Entity Details

Primary name CAH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00918
EntryNameCAH2_HUMAN
FullNameCarbonic anhydrase 2
TaxID9606
Evidenceevidence at protein level
Length260
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesCA2

GO terms

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GOName
GO:0001822 kidney development
GO:0004064 arylesterase activity
GO:0004089 carbonate dehydratase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0006730 one-carbon metabolic process
GO:0008270 zinc ion binding
GO:0009268 response to pH
GO:0010043 response to zinc ion
GO:0015670 carbon dioxide transport
GO:0015701 bicarbonate transport
GO:0016323 basolateral plasma membrane
GO:0016836 hydro-lyase activity
GO:0030424 axon
GO:0032849 positive regulation of cellular pH reduction
GO:0038166 angiotensin-activated signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043627 response to estrogen
GO:0044070 regulation of anion transport
GO:0045177 apical part of cell
GO:0045672 positive regulation of osteoclast differentiation
GO:0045780 positive regulation of bone resorption
GO:0048545 response to steroid hormone
GO:0051453 regulation of intracellular pH
GO:0070062 extracellular exosome
GO:0071498 cellular response to fluid shear stress
GO:2001150 positive regulation of dipeptide transmembrane transport

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR001148 Alpha carbonic anhydrase domainDomainDomain
IPR018338 Carbonic anhydrase, alpha-class, conserved siteSiteConserved site
IPR023561 Carbonic anhydrase, alpha-classFamilyFamily
IPR036398 Alpha carbonic anhydrase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00232 MethyclothiazideDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00311 EthoxzolamideDrugbanksmall molecule
DB00391 SulpirideDrugbanksmall molecule
DB00436 BendroflumethiazideDrugbanksmall molecule
DB00482 CelecoxibDrugbanksmall molecule
DB00562 BenzthiazideDrugbanksmall molecule
DB00580 ValdecoxibDrugbanksmall molecule
DB00606 CyclothiazideDrugbanksmall molecule
DB00695 FurosemideDrugbanksmall molecule
DB00703 MethazolamideDrugbanksmall molecule
DB00774 HydroflumethiazideDrugbanksmall molecule
DB00819 AcetazolamideDrugbanksmall molecule
DB00869 DorzolamideDrugbanksmall molecule
DB00880 ChlorothiazideDrugbanksmall molecule
DB00909 ZonisamideDrugbanksmall molecule
DB01021 TrichlormethiazideDrugbanksmall molecule
DB01031 EthinamateDrugbanksmall molecule
DB01119 DiazoxideDrugbanksmall molecule
DB01144 DiclofenamideDrugbanksmall molecule
DB01194 BrinzolamideDrugbanksmall molecule
DB01325 QuinethazoneDrugbanksmall molecule
DB01671 p-Hydroxymercuribenzoic acidDrugbanksmall molecule
DB01748 N-Benzyl-4-Sulfamoyl-BenzamideDrugbanksmall molecule
DB01784 4-FlourobenzenesulfonamideDrugbanksmall molecule
DB01942 Formic acidDrugbanksmall molecule
DB01964 AL5424Drugbanksmall molecule
DB02069 N-(2-Flouro-Benzyl)-4-Sulfamoyl-BenzamideDrugbanksmall molecule
DB02087 3,5-DifluorobenzenesulfonamideDrugbanksmall molecule
DB02220 AL7089ADrugbanksmall molecule
DB02221 4-(Aminosulfonyl)-N-[(2,4,6-Trifluorophenyl)Methyl]-BenzamideDrugbanksmall molecule
DB02292 IrosustatDrugbanksmall molecule
DB02429 4-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-BenzamideDrugbanksmall molecule
DB02479 (R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-BenzamideDrugbanksmall molecule
DB02535 Aminodi(Ethyloxy)EthylaminocarbonylbenzenesulfonamideDrugbanksmall molecule
DB02602 AL7182Drugbanksmall molecule
DB02610 N-(2,3,4,5,6-Pentaflouro-Benzyl)-4-Sulfamoyl-BenzamideDrugbanksmall molecule
DB02679 CyanamideDrugbanksmall molecule
DB02861 4-(Aminosulfonyl)-N-[(3,4,5-Trifluorophenyl)Methyl]-BenzamideDrugbanksmall molecule
DB02866 DansylamideDrugbanksmall molecule
DB02894 Sulfamic Acid 2,3-O-(1-Methylethylidene)-4,5-O-Sulfonyl-Beta-Fructopyranose EsterDrugbanksmall molecule
DB02986 N-(2-Thienylmethyl)-2,5-ThiophenedisulfonamideDrugbanksmall molecule
DB03039 4-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-BenzamideDrugbanksmall molecule
DB03221 AL7099ADrugbanksmall molecule
DB03262 Al-6619, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Hydroxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]Drugbanksmall molecule
