Entity Details

Primary name PTPRC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08575
EntryNamePTPRC_HUMAN
FullNameReceptor-type tyrosine-protein phosphatase C
TaxID9606
Evidenceevidence at protein level
Length1306
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesPTPRC

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001779 natural killer cell differentiation
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002639 positive regulation of immunoglobulin production
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005102 signaling receptor binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006469 negative regulation of protein kinase activity
GO:0006470 protein dephosphorylation
GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007159 leukocyte cell-cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0008201 heparin binding
GO:0009897 external side of plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0009986 cell surface
GO:0010332 response to gamma radiation
GO:0010468 regulation of gene expression
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016032 viral process
GO:0016311 dephosphorylation
GO:0019901 protein kinase binding
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030506 ankyrin binding
GO:0030507 spectrin binding
GO:0030667 secretory granule membrane
GO:0030890 positive regulation of B cell proliferation
GO:0031668 cellular response to extracellular stimulus
GO:0031953 negative regulation of protein autophosphorylation
GO:0032059 bleb
GO:0032677 regulation of interleukin-8 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034113 heterotypic cell-cell adhesion
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0043312 neutrophil degranulation
GO:0043395 heparan sulfate proteoglycan binding
GO:0043410 positive regulation of MAPK cascade
GO:0044770 cell cycle phase transition
GO:0044855 plasma membrane raft distribution
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045121 membrane raft
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0048539 bone marrow development
GO:0048864 stem cell development
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050764 regulation of phagocytosis
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0061097 regulation of protein tyrosine kinase activity
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0070062 extracellular exosome
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0098857 membrane microdomain
GO:1903615 positive regulation of protein tyrosine phosphatase activity
GO:1903979 negative regulation of microglial cell activation
GO:1904155 DN2 thymocyte differentiation
GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
GO:2000473 positive regulation of hematopoietic stem cell migration
GO:2000648 positive regulation of stem cell proliferation
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Membrane raft

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR016335 Receptor-type tyrosine-protein phosphatase CFamilyFamily
IPR024739 Protein tyrosine phosphatase, receptor type, N-terminalDomainDomain
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Interactions

