Entity Details

Primary name INSR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06213
EntryNameINSR_HUMAN
FullNameInsulin receptor
TaxID9606
Evidenceevidence at protein level
Length1382
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesINSR

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001540 amyloid-beta binding
GO:0001934 positive regulation of protein phosphorylation
GO:0002092 positive regulation of receptor internalization
GO:0003007 heart morphogenesis
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005009 insulin-activated receptor activity
GO:0005159 insulin-like growth factor receptor binding
GO:0005198 structural molecule activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005899 insulin receptor complex
GO:0005901 caveola
GO:0005975 carbohydrate metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006898 receptor-mediated endocytosis
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007275 multicellular organism development
GO:0007612 learning
GO:0007613 memory
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009897 external side of plasma membrane
GO:0010008 endosome membrane
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019087 transformation of host cell by virus
GO:0019904 protein domain specific binding
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0031994 insulin-like growth factor I binding
GO:0031995 insulin-like growth factor II binding
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032590 dendrite membrane
GO:0032809 neuronal cell body membrane
GO:0032869 cellular response to insulin stimulus
GO:0033674 positive regulation of kinase activity
GO:0038024 cargo receptor activity
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0043243 positive regulation of protein-containing complex disassembly
GO:0043410 positive regulation of MAPK cascade
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043559 insulin binding
GO:0043560 insulin receptor substrate binding
GO:0044877 protein-containing complex binding
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045821 positive regulation of glycolytic process
GO:0045840 positive regulation of mitotic nuclear division
GO:0045995 regulation of embryonic development
GO:0046326 positive regulation of glucose import
GO:0046777 protein autophosphorylation
GO:0048639 positive regulation of developmental growth
GO:0051425 PTB domain binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0060267 positive regulation of respiratory burst
GO:0070062 extracellular exosome
GO:0097062 dendritic spine maintenance
GO:0097242 amyloid-beta clearance
GO:0150104 transport across blood-brain barrier
GO:1990535 neuron projection maintenance

Subcellular Location

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Subcellular Location
Cell membrane
Late endosome
Lysosome

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016246 Tyrosine-protein kinase, insulin-like receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily
IPR040969 Insulin receptor, trans-membrane domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00030 Insulin humanDrugbankbiotech
DB00046 Insulin lisproDrugbankbiotech
DB00047 Insulin glargineDrugbankbiotech
DB00071 Insulin porkDrugbankbiotech
DB01277 MecaserminDrugbankbiotech
DB01306 Insulin aspartDrugbankbiotech
DB01307 Insulin detemirDrugbankbiotech
DB01309 Insulin glulisineDrugbankbiotech
DB03909 Adenosine-5'-[Beta, Gamma-Methylene]TriphosphateDrugbanksmall molecule
DB05115 NN344Drugbanksmall molecule
DB05120 AT1391Drugbanksmall molecule
DB08513 [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACIDDrugbanksmall molecule
DB09129 Chromic chlorideDrugbanksmall molecule
DB09564 Insulin degludecDrugbankbiotech
DB12010 FostamatinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB14751 Mecasermin rinfabateDrugbankbiotech

