Entity Details

Primary name PIM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11309
EntryNamePIM1_HUMAN
FullNameSerine/threonine-protein kinase pim-1
TaxID9606
Evidenceevidence at protein level
Length313
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesPIM1

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007275 multicellular organism development
GO:0008134 transcription factor binding
GO:0019221 cytokine-mediated signaling pathway
GO:0022898 regulation of transmembrane transporter activity
GO:0030145 manganese ion binding
GO:0030212 hyaluronan metabolic process
GO:0043024 ribosomal small subunit binding
GO:0043066 negative regulation of apoptotic process
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043539 protein serine/threonine kinase activator activity
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0050821 protein stabilization
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0070561 vitamin D receptor signaling pathway
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090336 positive regulation of brown fat cell differentiation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902033 regulation of hematopoietic stem cell proliferation
GO:1905062 positive regulation of cardioblast proliferation
GO:1990748 cellular detoxification

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017348 Serine/threonine-protein kinase pim-1/2/3FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB01754 3,4-Dihydroxy-1-Methylquinolin-2(1h)-OneDrugbanksmall molecule
DB02010 StaurosporineDrugbanksmall molecule
DB02656 LY-294002Drugbanksmall molecule
DB03366 ImidazoleDrugbanksmall molecule
DB03650 (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-OneDrugbanksmall molecule
DB03777 Bisindolylmaleimide IDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB04522 DexfosfoserineDrugbanksmall molecule
DB04530 S,S-(2-Hydroxyethyl)ThiocysteineDrugbanksmall molecule
DB04715 IMIDAZOPYRIDAZIN 1Drugbanksmall molecule
DB07151 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-oneDrugbanksmall molecule
DB07242 (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrileDrugbanksmall molecule
DB07524 N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amineDrugbanksmall molecule
DB08022 (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrileDrugbanksmall molecule
DB08166 (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrileDrugbanksmall molecule
DB08230 TricetinDrugbanksmall molecule
DB08705 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILEDrugbanksmall molecule
DB08707 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amineDrugbanksmall molecule
DB08708 N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amineDrugbanksmall molecule
DB08709 2,3-diphenyl-1H-indole-7-carboxylic acidDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

55 interactions

InteractorPartnerSourcesPublicationsLink
PIM1_HUMANGLYC_HUMANBioGRID, HPRD, IntAct16169070 details
PIM1_HUMANABCG2_HUMANIntAct18056989 details
PIM1_HUMANMDM2_HUMANBioGRID, MINT18467333 19166854 details
PIM1_HUMANRS19_HUMANIntAct16266891 details
PIM1_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
PIM1_HUMANTFPT_HUMANBioGRID, IntAct25416956 details
PIM1_HUMANFUMH_HUMANBioGRID, IntAct25416956 details
PIM1_HUMANFXR2_HUMANBioGRID, IntAct25416956 details
PIM1_HUMANBEND7_HUMANBioGRID, IntAct25416956 details
PIM1_HUMANBANP_HUMANBioGRID, IntAct25416956 details
PIM1_HUMANHEXI2_HUMANBioGRID, IntAct25416956 details
PIM1_HUMANZBTB1_HUMANBioGRID, IntAct25416956 details
PIM1_HUMANFOXP3_HUMANIntAct25096571 details
PIM1_HUMANMARK3_HUMANBioGRID, IntAct15319445 26186194 28514442 details
PIM1_HUMANDAPK1_HUMANBioGRID, IntAct29513927 details
PIM1_HUMANKPCA_HUMANMINT30017192 details
PIM1_HUMANKAPCA_HUMANMINT30017192 details
PIM1_HUMANSNX6_HUMANBioGRID, HPRD11279102 11591366 details
PIM1_HUMANSND1_HUMANBioGRID, HPRD9809063 details
PIM1_HUMANMPIP1_HUMANBioGRID, HPRD10373478 12411508 details
PIM1_HUMANNFAC1_HUMANBioGRID, HPRD11823475 details
PIM1_HUMANCBX3_HUMANBioGRID, HPRD10664448 details
PIM1_HUMANCDN1A_HUMANBioGRID, HPRD12431783 details
PIM1_HUMANNUMA1_HUMANBioGRID, HPRD12111331 details
PIM1_HUMANH32_HUMANBioGRID17643117 details
PIM1_HUMANMYC_HUMANBioGRID17643117 28620180 details
PIM1_HUMANSKP2_HUMANBioGRID20663873 details
PIM1_HUMANCDC20_HUMANBioGRID20663873 details
PIM1_HUMANMDR1_HUMANBioGRID20460432 details
PIM1_HUMANFZR1_HUMANBioGRID20663873 details
PIM1_HUMANPIM1_HUMANBioGRID15319445 details
PIM1_HUMANA4_HUMANBioGRID21832049 details
PIM1_HUMANHEN1_HUMANBioGRID25416956 details
PIM1_HUMANPP2AA_HUMANBioGRID17297438 details
PIM1_HUMANH33_HUMANBioGRID28620180 details
PIM1_HUMANSENP1_HUMANBioGRID28620180 details
PIM1_HUMANFBX7_HUMANBioGRID27503909 details
PIM1_HUMANUBC9_HUMANBioGRID28620180 details
PIM1_HUMANBAD_HUMANBioGRID, HPRD16403219 28620180 details
PIM1_HUMANBMX_HUMANIntAct16186805 details
PIM1_HUMANCDN1B_HUMANMINT18593906 details
PIM1_HUMANFOXO3_HUMANMINT18593906 details
PIM1_HUMANHS90B_HUMANIntAct22939624 details
PIM1_HUMANHS90A_HUMANBioGRID, HPRD11237709 15798097 details
PIM1_HUMANCBX1_HUMANBioGRID, HPRD12111331 details
PIM1_HUMANMAX_HUMANBioGRID17643117 details
PIM1_HUMANUB2R1_HUMANBioGRID20663873 details
PIM1_HUMANPIN1_HUMANBioGRID17297438 details
PIM1_HUMANHSP74_HUMANBioGRID15798097 details
PIM1_HUMAN2A5B_HUMANBioGRID17297438 details
PIM1_HUMANPIAS3_HUMANBioGRID28620180 details
PIM1_HUMANPIAS1_HUMANBioGRID28620180 details
PIM1_HUMANPTPRO_HUMANHPRD11368509 details
PIM1_HUMANEPHA3_HUMANHPRD16186805 details
PIM1_HUMANH31T_HUMANHPRD17643117 details