Entity Details

Primary name IRGM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionA1A4Y4
EntryNameIRGM_HUMAN
FullNameImmunity-related GTPase family M protein
TaxID9606
Evidenceevidence at protein level
Length181
SequenceStatuscomplete
DateCreated2008-03-18
DateModified2021-06-02

Ontological Relatives

GenesIRGM

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0000139 Golgi membrane
GO:0000421 autophagosome membrane
GO:0001891 phagocytic cup
GO:0001934 positive regulation of protein phosphorylation
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0010508 positive regulation of autophagy
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0019901 protein kinase binding
GO:0030670 phagocytic vesicle membrane
GO:0031648 protein destabilization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035458 cellular response to interferon-beta
GO:0042742 defense response to bacterium
GO:0042995 cell projection
GO:0043254 regulation of protein-containing complex assembly
GO:0043539 protein serine/threonine kinase activator activity
GO:0045087 innate immune response
GO:0050700 CARD domain binding
GO:0050821 protein stabilization
GO:0050829 defense response to Gram-negative bacterium
GO:0051434 BH3 domain binding
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
GO:0061635 regulation of protein complex stability
GO:0061739 protein lipidation involved in autophagosome assembly
GO:0061762 CAMKK-AMPK signaling cascade
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0075044 positive regulation by symbiont of host autophagy
GO:0098586 cellular response to virus
GO:1901098 positive regulation of autophagosome maturation

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasmic vesicle
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR007743 Immunity-related GTPases-likeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030385 IRG-type guanine nucleotide-binding (G) domainDomainDomain

Diseases

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