Entity Details

Primary name SODC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00441
EntryNameSODC_HUMAN
FullNameSuperoxide dismutase [Cu-Zn]
TaxID9606
Evidenceevidence at protein level
Length154
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesSOD1

GO terms

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GOName
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005764 lysosome
GO:0006879 cellular iron ion homeostasis
GO:0007283 spermatogenesis
GO:0007569 cell aging
GO:0007605 sensory perception of sound
GO:0010033 response to organic substance
GO:0030346 protein phosphatase 2B binding
GO:0031267 small GTPase binding
GO:0032930 positive regulation of superoxide anion generation
GO:0040014 regulation of multicellular organism growth
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0045859 regulation of protein kinase activity
GO:0046688 response to copper ion
GO:0046716 muscle cell cellular homeostasis
GO:0048538 thymus development
GO:0048678 response to axon injury
GO:0050665 hydrogen peroxide biosynthetic process
GO:0060047 heart contraction
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0000303 response to superoxide
GO:0001541 ovarian follicle development
GO:0001819 positive regulation of cytokine production
GO:0001890 placenta development
GO:0001895 retina homeostasis
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0007566 embryo implantation
GO:0008089 anterograde axonal transport
GO:0008090 retrograde axonal transport
GO:0019226 transmission of nerve impulse
GO:0031045 dense core granule
GO:0032287 peripheral nervous system myelin maintenance
GO:0032991 protein-containing complex
GO:0035722 interleukin-12-mediated signaling pathway
GO:0042493 response to drug
GO:0042554 superoxide anion generation
GO:0042802 identical protein binding
GO:1904115 axon cytoplasm
GO:0000187 obsolete activation of MAPK activity
GO:0002262 myeloid cell homeostasis
GO:0002576 platelet degranulation
GO:0004784 superoxide dismutase activity
GO:0005507 copper ion binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006749 glutathione metabolic process
GO:0007626 locomotory behavior
GO:0008217 regulation of blood pressure
GO:0019430 removal of superoxide radicals
GO:0031410 cytoplasmic vesicle
GO:0031667 response to nutrient levels
GO:0033081 regulation of T cell differentiation in thymus
GO:0034465 response to carbon monoxide
GO:0045471 response to ethanol
GO:0050728 negative regulation of inflammatory response
GO:0071276 cellular response to cadmium ion
GO:0097332 response to antipsychotic drug
GO:0001975 response to amphetamine
GO:0005615 extracellular space
GO:0005759 mitochondrial matrix
GO:0006801 superoxide metabolic process
GO:0008270 zinc ion binding
GO:0009408 response to heat
GO:0032839 dendrite cytoplasm
GO:0034599 cellular response to oxidative stress
GO:0035865 cellular response to potassium ion
GO:0042542 response to hydrogen peroxide
GO:0043087 regulation of GTPase activity
GO:0045541 negative regulation of cholesterol biosynthetic process
GO:0046620 regulation of organ growth
GO:0046677 response to antibiotic
GO:0050766 positive regulation of phagocytosis
GO:0051087 chaperone binding
GO:0051881 regulation of mitochondrial membrane potential
GO:0060052 neurofilament cytoskeleton organization
GO:0060087 relaxation of vascular associated smooth muscle
GO:0060088 auditory receptor cell stereocilium organization
GO:0070062 extracellular exosome
GO:0071318 cellular response to ATP
GO:0072593 reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR001424 Superoxide dismutase, copper/zinc binding domainDomainDomain
IPR018152 Superoxide dismutase, copper/zinc, binding siteSiteBinding site
IPR024134 Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperoneFamilyFamily
IPR036423 Superoxide dismutase-like, copper/zinc binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618598 OMIMSpastic tetraplegia and axial hypotonia, progressive (STAHP)An autosomal recessive, neurologic disorder characterized by loss of motor abilities in the first year of life, after which severe, progressive spastic tetraparesis develops. Affected individuals have severe axial hypotonia, hyperekplexia, hypertonia, and myokymia, reflecting upper motor neuron involvement. Cognitive development may be affected. The disease is caused by variants affecting the gene represented in this entry.
105400 OMIMAmyotrophic lateral sclerosis 1 (ALS1)A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00163 Vitamin EDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00526 OxaliplatinSwissprotsmall molecule
DB00958 CarboplatinSwissprotsmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01064 IsoprenalineDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB01629 5-fluorouridineDrugbanksmall molecule
DB03382 S-oxy-L-cysteineDrugbanksmall molecule
DB05025 ArimoclomolDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB09221 PolaprezincDrugbanksmall molecule
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule
DB14002 D-alpha-Tocopherol acetateDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