78 interactions

InteractorPartnerSourcesPublicationsLink
PTPRC_HUMANLCK_HUMANBioGRID, DIP, HPRD, IntAct, MINT10330160 10369126 11369760 12589038 14625311 15085197 19167335 24463463 7507203 8473339 8576115 8663450 9533446 9973453 details
PTPRC_HUMANPTPRC_HUMANBioGRID, HPRD, MINT10683443 15978577 details
PTPRC_HUMANCADH2_HUMANIntAct19167335 details
PTPRC_HUMANTEC_HUMANIntAct19167335 details
PTPRC_HUMANERBB2_HUMANIntAct19167335 details
PTPRC_HUMANPGFRB_HUMANIntAct19167335 details
PTPRC_HUMANMET_HUMANIntAct19167335 details
PTPRC_HUMANPAXI_HUMANIntAct19167335 details
PTPRC_HUMANCTNB1_HUMANIntAct, MINT12370829 19167335 details
PTPRC_HUMANINSR_HUMANHPRD, IntAct1373652 19167335 details
PTPRC_HUMANTIE1_HUMANIntAct19167335 details
PTPRC_HUMANCSK_HUMANIntAct, MINT19167335 7507203 details
PTPRC_HUMANGAB1_HUMANIntAct19167335 details
PTPRC_HUMANNMDE2_HUMANIntAct19167335 details
PTPRC_HUMANNTRK1_HUMANIntAct19167335 details
PTPRC_HUMANPDPK1_HUMANIntAct19167335 details
PTPRC_HUMANNSF_HUMANIntAct19167335 details
PTPRC_HUMANGHR_HUMANIntAct19167335 details
PTPRC_HUMANEPOR_HUMANIntAct19167335 details
PTPRC_HUMANEGFR_HUMANIntAct19167335 31980649 details
PTPRC_HUMANMK03_HUMANIntAct19167335 details
PTPRC_HUMANTIE2_HUMANIntAct19167335 details
PTPRC_HUMANWASP_HUMANIntAct19167335 details
PTPRC_HUMANACK1_HUMANIntAct19167335 details
PTPRC_HUMANCBL_HUMANIntAct19167335 details
PTPRC_HUMANLEPR_HUMANIntAct19167335 details
PTPRC_HUMANPKP4_HUMANIntAct19167335 details
PTPRC_HUMANITAL_HUMANBioGRID, HPRD, MINT15946252 details
PTPRC_HUMANLEG1_HUMANBioGRID, HPRD, MINT10369126 10490978 details
PTPRC_HUMANUHRF2_HUMANBioGRID, UniProt21952639 details
PTPRC_HUMANSKAP1_HUMANBioGRID, HPRD11909961 details
PTPRC_HUMANGANAB_HUMANBioGRID, HPRD10921916 11564800 9148925 details
PTPRC_HUMANPTCA_HUMANBioGRID, HPRD7499298 8537410 details
PTPRC_HUMANCD2_HUMANBioGRID, HPRD1970422 1976695 details
PTPRC_HUMANCD8A_HUMANBioGRID, HPRD1834739 details
PTPRC_HUMANCD4_HUMANBioGRID, HPRD1834739 details
PTPRC_HUMANCD3Z_HUMANBioGRID, HPRD7526385 details
PTPRC_HUMANLYN_HUMANBioGRID, HPRD10415030 12393728 7516335 details
PTPRC_HUMANRNF11_HUMANBioGRID, HPRD15231748 details
PTPRC_HUMANFYN_HUMANBioGRID, HPRD12589038 14625311 8980254 9368621 9535845 details
PTPRC_HUMANSRC_HUMANBioGRID14625311 details
PTPRC_HUMANMK01_HUMANBioGRID10415025 details
PTPRC_HUMANSEM4D_HUMANBioGRID, HPRD, MINT10648410 11254687 8955171 details
PTPRC_HUMANCD22_HUMANBioGRID, HPRD, MINT10228003 10648410 7537381 details
PTPRC_HUMANCD244_HUMANIntAct23346089 details
PTPRC_HUMANCXCR4_HUMANHPRD, MINT12519755 21912642 details
PTPRC_HUMANPAEP_HUMANBioGRID, HPRD12556471 details
PTPRC_HUMANGLU2B_HUMANBioGRID, HPRD9148925 details
PTPRC_HUMANPLK3_HUMANBioGRID11551930 details
PTPRC_HUMANSLAF1_HUMANBioGRID10229804 details
PTPRC_HUMANCD44_HUMANBioGRID9573028 details
PTPRC_HUMANCD79A_HUMANBioGRID7516335 details
PTPRC_HUMANCD79B_HUMANBioGRID7516335 details
PTPRC_HUMANCD1D_HUMANBioGRID, HPRD10473580 details
PTPRC_HUMANU2AF2_HUMANBioGRID26641092 details
PTPRC_HUMANMK14_HUMANBioGRID10415025 details
PTPRC_HUMANGRB2_HUMANHPRD8570203 details
PTPRC_HUMANCSK21_HUMANHPRD10066810 details
PTPRC_HUMANCSK22_HUMANHPRD10066810 details
PTPRC_HUMANINAR1_HUMANHPRD9403695 details
PTPRC_HUMANEZRI_HUMANHPRD12560083 details
PTPRC_HUMANRASA1_HUMANHPRD8570203 details
PTPRC_HUMANFCG3A_HUMANHPRD8157290 details
PTPRC_HUMANIRS1_HUMANHPRD8557683 details
PTPRC_HUMANJAK1_HUMANHPRD11201744 details
PTPRC_HUMANJAK2_HUMANHPRD11201744 details
PTPRC_HUMANMBL2_HUMANHPRD11564800 details
PTPRC_HUMANPTN6_HUMANHPRD10228003 9368621 details
PTPRC_HUMANTYK2_HUMANHPRD11201744 details
PTPRC_HUMANZAP70_HUMANHPRD7737297 details
PTPRC_HUMANCD28_HUMANHPRD1355979 details
PTPRC_HUMANDPP4_HUMANHPRD1680916 details
PTPRC_HUMANJAK3_HUMANHPRD11994288 details
PTPRC_HUMANLCP2_HUMANHPRD8703037 details
PTPRC_HUMANLIPB2_HUMANHPRD9624153 details
PTPRC_HUMANLSM1_HUMANHPRD8980254 details
PTPRC_HUMANAN32A_HUMANHPRD1655467 details
PTPRC_HUMANLIPA1_HUMANHPRD9624153 details