Entity Details

Primary name ADA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00813
EntryNameADA_HUMAN
FullNameAdenosine deaminase
TaxID9606
Evidenceevidence at protein level
Length363
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesADA

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001821 histamine secretion
GO:0001829 trophectodermal cell differentiation
GO:0001883 purine nucleoside binding
GO:0001889 liver development
GO:0001890 placenta development
GO:0002314 germinal center B cell differentiation
GO:0002636 positive regulation of germinal center formation
GO:0002686 negative regulation of leukocyte migration
GO:0002906 negative regulation of mature B cell apoptotic process
GO:0004000 adenosine deaminase activity
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006154 adenosine catabolic process
GO:0006157 deoxyadenosine catabolic process
GO:0006196 AMP catabolic process
GO:0007155 cell adhesion
GO:0007568 aging
GO:0008270 zinc ion binding
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010460 positive regulation of heart rate
GO:0016020 membrane
GO:0030054 cell junction
GO:0030890 positive regulation of B cell proliferation
GO:0032261 purine nucleotide salvage
GO:0032839 dendrite cytoplasm
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0033197 response to vitamin E
GO:0033632 regulation of cell-cell adhesion mediated by integrin
GO:0042110 T cell activation
GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043025 neuronal cell body
GO:0043101 purine-containing compound salvage
GO:0043103 hypoxanthine salvage
GO:0043278 response to morphine
GO:0045987 positive regulation of smooth muscle contraction
GO:0046059 dAMP catabolic process
GO:0046061 dATP catabolic process
GO:0046103 inosine biosynthetic process
GO:0046111 xanthine biosynthetic process
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0048286 lung alveolus development
GO:0048541 Peyer's patch development
GO:0048566 embryonic digestive tract development
GO:0050728 negative regulation of inflammatory response
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0060169 negative regulation of adenosine receptor signaling pathway
GO:0060205 cytoplasmic vesicle lumen
GO:0060407 negative regulation of penile erection
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070256 negative regulation of mucus secretion

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Cytoplasmic vesicle lumen
Lysosome

Domains

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DomainNameCategoryType
IPR001365 Adenosine/AMP deaminase domainDomainDomain
IPR006330 Adenosine/adenine deaminaseFamilyFamily
IPR006650 Adenosine/AMP deaminase active siteSiteActive site
IPR028893 Adenosine deaminaseFamilyFamily
IPR032466 Metal-dependent hydrolaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00194 VidarabineDrugbanksmall molecule
DB00277 TheophyllineDrugbanksmall molecule
DB00552 PentostatinDrugbanksmall molecule
DB00640 AdenosineDrugbanksmall molecule
DB00974 Edetic acidSwissprotsmall molecule
DB00975 DipyridamoleDrugbanksmall molecule
DB01280 NelarabineDrugbanksmall molecule
DB02096 FR221647Drugbanksmall molecule
DB02472 7,8-dihydroinosineDrugbanksmall molecule
DB02616 FR117016Drugbanksmall molecule
DB02830 FR236913Drugbanksmall molecule
DB03015 6-hydroxy-1,6-dihydro purine nucleosideDrugbanksmall molecule
DB03220 FR-234938Drugbanksmall molecule
DB03370 FR239087Drugbanksmall molecule
DB03572 FR230513Drugbanksmall molecule
DB04218 1-Deaza-AdenosineDrugbanksmall molecule
DB04440 NebularineDrugbanksmall molecule
DB05057 ErdosteineSwissprotsmall molecule
DB07711 (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-olDrugbanksmall molecule
DB07783 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDEDrugbanksmall molecule
DB07785 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDEDrugbanksmall molecule
DB07786 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDEDrugbanksmall molecule
DB14598 Edetate calcium disodium anhydrousSwissprotsmall molecule
DB14600 Edetate disodium anhydrousSwissprotsmall molecule