100 interactions

InteractorPartnerSourcesPublicationsLink
SODC_HUMANRAC1_HUMANUniProt18219391 details
SODC_HUMANSMAD2_HUMANBioGRID, IntAct20195357 details
SODC_HUMANSODC_HUMANBioGRID, DIP, HPRD, MINT12754496 1463506 17592131 19022905 19171884 19369197 19828437 21257910 22993064 23831581 24691167 30735496 31999698 details
SODC_HUMANPARK7_HUMANBioGRID, IntAct20406884 24947010 24981860 29128334 31536960 details
SODC_HUMANCCS_HUMANBioGRID, HPRD, IntAct, MINT10677207 12968035 20154138 22508683 24981860 26344197 26496610 28514442 30735496 9726962 details
SODC_HUMANPRS4_HUMANBioGRID, IntAct29128334 32814053 details
SODC_HUMANHSP74_HUMANBioGRID, IntAct15198682 15358145 17992192 29128334 details
SODC_HUMANFIBA_HUMANIntAct32814053 details
SODC_HUMANKC1D_HUMANIntAct32814053 details
SODC_HUMANTBB5_HUMANIntAct32814053 details
SODC_HUMANPRS6A_HUMANIntAct32814053 details
SODC_HUMANLSM8_HUMANIntAct32814053 details
SODC_HUMANCO9_HUMANIntAct32814053 details
SODC_HUMANBCL2_HUMANBioGRID, HPRD, IntAct15233914 32814053 details
SODC_HUMANGBB2_HUMANIntAct32814053 details
SODC_HUMANZMYM6_HUMANIntAct32814053 details
SODC_HUMANHXC4_HUMANIntAct32814053 details
SODC_HUMANRSSA_HUMANIntAct32814053 details
SODC_HUMANCRBA2_HUMANIntAct32814053 details
SODC_HUMANITBP1_HUMANIntAct32814053 details
SODC_HUMANSGSM1_HUMANIntAct32814053 details
SODC_HUMANTPM2_HUMANIntAct32814053 details
SODC_HUMANANXA8_HUMANIntAct32814053 details
SODC_HUMANIN35_HUMANIntAct32814053 details
SODC_HUMANSF3B3_HUMANIntAct32814053 details
SODC_HUMANUBP2_HUMANIntAct32814053 details
SODC_HUMANDAB2_HUMANIntAct32814053 details
SODC_HUMANBACD2_HUMANIntAct32814053 details
SODC_HUMANZXDC_HUMANIntAct32814053 details
SODC_HUMANSEM1_HUMANIntAct32814053 details
SODC_HUMANRBBP4_HUMANIntAct32814053 details
SODC_HUMANSP6_HUMANIntAct32814053 details
SODC_HUMANTERF2_HUMANIntAct32814053 details
SODC_HUMANPRS6B_HUMANIntAct32814053 details
SODC_HUMANPP2BA_HUMANHPRD, IntAct11513882 32814053 details
SODC_HUMANOTUB1_HUMANIntAct32814053 details
SODC_HUMANSYK_HUMANHPRD, IntAct18715867 32814053 details
SODC_HUMANPSB8_HUMANIntAct32814053 details
SODC_HUMANAP2B1_HUMANIntAct32814053 details
SODC_HUMANHNRLL_HUMANIntAct32814053 details
SODC_HUMANCBLB_HUMANIntAct32814053 details
SODC_HUMANUBB_HUMANIntAct32814053 details
SODC_HUMANSPT22_HUMANIntAct32814053 details
SODC_HUMANENKUR_HUMANIntAct32814053 details
SODC_HUMANPDZ1I_HUMANIntAct32814053 details
SODC_HUMANBAK_HUMANIntAct32814053 details
SODC_HUMANZSCA1_HUMANIntAct32814053 details
