Entity Details

Primary name IF2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05198
EntryNameIF2A_HUMAN
FullNameEukaryotic translation initiation factor 2 subunit 1
TaxID9606
Evidenceevidence at protein level
Length315
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesEIF2S1

GO terms

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GOName
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005844 polysome
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0006413 translational initiation
GO:0007568 aging
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0032057 negative regulation of translational initiation in response to stress
GO:0033290 eukaryotic 48S preinitiation complex
GO:0034063 stress granule assembly
GO:0034198 cellular response to amino acid starvation
GO:0034599 cellular response to oxidative stress
GO:0034605 cellular response to heat
GO:0034644 cellular response to UV
GO:0034976 response to endoplasmic reticulum stress
GO:0036499 PERK-mediated unfolded protein response
GO:0043022 ribosome binding
GO:0043614 multi-eIF complex
GO:0044207 translation initiation ternary complex
GO:0045202 synapse
GO:0046777 protein autophosphorylation
GO:0055085 transmembrane transport
GO:0070062 extracellular exosome
GO:0097451 glial limiting end-foot
GO:1901216 positive regulation of neuron death
GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity
GO:1990737 response to manganese-induced endoplasmic reticulum stress
GO:2000676 positive regulation of type B pancreatic cell apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003029 S1 domainDomainDomain
IPR011488 Translation initiation factor 2, alpha subunitFamilyFamily
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR022967 RNA-binding domain, S1DomainDomain
IPR024054 Translation initiation factor 2, alpha subunit, middle domain superfamilyFamilyHomologous superfamily
IPR024055 Translation initiation factor 2, alpha subunit, C-terminalFamilyHomologous superfamily
IPR044126 IF2a, S1-like domainDomainDomain

Diseases

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Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
IF2A_HUMANIF2B_HUMANBioGRID, HPRD, IntAct, MINT16288713 16932749 22863883 22939629 26186194 26344197 28514442 30699057 details
IF2A_HUMANPP1G_HUMANIntAct17274640 details
IF2A_HUMANKPCA_HUMANBioGRID, MINT17290288 21368187 details
IF2A_HUMANIF2G_HUMANBioGRID, IntAct16288713 22863883 22939629 26344197 30699057 details
IF2A_HUMANE2AK2_HUMANBioGRID, DIP, HPRD, IntAct, MINT10542257 11985496 12882984 16288713 1677563 17290288 18971339 19364808 21368187 8099444 9431994 9819435 details
IF2A_HUMANCSK21_HUMANBioGRID, IntAct22113938 details
IF2A_HUMANDDX3X_HUMANUniProt18596238 22323517 details
IF2A_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
IF2A_HUMANVAC14_HUMANBioGRID, IntAct32296183 details
IF2A_HUMANANM7_HUMANBioGRID, IntAct30699057 32296183 details
IF2A_HUMANACTN1_HUMANBioGRID, IntAct32296183 details
IF2A_HUMANPP1A_HUMANIntAct26095357 details
IF2A_HUMANEI2BA_HUMANBioGRID, HPRD8887689 9446619 details
IF2A_HUMANE2AK3_HUMANBioGRID, HPRD10542257 11555640 16288713 16720581 1677563 8099443 9819435 details
IF2A_HUMANTERT_HUMANBioGRID23741361 details
IF2A_HUMAN1433S_HUMANBioGRID, HPRD17361185 details
IF2A_HUMANCDC37_HUMANBioGRID12930845 details
IF2A_HUMANHS90A_HUMANBioGRID12930845 details
IF2A_HUMANIF4G2_HUMANMINT16932749 details
IF2A_HUMANLYAR_HUMANIntAct17353931 details
IF2A_HUMANTRAF6_HUMANIntAct17353931 details
IF2A_HUMANPR15A_HUMANBioGRID, HPRD, IntAct12556489 26095357 29109149 details
IF2A_HUMANEI2BB_HUMANDIP, HPRD31048492 8887689 details
IF2A_HUMANRENT1_HUMANBioGRID18423202 details
IF2A_HUMANITA4_HUMANBioGRID22623428 details
IF2A_HUMANEI2BD_HUMANBioGRID, HPRD16288713 26344197 8887689 details
IF2A_HUMANSYVN1_HUMANBioGRID29233968 details
IF2A_HUMANCMTR1_HUMANBioGRID30320910 details
IF2A_HUMANKPCD_HUMANHPRD10542257 11555640 1677563 9819435 details
IF2A_HUMANMELK_HUMANHPRD16216881 details
IF2A_HUMANIF1AX_HUMANHPRD12514125 details
IF2A_HUMANCASP3_HUMANHPRD10432301 10734073 details
IF2A_HUMANCASP6_HUMANHPRD10432301 10734073 details
IF2A_HUMANP52K_HUMANHPRD10542257 11555640 1677563 9819435 details
IF2A_HUMANE2AK4_HUMANHPRD10504407 details
IF2A_HUMANE2AK1_HUMANHPRD10542257 1677563 9819435 details
IF2A_HUMANPDIA1_HUMANHPRD1677563 details
IF2A_HUMANEI2BG_HUMANHPRD16288713 details