection
Perikaryon

Domains

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DomainNameCategoryType
IPR003644 Na-Ca exchanger/integrin-beta4DomainDomain
IPR004836 Sodium/calcium exchanger proteinFamilyFamily
IPR004837 Sodium/calcium exchanger membrane regionDomainDomain
IPR032452 Sodium/calcium exchanger domain, C-terminal extensionDomainDomain
IPR038081 CalX-like domain superfamilyFamilyHomologous superfamily

Diseases

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