DB03270 2,6-DifluorobenzenesulfonamideDrugbanksmall molecule
DB03294 1-Methyl-3-Oxo-1,3-Dihydro-Benzo[C]Isothiazole-5-Sulfonic Acid AmideDrugbanksmall molecule
DB03333 (4-sulfamoyl-phenyl)-thiocarbamic acid O-(2-thiophen-3-yl-ethyl) esterDrugbanksmall molecule
DB03385 4-MethylimidazoleDrugbanksmall molecule
DB03526 AL5927Drugbanksmall molecule
DB03594 1,2,4-TriazoleDrugbanksmall molecule
DB03596 N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-BenzamideDrugbanksmall molecule
DB03598 Al-6629, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Methoxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]Drugbanksmall molecule
DB03697 4-Sulfonamide-[1-(4-Aminobutane)]BenzamideDrugbanksmall molecule
DB03844 N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-BenzamideDrugbanksmall molecule
DB03877 AL-4623Drugbanksmall molecule
DB03904 UreaDrugbanksmall molecule
DB03950 (S)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-BenzamideDrugbanksmall molecule
DB03975 Mercuribenzoic AcidDrugbanksmall molecule
DB04002 4-Sulfonamide-[4-(Thiomethylaminobutane)]BenzamideDrugbanksmall molecule
DB04081 (4s-Trans)-4-(Methylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-DioxideDrugbanksmall molecule
DB04089 AL5300Drugbanksmall molecule
DB04180 4-(Aminosulfonyl)-N-[(2,4-Difluorophenyl)Methyl]-BenzamideDrugbanksmall molecule
DB04203 3-Mercuri-4-AminobenzenesulfonamideDrugbanksmall molecule
DB04371 AL6528Drugbanksmall molecule
DB04394 3-Nitro-4-(2-Oxo-Pyrrolidin-1-Yl)-BenzenesulfonamideDrugbanksmall molecule
DB04549 4-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-BenzamideDrugbanksmall molecule
DB04600 4-[(3-BROMO-4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLEDrugbanksmall molecule
DB04601 4-[(4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLEDrugbanksmall molecule
DB04763 1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUMDrugbanksmall molecule
DB06891 5-{[(4-AMINO-3-CHLORO-5-FLUOROPHENYL)SULFONYL]AMINO}-1,3,4-THIADIAZOLE-2-SULFONAMIDEDrugbanksmall molecule
DB06954 2-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamateDrugbanksmall molecule
DB07048 N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamideDrugbanksmall molecule
DB07050 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamideDrugbanksmall molecule
DB07363 THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE)Drugbanksmall molecule
DB07467 (S)-IndapamideDrugbanksmall molecule
DB07476 N-[4-(AMINOSULFONYL)PHENYL]-2-MERCAPTOBENZAMIDEDrugbanksmall molecule
DB07596 (17beta)-17-(cyanomethyl)-2-methoxyestra-1(10),2,4-trien-3-yl sulfamateDrugbanksmall molecule
DB07632 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamideDrugbanksmall molecule
DB07710 PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDEDrugbanksmall molecule
DB07742 N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDEDrugbanksmall molecule
DB08046 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamideDrugbanksmall molecule
DB08083 2-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamideDrugbanksmall molecule
DB08155 N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDEDrugbanksmall molecule
DB08156 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACIDDrugbanksmall molecule
DB08157 ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATEDrugbanksmall molecule
DB08165 indane-5-sulfonamideDrugbanksmall molecule
DB08202 4-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDEDrugbanksmall molecule
DB08301 N-({[4-(AMINOSULFONYL)PHENYL]AMINO}CARBONYL)-4-METHYLBENZENESULFONAMIDEDrugbanksmall molecule
DB08329 SulthiameDrugbanksmall molecule
DB08416 (9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATEDrugbanksmall molecule
DB08418 (4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamateDrugbanksmall molecule
DB08645 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDEDrugbanksmall molecule
DB08659 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamideDrugbanksmall molecule
DB08765 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDEDrugbanksmall molecule
DB08782 4-(2-AMINOETHYL)BENZENESULFONAMIDEDrugbanksmall molecule
DB08846 Ellagic acidDrugbanksmall molecule
DB09460 Sodium carbonateDrugbanksmall molecule
DB09472 Sodium sulfateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule