Entity Details

Primary name CATB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07858
EntryNameCATB_HUMAN
FullNameCathepsin B
TaxID9606
Evidenceevidence at protein level
Length339
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesCTSB

GO terms

Show/Hide Table
GOName
GO:0002224 toll-like receptor signaling pathway
GO:0004197 cysteine-type endopeptidase activity
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular anatomical structure
GO:0005764 lysosome
GO:0006508 proteolysis
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016324 apical plasma membrane
GO:0030574 collagen catabolic process
GO:0030855 epithelial cell differentiation
GO:0036021 endolysosome lumen
GO:0042470 melanosome
GO:0042981 regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0043394 proteoglycan binding
GO:0048471 perinuclear region of cytoplasm
GO:0050790 regulation of catalytic activity
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0097067 cellular response to thyroid hormone stimulus
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

Show/Hide Table
Subcellular Location
Apical cell membrane
Lysosome
Melanosome
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR000668 Peptidase C1A, papain C-terminalDomainDomain
IPR012599 Peptidase C1A, propeptideDomainDomain
IPR025660 Cysteine peptidase, histidine active siteSiteActive site
IPR025661 Cysteine peptidase, asparagine active siteSiteActive site
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB02108 2-Aminoethanimidic AcidDrugbanksmall molecule
DB02148 3-Amino-4-Oxybenzyl-2-ButanoneDrugbanksmall molecule
DB02685 3-MethylphenylalanineDrugbanksmall molecule
DB02855 N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineDrugbanksmall molecule
DB03329 2-PyridinethiolDrugbanksmall molecule
DB03588 Diphenylacetic acidDrugbanksmall molecule
DB04126 N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-ButaneDrugbanksmall molecule
DB04579 N-{[(2S,3S)-3-(Ethoxycarbonyl)-2-oxiranyl]carbonyl}-L-threonyl-L-isoleucineDrugbanksmall molecule
DB07160 N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINEDrugbanksmall molecule
DB07219 BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATEDrugbanksmall molecule
DB07223 METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATEDrugbanksmall molecule
DB07224 N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINEDrugbanksmall molecule
DB07225 N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINEDrugbanksmall molecule
DB07231 N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINEDrugbanksmall molecule
DB14962 Trastuzumab deruxtecanDrugbankbiotech

Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
CATB_HUMANBAG6_HUMANBioGRID, HPRD, IntAct16169070 details
CATB_HUMANRGS2_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
CATB_HUMANATL4_HUMANHPRD, MINT16364318 details
CATB_HUMANAMBP_HUMANBioGRID, MINT16364318 26208400 details
CATB_HUMANSPHK1_HUMANHPRD, MINT15710602 17064696 details
CATB_HUMANCYTA_HUMANBioGRID, HPRD, MINT10353845 14503883 20860624 9585570 details
CATB_HUMANMLH1_HUMANBioGRID, IntAct20706999 details
CATB_HUMANANXA7_HUMANBioGRID, MINT21900206 details
CATB_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
CATB_HUMANF118B_HUMANBioGRID, MINT21900206 details
CATB_HUMANSPY2_HUMANBioGRID, MINT21900206 details
CATB_HUMANSTK11_HUMANBioGRID, MINT25640309 details
CATB_HUMANHSPB2_HUMANbhf-ucl, BioGRID26465331 details
CATB_HUMANBOD1_HUMANIntAct32814053 details
CATB_HUMANCYTB_HUMANBioGRID, HPRD11514663 14503883 26208400 details
CATB_HUMANCYTC_HUMANBioGRID, HPRD11115496 14503883 1996959 22693552 7890620 details
CATB_HUMANS10AA_HUMANBioGRID, HPRD10777578 details
CATB_HUMANANXA2_HUMANBioGRID, HPRD10777578 26208400 details
CATB_HUMANUBQL4_HUMANBioGRID11162551 details
CATB_HUMANSH3K1_HUMANBioGRID16733801 details
CATB_HUMANA4_HUMANBioGRID21832049 details
CATB_HUMANPARP1_HUMANBioGRID11536009 details
CATB_HUMANHNRPD_HUMANBioGRID15231747 details
CATB_HUMANXRN1_HUMANBioGRID15231747 details
CATB_HUMANERPG3_HUMANBioGRID31722399 details
CATB_HUMANERCC6_HUMANBioGRID31722399 details
CATB_HUMANSPIT2_HUMANHPRD16364318 details
CATB_HUMANSRPX2_HUMANHPRD18718938 details
CATB_HUMANDISC1_HUMANIntAct31413325 details
CATB_HUMANEFMT3_HUMANBioGRID23349634 details
CATB_HUMANGCR_HUMANBioGRID28611094 31182584 details
CATB_HUMANMMP9_HUMANBioGRID26208400 details
CATB_HUMANSAMP_HUMANBioGRID26208400 details
CATB_HUMANINS_HUMANBioGRID, HPRD32457219 6351842 details
CATB_HUMANCD151_HUMANBioGRID22495828 details
CATB_HUMANSLPI_HUMANHPRD11435427 details
CATB_HUMANAPOE_HUMANHPRD12057992 details
CATB_HUMANOSTCN_HUMANHPRD9076588 details
CATB_HUMANPGCA_HUMANHPRD1326552 details
CATB_HUMANRENI_HUMANHPRD1597471 2061332 3542996 9928950 details
CATB_HUMANCYTF_HUMANHPRD9632704 9733783 details
CATB_HUMANSPB13_HUMANHPRD10512713 details
CATB_HUMANMARCS_HUMANHPRD9295331 details
CATB_HUMANUROK_HUMANHPRD1900515 details
CATB_HUMANCATD_HUMANHPRD10876156 details
CATB_HUMANCATB_HUMANHPRD1868826 7718586 details
CATB_HUMANIGF1_HUMANHPRD16051222 details
CATB_HUMANA2MG_HUMANHPRD2476070 details