Entity Details

Primary name HYEP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07099
EntryNameHYEP_HUMAN
FullNameEpoxide hydrolase 1
TaxID9606
Evidenceevidence at protein level
Length455
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesEPHX1

GO terms

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GOName
GO:0004301 epoxide hydrolase activity
GO:0005789 endoplasmic reticulum membrane
GO:0006805 xenobiotic metabolic process
GO:0009636 response to toxic substance
GO:0016021 integral component of membrane
GO:0019369 arachidonic acid metabolic process
GO:0019439 aromatic compound catabolic process
GO:0033961 cis-stilbene-oxide hydrolase activity
GO:0097176 epoxide metabolic process

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR000073 Alpha/beta hydrolase fold-1DomainDomain
IPR000639 Epoxide hydrolase-likeFamilyFamily
IPR016292 Epoxide hydrolaseFamilyFamily
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
607748 OMIMFamilial hypercholanemia (FHCA)A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00252 PhenytoinDrugbanksmall molecule
DB00808 IndapamideDrugbanksmall molecule

Interactions

3 interactions