Interactions

116 interactions

InteractorPartnerSourcesPublicationsLink
INSR_HUMANMD2L1_HUMANBioGRID, HPRD, IntAct, MINT32296183 9092546 details
INSR_HUMANGRB10_HUMANBioGRID, DIP, HPRD, MINT10871840 12493740 12551896 15664450 19648926 7479769 8621530 9006901 9369444 9506989 details
INSR_HUMANIRS2_HUMANBioGRID, HPRD, MINT8626379 8662806 9195949 details
INSR_HUMANIRS1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10455177 11606564 11781100 15629149 16582879 17167487 25667086 7499194 7935368 8626379 8662806 details
INSR_HUMANCRKL_HUMANHPRD, IntAct15522217 details
INSR_HUMANCRK_HUMANHPRD, IntAct15522217 details
INSR_HUMANSHC1_HUMANBioGRID, HPRD, IntAct, MINT10482988 10764799 10803466 10816433 10896916 10921922 11075717 12237775 15629149 7499194 8702728 9083103 9121430 9446569 9593725 9710204 9741627 details
INSR_HUMAN1433B_HUMANHPRD, IntAct15629149 details
INSR_HUMANGRB14_HUMANBioGRID, DIP, HPRD, IntAct, MINT11726652 16582879 16934761 19648926 24535599 details
INSR_HUMANPTN1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11163213 11506178 11579209 11726652 12237455 12634852 14722096 15588987 16271887 16582879 16926280 17092689 17159996 17481567 19029027 21806020 8826975 8999839 9355745 details
INSR_HUMANPLCG1_HUMANBioGRID, HPRD, MINT11796522 14568990 22974441 9593725 details
INSR_HUMANP85A_HUMANBioGRID, HPRD, MINT10500481 11796522 1334490 14729945 15629149 7659087 8276809 8385099 8567177 9593725 details
INSR_HUMANPTN11_HUMANBioGRID, HPRD, MINT7493946 8135823 8895367 9593725 details
INSR_HUMANPTPRC_HUMANHPRD, IntAct1373652 19167335 details
INSR_HUMANPTPRK_HUMANBioGRID, IntAct19167335 26186194 28514442 details
INSR_HUMANPTPRG_HUMANIntAct19167335 details
INSR_HUMANPTPRB_HUMANIntAct19167335 details
INSR_HUMANPTPRJ_HUMANIntAct19167335 details
INSR_HUMANPTPRO_HUMANIntAct19167335 details
INSR_HUMANPTN12_HUMANHPRD, IntAct19167335 8454633 details
INSR_HUMANSTA5B_HUMANBioGRID, HPRD, MINT10830280 12456798 9122188 9428692 details
INSR_HUMANSH2B1_HUMANBioGRID, HPRD, MINT10594240 15767667 9742218 details
INSR_HUMANIRF7_HUMANBioGRID, IntAct21988832 details
INSR_HUMANTEAD1_HUMANBioGRID, IntAct21988832 details
INSR_HUMANENPP1_HUMANbhf-ucl, BioGRID, HPRD10615944 11289049 details
INSR_HUMANIGF1_HUMANbhf-ucl, DIP26027733 8452530 details
INSR_HUMANPGS2_HUMANmatrixdb24389353 details
INSR_HUMANK1H1_HUMANBioGRID, IntAct25416956 details
INSR_HUMANINSR_HUMANBioGRID, DIP, HPRD11401470 16271887 16957736 18278056 2033070 23302862 26853939 29512653 7806540 8496180 8504096 details
INSR_HUMANARRB2_HUMANBioGRID, DIP19122674 details
INSR_HUMANINS_HUMANDIP, HPRD23302862 2550426 29512653 details
INSR_HUMANPTN3_HUMANDIP25728925 details
INSR_HUMANDUS18_HUMANBioGRID, MINT28065597 details
INSR_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
INSR_HUMANSTYX_HUMANBioGRID, MINT28065597 details
INSR_HUMANDUS19_HUMANBioGRID, MINT28065597 details
INSR_HUMANCSK_HUMANBioGRID, HPRD10026153 details
INSR_HUMANFRS2_HUMANBioGRID, HPRD10650943 details
INSR_HUMANSOCS3_HUMANBioGRID, HPRD11071852 12560330 15514089 details
INSR_HUMANFETUA_HUMANBioGRID, HPRD7906861 details
INSR_HUMANRASH_HUMANBioGRID, HPRD3109943 details
INSR_HUMANSMAD2_HUMANBioGRID, HPRD9092546 details
INSR_HUMANVAV_HUMANBioGRID, HPRD7535775 details
INSR_HUMANGRB7_HUMANBioGRID, HPRD10803466 details
INSR_HUMANHNRPQ_HUMANBioGRID, HPRD11994298 details
INSR_HUMANSH2B2_HUMANBioGRID, HPRD10196204 15031295 17620296 details
