Entity Details

Primary name PRIO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04156
EntryNamePRIO_HUMAN
FullNameMajor prion protein
TaxID9606
Evidenceevidence at protein level
Length253
SequenceStatuscomplete
DateCreated1986-11-01
DateModified2021-06-02

Ontological Relatives

GenesPRNP

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001933 negative regulation of protein phosphorylation
GO:0002020 protease binding
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005539 glycosaminoglycan binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006878 cellular copper ion homeostasis
GO:0006979 response to oxidative stress
GO:0007611 learning or memory
GO:0007616 long-term memory
GO:0008017 microtubule binding
GO:0009986 cell surface
GO:0010955 negative regulation of protein processing
GO:0014069 postsynaptic density
GO:0015631 tubulin binding
GO:0016234 inclusion body
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0019898 extrinsic component of membrane
GO:0031362 anchored component of external side of plasma membrane
GO:0031648 protein destabilization
GO:0031802 type 5 metabotropic glutamate receptor binding
GO:0031965 nuclear membrane
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032703 negative regulation of interleukin-2 production
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0044877 protein-containing complex binding
GO:0045048 protein insertion into ER membrane
GO:0045121 membrane raft
GO:0046007 negative regulation of activated T cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051260 protein homooligomerization
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070062 extracellular exosome
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071280 cellular response to copper ion
GO:0090314 positive regulation of protein targeting to membrane
GO:0090647 modulation of age-related behavioral decline
GO:0097062 dendritic spine maintenance
GO:0098794 postsynapse
GO:1900449 regulation of glutamate receptor signaling pathway
GO:1901216 positive regulation of neuron death
GO:1902430 negative regulation of amyloid-beta formation
GO:1902938 regulation of intracellular calcium activated chloride channel activity
GO:1902951 negative regulation of dendritic spine maintenance
GO:1902992 negative regulation of amyloid precursor protein catabolic process
GO:1903136 cuprous ion binding
GO:1904645 response to amyloid-beta
GO:1904646 cellular response to amyloid-beta
GO:1905664 regulation of calcium ion import across plasma membrane
GO:1990535 neuron projection maintenance

Subcellular Location

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Subcellular Location
Cell membrane
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000817 Prion proteinFamilyFamily
IPR022416 Prion/Doppel protein, beta-ribbon domainDomainDomain
IPR025860 Major prion protein N-terminal domainDomainDomain
IPR036924 Prion/Doppel beta-ribbon domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00759 TetracyclineDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule

