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Entity Details
Primary name
SPTA1_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
P02549
EntryName
SPTA1_HUMAN
FullName
Spectrin alpha chain, erythrocytic 1
TaxID
9606
Evidence
evidence at protein level
Length
2419
SequenceStatus
complete
DateCreated
1986-07-21
DateModified
2021-06-02
Ontological Relatives
Genes
SPTA1
GO terms
Show/Hide Table
GO
Name
GO:0000165
MAPK cascade
GO:0002260
lymphocyte homeostasis
GO:0005200
structural constituent of cytoskeleton
GO:0005509
calcium ion binding
GO:0005829
cytosol
GO:0006779
porphyrin-containing compound biosynthetic process
GO:0006888
endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007009
plasma membrane organization
GO:0007015
actin filament organization
GO:0007411
axon guidance
GO:0008091
spectrin
GO:0008360
regulation of cell shape
GO:0014731
spectrin-associated cytoskeleton
GO:0015629
actin cytoskeleton
GO:0030097
hemopoiesis
GO:0030424
axon
GO:0031235
intrinsic component of the cytoplasmic side of the plasma membrane
GO:0032092
positive regulation of protein binding
GO:0032437
cuticular plate
GO:0042102
positive regulation of T cell proliferation
GO:0051015
actin filament binding
GO:0051693
actin filament capping
Subcellular Location
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Subcellular Location
Cytoplasm
Domains
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Domain
Name
Category
Type
IPR001452
SH3 domain
Domain
Domain
IPR002017
Spectrin repeat
Repeat
Repeat
IPR002048
EF-hand domain
Domain
Domain
IPR011992
EF-hand domain pair
Family
Homologous superfamily
IPR014837
EF-hand, Ca insensitive
Domain
Domain
IPR018159
Spectrin/alpha-actinin
Repeat
Repeat
IPR036028
SH3-like domain superfamily
Family
Homologous superfamily
Diseases
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Drugs
Show/Hide Table
Interactions
68 interactions
Interactor
Partner
Sources
Publications
Link
SPTA1_HUMAN
ABI1_HUMAN
HPRD, IntAct
9593709
details
SPTA1_HUMAN
SPTB2_HUMAN
IntAct
12820899
details
SPTA1_HUMAN
SPTB1_HUMAN
BioGRID, HPRD, IntAct, UniProt
12820899
1634521
20197550
details
SPTA1_HUMAN
EVL_HUMAN
HPRD, MINT
16336193
details
SPTA1_HUMAN
VASP_HUMAN
HPRD, MINT
16336193
details
SPTA1_HUMAN
ENAH_HUMAN
HPRD, MINT
16336193
details
SPTA1_HUMAN
TNFL6_HUMAN
BioGRID, IntAct
19807924
details
SPTA1_HUMAN
ODF3B_HUMAN
BioGRID, IntAct
32296183
details
SPTA1_HUMAN
K2C75_HUMAN
BioGRID, IntAct
32296183
details
SPTA1_HUMAN
BCKD_HUMAN
BioGRID, IntAct
32296183
details
SPTA1_HUMAN
TSH2_HUMAN
BioGRID, IntAct
32296183
details
SPTA1_HUMAN
THIOM_HUMAN
BioGRID, IntAct
32296183
details
SPTA1_HUMAN
DGC6L_HUMAN
BioGRID, IntAct
32296183
details
SPTA1_HUMAN
PKP2_HUMAN
BioGRID, IntAct
32296183
details
SPTA1_HUMAN
CC185_HUMAN
BioGRID, IntAct
32296183
details
SPTA1_HUMAN
G45IP_HUMAN
BioGRID, IntAct
32296183
details
SPTA1_HUMAN
ZN326_HUMAN
BioGRID, IntAct
32296183
details
SPTA1_HUMAN
EXOS5_HUMAN
BioGRID, IntAct
32296183
details
SPTA1_HUMAN
ADA10_HUMAN
UniProt
25036101
details
SPTA1_HUMAN
SL9A2_HUMAN
BioGRID, HPRD
10187839
details
SPTA1_HUMAN
ABL1_HUMAN
BioGRID
9593709
details
SPTA1_HUMAN
ANK1_HUMAN
BioGRID
15929114
2971657
details
SPTA1_HUMAN
PLEC_HUMAN
BioGRID, HPRD
3027087
details
SPTA1_HUMAN
1433T_HUMAN
BioGRID
15161933
details
SPTA1_HUMAN
CU058_HUMAN
BioGRID
32296183
details
SPTA1_HUMAN
FANCA_HUMAN
BioGRID
12571280
16889989
details
SPTA1_HUMAN
XPF_HUMAN
BioGRID
12571280
16889989
details
SPTA1_HUMAN
EZRI_HUMAN
BioGRID
14625392
details
SPTA1_HUMAN
NCOA3_HUMAN
BioGRID
16051665
details
SPTA1_HUMAN
PTN22_HUMAN
BioGRID
16461343
details
SPTA1_HUMAN
MYBB_HUMAN
BioGRID
18548008
details
SPTA1_HUMAN
PTPRO_HUMAN
BioGRID
23533167
details
SPTA1_HUMAN
GAN_HUMAN
BioGRID
26460568
details
SPTA1_HUMAN
SPTA1_HUMAN
BioGRID
12672815
details
SPTA1_HUMAN
UBP11_HUMAN
BioGRID
28040451
details
SPTA1_HUMAN
SMCA4_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
ROA2_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
SMCA2_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
ERCC5_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
ERPG3_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
ERCC6_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
FACD2_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
RAD50_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
FANCJ_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
ERCC3_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
MRE11_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
XRCC5_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
ERCC2_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
SPTN4_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
XRCC6_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
RFA1_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
LMNA_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
PML_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
FANCG_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
FANCC_HUMAN
BioGRID, HPRD
10551855
16889989
details
SPTA1_HUMAN
RD23B_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
FANCF_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
XPA_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
RSSA_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
RAD51_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
ERCC1_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
EMD_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
XRCC2_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
RFA2_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
E41L3_HUMAN
BioGRID
16889989
details
SPTA1_HUMAN
ACTS_HUMAN
BioGRID, HPRD
16889989
2936753
details
SPTA1_HUMAN
SPTN2_HUMAN
HPRD
10852813
details
SPTA1_HUMAN
ADDA_HUMAN
HPRD
3600811
8626479
details
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