INSR_HUMANSOCS1_HUMANBioGRID, HPRD11342531 15169905 29991678 details
INSR_HUMANDOK1_HUMANBioGRID, HPRD11551902 details
INSR_HUMANSQSTM_HUMANBioGRID26043024 9564850 details
INSR_HUMANMARH1_HUMANBioGRID27577745 details
INSR_HUMANCHIP_HUMANBioGRID28431247 details
INSR_HUMANGRDN_HUMANBioGRID25187647 details
INSR_HUMANERBB2_HUMANBioGRID30898150 details
INSR_HUMANTRI72_HUMANBioGRID30586741 details
INSR_HUMANSOCS2_HUMANHPRD10453981 details
INSR_HUMANGAB1_HUMANHPRD10978177 9658397 details
INSR_HUMANP55G_HUMANHPRD9524259 details
INSR_HUMANSRBS1_HUMANBioGRID, HPRD, IntAct11374898 details
INSR_HUMANRHOB_HUMANBioGRID, MINT14722096 34079125 details
INSR_HUMANRASA1_HUMANBioGRID, HPRD, MINT1331107 9593725 details
INSR_HUMANAGAP2_HUMANMINT21720388 details
INSR_HUMANPTN2_HUMANHPRD, MINT12612081 15192089 15588985 details
INSR_HUMANPTN6_HUMANBioGRID, HPRD, MINT12468540 28065597 7512963 8114715 8692915 details
INSR_HUMANDUS14_HUMANMINT28065597 details
INSR_HUMANASM3B_HUMANIntAct31217420 details
INSR_HUMANCAV1_HUMANBioGRID, HPRD, IntAct10598578 31217420 details
INSR_HUMANMK01_HUMANBioGRID11409918 details
INSR_HUMANMK03_HUMANBioGRID, HPRD11409918 details
INSR_HUMANKHDR1_HUMANBioGRID, HPRD10437794 11604231 details
INSR_HUMANGRB2_HUMANBioGRID9083103 details
INSR_HUMANKPCD_HUMANBioGRID, HPRD11266508 12031982 details
INSR_HUMANVAV3_HUMANBioGRID, HPRD11094073 details
INSR_HUMANINSRR_HUMANBioGRID, HPRD8916919 details
INSR_HUMANSHIP2_HUMANBioGRID12504111 17620296 details
INSR_HUMANSNX6_HUMANBioGRID, HPRD11279102 details
INSR_HUMANSNX1_HUMANBioGRID, HPRD9819414 details
INSR_HUMANSNX2_HUMANBioGRID, HPRD9819414 details
INSR_HUMANSNX4_HUMANBioGRID, HPRD9819414 details
INSR_HUMANJAK2_HUMANBioGRID, HPRD12456798 8912646 details
INSR_HUMANHGS_HUMANBioGRID17445799 details
INSR_HUMANSOCS6_HUMANBioGRID, HPRD11342531 details
INSR_HUMANSTA5A_HUMANBioGRID, HPRD12456798 details
INSR_HUMANJAK1_HUMANBioGRID, HPRD12456798 9492017 details
INSR_HUMANSNX17_HUMANBioGRID23382219 details
INSR_HUMANSNX27_HUMANBioGRID23382219 details
INSR_HUMANPUR9_HUMANBioGRID25687571 details
INSR_HUMANHACD3_HUMANBioGRID25687571 details
INSR_HUMANAAPK1_HUMANBioGRID25687571 details
INSR_HUMANAAPK2_HUMANBioGRID25687571 details
INSR_HUMANKIF5A_HUMANBioGRID25687571 details
INSR_HUMANPPM1A_HUMANBioGRID28065597 details
INSR_HUMANPPM1F_HUMANBioGRID28065597 details
INSR_HUMANMPZL2_HUMANBioGRID28065597 details
INSR_HUMANSSH1_HUMANBioGRID28065597 details
INSR_HUMANPPAC_HUMANBioGRID, HPRD1304913 9299573 details
INSR_HUMANIGF1R_HUMANBioGRID, HPRD27684187 7895674 details
INSR_HUMANRIN1_HUMANBioGRID12783862 details
INSR_HUMANRACK1_HUMANBioGRID, HPRD11964397 16382134 details
INSR_HUMANADRB2_HUMANHPRD8557631 details
INSR_HUMANCALM1_HUMANHPRD12153558 8639568 details
INSR_HUMANCALM2_HUMANHPRD12153558 8639568 details
INSR_HUMANCALM3_HUMANHPRD12153558 8639568 details
INSR_HUMANARF1_HUMANHPRD9197239 details
INSR_HUMANCEAM1_HUMANHPRD10805733 11694516 7592607 7626603 details
INSR_HUMANSRC_HUMANHPRD15337529 details
INSR_HUMANCAV3_HUMANHPRD9756945 details
INSR_HUMANRHG26_HUMANHPRD7836419 details
INSR_HUMANDOK4_HUMANHPRD12730241 details
INSR_HUMANIGF2_HUMANHPRD9722981 details
INSR_HUMANRAF1_HUMANHPRD11409918 details
INSR_HUMANCBL_HUMANHPRD10635327 11997497 details
INSR_HUMANKPCA_HUMANHPRD7926007 8463287 details
INSR_HUMANPTPRF_HUMANHPRD11158333 1321126 15588985 details
INSR_HUMANFABP4_HUMANHPRD1648089 8463311 details
INSR_HUMANDOK5_HUMANHPRD12730241 details
INSR_HUMANK1C27_HUMANHPRD15629149 details