Entity Details

Primary name CRP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02741
EntryNameCRP_HUMAN
FullNameC-reactive protein
TaxID9606
Evidenceevidence at protein level
Length224
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesCRP

GO terms

Show/Hide Table
GOName
GO:0001849 complement component C1q complex binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0006958 complement activation, classical pathway
GO:0008228 opsonization
GO:0010628 positive regulation of gene expression
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010888 negative regulation of lipid storage
GO:0030169 low-density lipoprotein particle binding
GO:0032677 regulation of interleukin-8 production
GO:0032930 positive regulation of superoxide anion generation
GO:0032945 negative regulation of mononuclear cell proliferation
GO:0033265 choline binding
GO:0042310 vasoconstriction
GO:0042802 identical protein binding
GO:0044793 negative regulation by host of viral process
GO:0045087 innate immune response
GO:0050750 low-density lipoprotein particle receptor binding
GO:0050830 defense response to Gram-positive bacterium

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR001759 Pentraxin-relatedFamilyFamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR030476 Pentaxin, conserved siteSiteConserved site

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB03945 N,N,N-Trimethyl-2-(phosphonooxy)ethanaminiumDrugbanksmall molecule
DB05744 CRx-139Drugbanksmall molecule

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
CRP_HUMANFCN2_HUMANMINT17581635 details
CRP_HUMANMK03_HUMANBioGRID, IntAct18624398 details
CRP_HUMANMK01_HUMANBioGRID, IntAct21988832 details
CRP_HUMANDHE3_HUMANBioGRID, IntAct21988832 details
CRP_HUMANESS2_HUMANBioGRID, IntAct21988832 details
CRP_HUMANLAMC3_HUMANBioGRID, IntAct21988832 details
CRP_HUMANRL13A_HUMANBioGRID, IntAct21988832 details
CRP_HUMANJIP2_HUMANBioGRID, IntAct25814554 details
CRP_HUMANGMPPA_HUMANBioGRID, IntAct25416956 details
CRP_HUMANCRP_HUMANDIP, HPRD, IntAct12037301 16642000 18786923 19084272 19680263 19850925 265538 details
CRP_HUMANCFAH_HUMANBioGRID, HPRD, IntAct10490997 17293598 17339482 17399790 18786923 19084272 19680263 19850925 20042240 21930971 28533443 29374201 details
CRP_HUMANFHR4_HUMANIntAct19084272 20042240 28533443 details
CRP_HUMANFHR1_HUMANIntAct28533443 details
CRP_HUMANFHR3_HUMANIntAct20042240 28533443 details
CRP_HUMANFCN1_HUMANUniProt21037097 details
CRP_HUMANC1QA_HUMANBioGRID10490997 details
CRP_HUMANFINC_HUMANBioGRID, HPRD6693419 details
CRP_HUMANSAMP_HUMANBioGRID, HPRD1477104 8144569 details
CRP_HUMANH11_HUMANBioGRID, HPRD1989977 details
CRP_HUMANH2A2C_HUMANBioGRID1989977 details
CRP_HUMANUBE3A_HUMANBioGRID32545848 details
CRP_HUMANFCG2A_HUMANHPRD, IntAct10675363 17785206 details
CRP_HUMANFCG2C_HUMANIntAct17785206 details
CRP_HUMANFFAR2_HUMANUniProt21037097 details
CRP_HUMANRU17_HUMANBioGRID, HPRD2477447 details
CRP_HUMANFCGR1_HUMANHPRD12471137 details
CRP_HUMANFCG2B_HUMANHPRD12471137 details
CRP_HUMANH2A1_HUMANHPRD1989977 details
CRP_HUMANGPVI_HUMANHPRD11027634 details
CRP_HUMANLEP_HUMANHPRD16582918 details