Entity Details

Primary name IL8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10145
EntryNameIL8_HUMAN
FullNameInterleukin-8
TaxID9606
Evidenceevidence at protein level
Length99
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesCXCL8

GO terms

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GOName
GO:0001525 angiogenesis
GO:0002237 response to molecule of bacterial origin
GO:0005153 interleukin-8 receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008009 chemokine activity
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0019722 calcium-mediated signaling
GO:0030155 regulation of cell adhesion
GO:0030593 neutrophil chemotaxis
GO:0031328 positive regulation of cellular biosynthetic process
GO:0031623 receptor internalization
GO:0031640 killing of cells of other organism
GO:0034976 response to endoplasmic reticulum stress
GO:0035556 intracellular signal transduction
GO:0036499 PERK-mediated unfolded protein response
GO:0042119 neutrophil activation
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045236 CXCR chemokine receptor binding
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0048566 embryonic digestive tract development
GO:0050930 induction of positive chemotaxis
GO:0060354 negative regulation of cell adhesion molecule production
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070098 chemokine-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0090023 positive regulation of neutrophil chemotaxis
GO:2000535 regulation of entry of bacterium into host cell

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001089 CXC chemokineFamilyFamily
IPR001811 Chemokine interleukin-8-like domainDomainDomain
IPR018048 CXC chemokine, conserved siteSiteConserved site
IPR028469 Interleukin-8FamilyFamily
IPR033899 CXC Chemokine domainDomainDomain
IPR036048 Chemokine interleukin-8-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05434 ABT-510Drugbanksmall molecule
DB05484 MDX-018Drugbanksmall molecule
DB05855 RivaniclineDrugbanksmall molecule
DB06083 TapinarofDrugbanksmall molecule