Entity Details

Primary name KALRN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60229
EntryNameKALRN_HUMAN
FullNameKalirin
TaxID9606
Evidenceevidence at protein level
Length2986
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesKALRN

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0007528 neuromuscular junction development
GO:0007595 lactation
GO:0007613 memory
GO:0008344 adult locomotory behavior
GO:0015629 actin cytoskeleton
GO:0016192 vesicle-mediated transport
GO:0035176 social behavior
GO:0035556 intracellular signal transduction
GO:0042711 maternal behavior
GO:0043065 positive regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0046872 metal ion binding
GO:0046959 habituation
GO:0048013 ephrin receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0060125 negative regulation of growth hormone secretion
GO:0060137 maternal process involved in parturition
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0070062 extracellular exosome
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001251 CRAL-TRIO lipid binding domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR028570 Rho GDP/GTP exchange factor Kalirin/TRIOFamilyFamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036865 CRAL-TRIO lipid binding domain superfamilyFamilyHomologous superfamily

Diseases

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