Entity Details

Primary name RET_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07949
EntryNameRET_HUMAN
FullNameProto-oncogene tyrosine-protein kinase receptor Ret
TaxID9606
Evidenceevidence at protein level
Length1114
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesRET

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0001657 ureteric bud development
GO:0001755 neural crest cell migration
GO:0001838 embryonic epithelial tube formation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006468 protein phosphorylation
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007158 neuron cell-cell adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0007497 posterior midgut development
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0014042 positive regulation of neuron maturation
GO:0030155 regulation of cell adhesion
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0033619 membrane protein proteolysis
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0033674 positive regulation of kinase activity
GO:0035799 ureter maturation
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway
GO:0038023 signaling receptor activity
GO:0042493 response to drug
GO:0042551 neuron maturation
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0045121 membrane raft
GO:0045793 positive regulation of cell size
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048265 response to pain
GO:0048484 enteric nervous system development
GO:0050770 regulation of axonogenesis
GO:0051897 positive regulation of protein kinase B signaling
GO:0060041 retina development in camera-type eye
GO:0060384 innervation
GO:0061146 Peyer's patch morphogenesis
GO:0071300 cellular response to retinoic acid
GO:0072300 positive regulation of metanephric glomerulus development
GO:0097021 lymphocyte migration into lymphoid organs
GO:0098797 plasma membrane protein complex
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cell membrane
Endosome membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002126 Cadherin-likeDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015919 Cadherin-like superfamilyFamilyHomologous superfamily
IPR016249 Tyrosine-protein kinase, Ret receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR040667 Tyrosine-protein kinase receptor Ret, cadherin like domain 3DomainDomain
IPR041163 Ret, cadherin like domain 1DomainDomain
IPR041317 RET cadherin-like domain 4DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00398 SorafenibDrugbanksmall molecule
DB01809 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineDrugbanksmall molecule
DB05294 VandetanibDrugbanksmall molecule
DB08875 CabozantinibDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12742 AmuvatinibDrugbanksmall molecule
DB15685 SelpercatinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
RET_HUMANCBL_HUMANBioGRID, HPRD, MINT12727845 15677445 28794017 32062451 details
RET_HUMANUBIM_HUMANMINT15677445 details
RET_HUMANGRB2_HUMANBioGRID, HPRD, MINT10995764 15677445 32062451 7665556 8183561 9393871 details
RET_HUMANSHC1_HUMANBioGRID, HPRD, MINT15677445 28213521 32062451 8183561 9047384 details
RET_HUMANPLCG1_HUMANBioGRID, HPRD, IntAct, MINT16153436 25241761 32062451 8628282 details
RET_HUMANCASP3_HUMANIntAct10921886 details
RET_HUMANNEMO_HUMANBioGRID, IntAct20098747 details
RET_HUMANCRK_HUMANBioGRID, HPRD, IntAct10208419 25241761 32062451 9393871 details
RET_HUMANLRRK1_HUMANBioGRID, IntAct24947832 29513927 details
RET_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 28460442 31980649 details
RET_HUMANNT2NA_HUMANBioGRID, IntAct25416956 25910212 details
RET_HUMANRET_HUMANBioGRID, DIP, HPRD10445857 11121408 12787916 14711813 15588985 20473317 32062451 8621380 details
RET_HUMANGFRA1_HUMANBioGRID, DIP, HPRD10774729 10829012 20473317 9192898 details
RET_HUMANGAS1_HUMANMINT25888394 details
RET_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
RET_HUMANDUS26_HUMANBioGRID, MINT28065597 details
RET_HUMANDOK5_HUMANBioGRID, HPRD11470823 15286081 details
RET_HUMANPTPRF_HUMANBioGRID11121408 details
RET_HUMANDOK2_HUMANBioGRID, HPRD11470823 details
RET_HUMANDOK4_HUMANBioGRID, HPRD11470823 details
RET_HUMANDOK1_HUMANBioGRID, HPRD12087092 16153436 details
RET_HUMANGRB7_HUMANBioGRID, HPRD8631863 details
RET_HUMANFRS2_HUMANBioGRID, HPRD11360177 32062451 details
RET_HUMANGRB10_HUMANBioGRID, HPRD28794017 7665556 details
RET_HUMANNT2NC_HUMANBioGRID25416956 25910212 details
RET_HUMANNOTC3_HUMANBioGRID25356737 details
RET_HUMANAIP_HUMANBioGRID19366855 32062451 details
RET_HUMANP85A_HUMANBioGRID, HPRD10652352 10995764 32062451 details
RET_HUMANFBX7_HUMANBioGRID27503909 details
RET_HUMANNEDD4_HUMANBioGRID28794017 details
RET_HUMANCTNB1_HUMANBioGRID19223551 32062451 details
RET_HUMANSHC4_HUMANBioGRID28213521 details
RET_HUMANERBB2_HUMANBioGRID30898150 details
RET_HUMANPTPRA_HUMANBioGRID32062451 details
RET_HUMANDOK3_HUMANHPRD11470823 details
RET_HUMANGAB1_HUMANBioGRID, HPRD, IntAct11360177 19914172 32062451 details
RET_HUMANSTAT3_HUMANBioGRID, HPRD, IntAct, MINT11536047 12637586 15485908 25241761 details
RET_HUMANCTND1_HUMANBioGRID, IntAct21357690 32062451 details
RET_HUMANMK01_HUMANBioGRID, HPRD, IntAct16153436 25241761 details
RET_HUMANMK03_HUMANBioGRID, HPRD, IntAct16153436 25241761 details
RET_HUMANSORL_HUMANIntAct23333276 details
RET_HUMANLRIG1_HUMANIntAct29436694 details
RET_HUMANDOK6_HUMANBioGRID, HPRD15286081 details
RET_HUMANSRC_HUMANBioGRID, HPRD10070972 32062451 details
RET_HUMANPDLI7_HUMANBioGRID, HPRD12176011 24466333 details
RET_HUMANNRTN_HUMANBioGRID, HPRD9192898 details
RET_HUMANMCRS1_HUMANBioGRID16186106 details
RET_HUMANCBLC_HUMANBioGRID18753381 24466333 details
RET_HUMANSHAN2_HUMANBioGRID28794017 details
RET_HUMANGDNF_HUMANBioGRID, HPRD32062451 8674117 details
RET_HUMANKAP2_HUMANBioGRID, HPRD11886862 32062451 details
RET_HUMANMK08_HUMANHPRD16153436 details
RET_HUMANMK14_HUMANHPRD16153436 details
RET_HUMANPTN11_HUMANHPRD12959980 details
RET_HUMANSHC3_HUMANHPRD12242309 details
RET_HUMANCBLB_HUMANHPRD16525057 details
RET_HUMANAKAP5_HUMANHPRD11886862 details