SODC_HUMANGPSM3_HUMANIntAct32814053 details
SODC_HUMANARL16_HUMANIntAct32814053 details
SODC_HUMANKLH36_HUMANIntAct32814053 details
SODC_HUMANRN19A_HUMANBioGRID, HPRD, IntAct12145308 17157513 17666395 32814053 details
SODC_HUMANCF141_HUMANIntAct32814053 details
SODC_HUMANRYBP_HUMANIntAct32814053 details
SODC_HUMANKKCC1_HUMANIntAct32814053 details
SODC_HUMANHUMMR_HUMANIntAct32814053 details
SODC_HUMANSYMPK_HUMANIntAct32814053 details
SODC_HUMANTMX1_HUMANIntAct32814053 details
SODC_HUMANMPND_HUMANIntAct32814053 details
SODC_HUMANOTU7B_HUMANIntAct32814053 details
SODC_HUMANLMBL3_HUMANIntAct32814053 details
SODC_HUMANPBX4_HUMANIntAct32814053 details
SODC_HUMANLNX2_HUMANIntAct32814053 details
SODC_HUMANIQEC1_HUMANIntAct32814053 details
SODC_HUMANRN112_HUMANIntAct32814053 details
SODC_HUMANDYLT1_HUMANBioGRID21252941 details
SODC_HUMANRN111_HUMANIntAct32814053 details
SODC_HUMANKBTB4_HUMANIntAct32814053 details
SODC_HUMANCRYAB_HUMANBioGRID22993064 details
SODC_HUMANCOMD1_HUMANBioGRID20595380 24691167 details
SODC_HUMANSYUA_HUMANBioGRID26643113 details
SODC_HUMANWDR61_HUMANIntAct32814053 details
SODC_HUMANLDH6B_HUMANBioGRID, IntAct26344197 32814053 details
SODC_HUMANTBL1R_HUMANIntAct32814053 details
SODC_HUMANRPP25_HUMANIntAct32814053 details
SODC_HUMANSTAC3_HUMANIntAct32814053 details
SODC_HUMANZMAT2_HUMANIntAct32814053 details
SODC_HUMANUBE3A_HUMANBioGRID23040663 details
SODC_HUMANMARH5_HUMANBioGRID19741096 details
SODC_HUMANAMFR_HUMANBioGRID19661182 details
SODC_HUMANNBR1_HUMANMINT21252941 details
SODC_HUMANG3P_HUMANBioGRID, IntAct26344197 29128334 details
SODC_HUMANEF1D_HUMANBioGRID, IntAct20195357 29128334 details
SODC_HUMANGIMA6_HUMANIntAct32814053 details
SODC_HUMANDCTN2_HUMANMINT21252941 details
SODC_HUMANMYCB2_HUMANMINT21653829 details
SODC_HUMANHSP7C_HUMANBioGRID15358145 28215707 details
SODC_HUMANBAG3_HUMANMINT21252941 details
SODC_HUMANDC2L1_HUMANMINT21252941 details
SODC_HUMANDNJB1_HUMANHPRD11457725 details
SODC_HUMANCHIP_HUMANBioGRID15358145 17157513 details
SODC_HUMANSSRD_HUMANBioGRID14684739 details
SODC_HUMANSQSTM_HUMANMINT21252941 details
SODC_HUMANOPTN_HUMANBioGRID23178947 32014991 details
SODC_HUMANPSMD4_HUMANBioGRID15358145 details
SODC_HUMANLAMP2_HUMANMINT21252941 details
SODC_HUMANDCAF4_HUMANBioGRID32014991 details
SODC_HUMANHDAC6_HUMANBioGRID23580651 details
SODC_HUMANHXB2_HUMANHPRD16079151 details
SODC_HUMANHECW1_HUMANBioGRID14684739 details
SODC_HUMANUBC_HUMANBioGRID15198682 details