Interactions

131 interactions

InteractorPartnerSourcesPublicationsLink
PRIO_HUMANBAG6_HUMANBioGRID, HPRD, IntAct16169070 details
PRIO_HUMANT22D4_HUMANBioGRID, HPRD, IntAct16713569 details
PRIO_HUMANPSA3_HUMANBioGRID, HPRD, IntAct16713569 details
PRIO_HUMANPRIO_HUMANDIP, IntAct, MINT16286452 18025469 18436646 19204296 19278656 19927125 21920025 32284600 32514176 details
PRIO_HUMANA4_HUMANIntAct16286452 23236467 24028865 32814053 details
PRIO_HUMANPIMRE_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANPLK3_HUMANBioGRID, IntAct18482256 details
PRIO_HUMAN3MG_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANHXA1_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANBAZ2B_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANCASK_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANCG050_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANSURF2_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANSCNM1_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANTYMOS_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANRBM22_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANCC149_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANTSLP_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANDDX47_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANZKSC8_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANMARK4_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANZN408_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANTBPL1_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANABT1_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANRL41_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANZN740_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANFHL1_HUMANBioGRID, IntAct, UniProt18482256 28671123 details
PRIO_HUMANCWC15_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANTM237_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANIEX1_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANP33MX_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANMYOME_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANPTH_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANMTG1_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANRHG15_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANUTP4_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANAGO1_HUMANBioGRID, DIP, IntAct18482256 22484317 details
PRIO_HUMANWDR5_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANADAP2_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANPP14A_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANLST2_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANCIRBP_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANNHP2_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANPYM1_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANF27E3_HUMANIntAct18482256 details
PRIO_HUMANLIPB2_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANCN37_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANFGF13_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANAIFM3_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANRNPC3_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANNOB1_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANDYRK3_HUMANBioGRID, IntAct18482256 details
PRIO_HUMANHD_HUMANIntAct17500595 32814053 details
PRIO_HUMANPAR2_HUMANBioGRID, MINT28298427 details
PRIO_HUMANFZD7_HUMANBioGRID, MINT28298427 details
PRIO_HUMANADRB2_HUMANBioGRID, MINT28298427 details
PRIO_HUMANCCR1_HUMANBioGRID, MINT28298427 details
PRIO_HUMANPTAFR_HUMANBioGRID, MINT28298427 details
PRIO_HUMANVATB2_HUMANBioGRID, UniProt21301993 29791485 details
PRIO_HUMANSTIP1_HUMANBioGRID, HPRD, UniProt12093732 29791485 details
PRIO_HUMANGRB2_HUMANBioGRID, HPRD, UniProt11571277 29791485 details
PRIO_HUMANNCAM1_HUMANBioGRID, HPRD, UniProt15146195 27535221 29791485 details
PRIO_HUMANSAMD3_HUMANIntAct32814053 details
PRIO_HUMANATLA1_HUMANIntAct32814053 details
PRIO_HUMANCLUS_HUMANBioGRID, HPRD15146195 18786636 details
PRIO_HUMANBIP_HUMANBioGRID, HPRD10970892 15146195 details
PRIO_HUMANTRI15_HUMANBioGRID25450970 details
PRIO_HUMANLMNA_HUMANBioGRID24623722 details
PRIO_HUMANHAX1_HUMANBioGRID21301993 details
PRIO_HUMANMMAD_HUMANBioGRID21301993 details
PRIO_HUMANCRYAB_HUMANBioGRID21301993 details
PRIO_HUMANSTAR5_HUMANBioGRID21301993 details
PRIO_HUMANAPLP1_HUMANBioGRID, HPRD15146195 21301993 details
PRIO_HUMANKIFA3_HUMANBioGRID21301993 details
PRIO_HUMANPSB5_HUMANBioGRID21301993 details
PRIO_HUMANFBSP1_HUMANBioGRID21301993 details
PRIO_HUMANFBLN5_HUMANBioGRID21301993 details
PRIO_HUMANNIPS2_HUMANBioGRID21301993 details
PRIO_HUMANPUR9_HUMANBioGRID21301993 details
PRIO_HUMANDOCK7_HUMANBioGRID21301993 details
PRIO_HUMANWDR61_HUMANBioGRID21301993 details
PRIO_HUMANSC31A_HUMANBioGRID21301993 details
PRIO_HUMANGRM5_HUMANBioGRID25148681 details
PRIO_HUMANPPARG_HUMANIntAct20195357 details
PRIO_HUMANTAU_HUMANIntAct24028865 details
PRIO_HUMANAGO2_HUMANDIP22484317 details
PRIO_HUMANPRDX1_HUMANUniProt28671123 details
PRIO_HUMANZA2G_HUMANUniProt28671123 details
PRIO_HUMANCSTN1_HUMANBioGRID, HPRD, UniProt15146195 29791485 details
PRIO_HUMANPDIA1_HUMANBioGRID, HPRD, UniProt15146195 29791485 details
PRIO_HUMANMAG_HUMANBioGRID, HPRD, UniProt15146195 29791485 details
PRIO_HUMANL1CAM_HUMANBioGRID, HPRD, UniProt15146195 29791485 details
PRIO_HUMANSRRM2_HUMANBioGRID16159877 details
PRIO_HUMANHSP74_HUMANBioGRID20964628 details
PRIO_HUMANARF1_HUMANBioGRID25896910 details
PRIO_HUMANCSK21_HUMANBioGRID, HPRD11062072 28900035 details
PRIO_HUMANZBED3_HUMANBioGRID28900035 details
PRIO_HUMAN1433T_HUMANBioGRID28900035 details
PRIO_HUMANPABP1_HUMANBioGRID28900035 29791485 details
PRIO_HUMANPABP4_HUMANBioGRID28900035 details
PRIO_HUMANCH60_HUMANBioGRID, HPRD28900035 8676499 details
PRIO_HUMANCYLD_HUMANBioGRID28900035 details
PRIO_HUMANHS90A_HUMANBioGRID28900035 details
PRIO_HUMANRSSA_HUMANBioGRID28759037 28900035 details
PRIO_HUMANPSMD2_HUMANBioGRID28900035 details
PRIO_HUMANAMFR_HUMANBioGRID28759037 details
PRIO_HUMANACHA7_HUMANBioGRID20837487 details
PRIO_HUMANNOS1_HUMANBioGRID11032878 details
PRIO_HUMANDAG1_HUMANBioGRID11032878 details
PRIO_HUMANDMD_HUMANBioGRID11032878 details
PRIO_HUMANSNTA1_HUMANBioGRID11032878 details
PRIO_HUMANDCE1_HUMANBioGRID11032878 details
PRIO_HUMANSYPH_HUMANBioGRID11032878 details
PRIO_HUMANPLMN_HUMANHPRD11100730 details
PRIO_HUMANCAV1_HUMANHPRD10988071 details
PRIO_HUMANNCAM2_HUMANHPRD15146195 details
PRIO_HUMANDYN1_HUMANHPRD15146195 details
PRIO_HUMANAPBB1_HUMANHPRD15146195 details
PRIO_HUMANADA23_HUMANHPRD15146195 details
PRIO_HUMANSPRL1_HUMANHPRD15146195 details
PRIO_HUMANCNTN1_HUMANHPRD15146195 details
PRIO_HUMANOPCM_HUMANHPRD15146195 details
PRIO_HUMANNECT1_HUMANHPRD15146195 details
PRIO_HUMANLSAMP_HUMANHPRD15146195 details
PRIO_HUMANMOG_HUMANHPRD15146195 details
PRIO_HUMANERI3_HUMANHPRD11571277 details
PRIO_HUMANAPOE_HUMANHPRD15146195 details
PRIO_HUMANCSK22_HUMANHPRD11062072 details
PRIO_HUMANCSK2B_HUMANHPRD11062072 details
PRIO_HUMANDPP6_HUMANHPRD15146195 details
PRIO_HUMANAPLP2_HUMANHPRD15146195 details