Entity Details

Primary name CAN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07384
EntryNameCAN1_HUMAN
FullNameCalpain-1 catalytic subunit
TaxID9606
Evidenceevidence at protein level
Length714
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesCAPN1

GO terms

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GOName
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006508 proteolysis
GO:0008233 peptidase activity
GO:0008284 positive regulation of cell population proliferation
GO:0016020 membrane
GO:0016241 regulation of macroautophagy
GO:0022617 extracellular matrix disassembly
GO:0032801 receptor catabolic process
GO:0043312 neutrophil degranulation
GO:0050790 regulation of catalytic activity
GO:0060056 mammary gland involution
GO:0070062 extracellular exosome
GO:0070268 cornification
GO:0097264 self proteolysis
GO:1904813 ficolin-1-rich granule lumen
GO:2000310 regulation of NMDA receptor activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR001300 Peptidase C2, calpain, catalytic domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR022682 Peptidase C2, calpain, large subunit, domain IIIDomainDomain
IPR022683 Peptidase C2, calpain, domain IIIDomainDomain
IPR022684 Peptidase C2, calpain familyFamilyFamily
IPR029643 Calpain-1FamilyFamily
IPR033883 Calpain subdomain IIIDomainDomain
IPR036213 Calpain large subunit, domain III superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB04276 4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azaniumDrugbanksmall molecule
DB04653 N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamideDrugbanksmall molecule
DB07627 (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDEDrugbanksmall molecule

Interactions

70 interactions

InteractorPartnerSourcesPublicationsLink
CAN1_HUMANRCAN1_HUMANIntAct15935327 details
CAN1_HUMANPTN1_HUMANMINT19712109 9407132 details
CAN1_HUMANCLC4G_HUMANBioGRID, IntAct18624398 details
CAN1_HUMANSTAT3_HUMANBioGRID, IntAct21988832 details
CAN1_HUMANEZRI_HUMANMINT22805611 details
CAN1_HUMANTIRAP_HUMANInnateDB23023391 details
CAN1_HUMANVIME_HUMANBioGRID, HPRD, IntAct12358155 28514442 details
CAN1_HUMANKCY_HUMANIntAct32814053 details
CAN1_HUMANBAD_HUMANIntAct32814053 details
CAN1_HUMANOPTN_HUMANIntAct32814053 details
CAN1_HUMANA4_HUMANIntAct32814053 details
CAN1_HUMANPSN2_HUMANBioGRID, HPRD10677567 9852298 details
CAN1_HUMANIKBA_HUMANBioGRID, HPRD10521480 details
CAN1_HUMANFANCA_HUMANBioGRID20518497 details
CAN1_HUMANFANCG_HUMANBioGRID20518497 details
CAN1_HUMANRAD21_HUMANBioGRID21876002 22145905 details
CAN1_HUMANANM5_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANSH3BG_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANFHL2_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANTINAL_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANCREG1_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANECHM_HUMANBioGRID, HPRD12358155 22863883 details
CAN1_HUMANNDUB7_HUMANBioGRID12358155 details
CAN1_HUMANSLIT3_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANALAT1_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANCATC_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANPTGDS_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANTLE5_HUMANBioGRID12358155 details
CAN1_HUMANNF2L1_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANACTC_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANMYPC3_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANACTN2_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANDESM_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANCO1A1_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANSPTN1_HUMANBioGRID, HPRD8993318 details
CAN1_HUMANHNRPD_HUMANBioGRID15231747 details
CAN1_HUMANATG5_HUMANBioGRID16998475 details
CAN1_HUMANATX3_HUMANBioGRID28334907 details
CAN1_HUMANTAU_HUMANBioGRID22535953 details
CAN1_HUMANS22A1_HUMANBioGRID31318583 details
CAN1_HUMANUFSP2_HUMANHPRD12358155 details
CAN1_HUMANLTOR1_HUMANHPRD12358155 details
CAN1_HUMANCO3A1_HUMANHPRD12358155 details
CAN1_HUMANSYNE1_HUMANHPRD12358155 details
CAN1_HUMANCPNS1_HUMANBioGRID, HPRD, IntAct, MINT12591934 19712109 26496610 28514442 details
CAN1_HUMANNMDE2_HUMANBioGRID, HPRD, IntAct10846184 25241761 details
CAN1_HUMANPAR1_HUMANBioGRID, HPRD, IntAct10978167 25241761 details
CAN1_HUMANICAL_HUMANBioGRID, HPRD, IntAct12684003 20679491 26496610 28514442 details
CAN1_HUMANKNG1_HUMANBioGRID, HPRD, IntAct26186194 28514442 3038169 8253784 details
CAN1_HUMANFANCC_HUMANBioGRID20518497 details
CAN1_HUMANPALB2_HUMANBioGRID20518497 details
CAN1_HUMANGAS2_HUMANBioGRID20679491 details
CAN1_HUMANHIF1A_HUMANBioGRID19458911 details
CAN1_HUMANITA4_HUMANBioGRID22623428 details
CAN1_HUMANP53_HUMANBioGRID, HPRD12432277 23443559 details
CAN1_HUMANNMT1_HUMANBioGRID16530191 details
CAN1_HUMANFXL12_HUMANBioGRID26124079 details
CAN1_HUMANAKT1_HUMANBioGRID24462114 details
CAN1_HUMANIL1A_HUMANHPRD7499244 details
CAN1_HUMANITB3_HUMANHPRD7592818 details
CAN1_HUMANB2CL1_HUMANHPRD12000759 details
CAN1_HUMANINP4A_HUMANHPRD9110986 details
CAN1_HUMANBID_HUMANHPRD12000759 details
CAN1_HUMANCD5R1_HUMANHPRD10830966 details
CAN1_HUMANCASPE_HUMANHPRD12200134 details
CAN1_HUMANGBG12_HUMANHPRD7493986 details
CAN1_HUMANSPTB2_HUMANHPRD9989581 details
CAN1_HUMANCBL_HUMANHPRD8695851 details
CAN1_HUMANPAR2_HUMANHPRD10978167 details
CAN1_HUMANARF6_HUMANHPRD16737952 details