Entity Details

Primary name FGFR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11362
EntryNameFGFR1_HUMAN
FullNameFibroblast growth factor receptor 1
TaxID9606
Evidenceevidence at protein level
Length822
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesFGFR1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001501 skeletal system development
GO:0001764 neuron migration
GO:0001837 epithelial to mesenchymal transition
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010518 positive regulation of phospholipase activity
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016021 integral component of membrane
GO:0016477 cell migration
GO:0017134 fibroblast growth factor binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0031410 cytoplasmic vesicle
GO:0033674 positive regulation of kinase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043009 chordate embryonic development
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0046777 protein autophosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048705 skeletal system morphogenesis
GO:0051897 positive regulation of protein kinase B signaling
GO:0090722 receptor-receptor interaction
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016248 Fibroblast growth factor receptor familyFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR028174 Fibroblast growth factor receptor 1, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041159 Fibroblast growth factor receptor, transmembrane domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00039 PaliferminDrugbankbiotech
DB00398 SorafenibDrugbanksmall molecule
DB01109 HeparinDrugbanksmall molecule
DB02058 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinoneDrugbanksmall molecule
DB05014 XL999Drugbanksmall molecule
DB07525 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridineDrugbanksmall molecule
DB07840 (E)-[4-(3,5-Difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanolDrugbanksmall molecule
DB08577 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONEDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12147 ErdafitinibDrugbanksmall molecule
DB15102 PemigatinibDrugbanksmall molecule
DB15685 SelpercatinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

107 interactions

InteractorPartnerSourcesPublicationsLink
FGFR1_HUMANERBB3_HUMANBioGRID, MINT16273093 details
FGFR1_HUMANFGF2_HUMANBioGRID, DIP, HPRD, IntAct10490103 10748122 10950949 11030354 11786412 14505356 14613973 15096041 15548653 16829530 1697263 17086194 1709094 18199118 19627396 19696444 21693575 22539306 23597562 23597563 26267536 7520751 8609172 8692946 8868466 9174056 details
FGFR1_HUMANCADH1_HUMANBioGRID, IntAct11401320 25241761 27371729 details
FGFR1_HUMANKLOTB_HUMANBioGRID, MINT17623664 19059246 22523080 26272615 details
FGFR1_HUMANP85A_HUMANBioGRID, HPRD, IntAct, MINT15117958 18412956 25241761 8321198 details
FGFR1_HUMANPLCG1_HUMANBioGRID, DIP, HPRD, IntAct, MINT12601080 15117958 1656221 1689310 18022941 19665973 20932831 23063561 25241761 8321198 9660748 details
FGFR1_HUMANCRK_HUMANBioGRID, HPRD, IntAct, MINT10464310 25241761 details
FGFR1_HUMANFGF1_HUMANBioGRID, DIP, HPRD, IntAct, matrixdb, UniProt10336501 10748122 10830168 11030354 11032250 11714710 1309595 1383494 14613973 1697263 1709094 18199118 18261743 18441324 22244757 22955284 25241761 28769084 8321198 8576175 8692946 8756477 9624181 details
FGFR1_HUMANPYRG2_HUMANBioGRID, IntAct21988832 details
FGFR1_HUMANNEDD4_HUMANBioGRID, MINT19953087 21765395 25292214 details
FGFR1_HUMANFRS2_HUMANBioGRID, HPRD, MINT10464310 10629055 11090629 11877385 18022941 21765395 9632781 9660748 details
FGFR1_HUMANKALM_HUMANBioGRID, IntAct15548653 19696444 20874775 23189990 details
FGFR1_HUMANFGFR1_HUMANBioGRID, DIP, HPRD, IntAct10464310 10830168 10918587 11030354 12181353 12601080 1309784 18022941 19224897 19696444 20133753 21621521 22523080 22539306 26272615 26300540 28769084 31980649 7516330 8321198 8622701 8752212 details
FGFR1_HUMANNOSTN_HUMANMINT22751148 details
FGFR1_HUMAN5HT1A_HUMANBioGRID, IntAct22035699 25485703 details
FGFR1_HUMANFGF8_HUMANBioGRID, DIP, HPRD, IntAct10574949 18199118 22244757 25241761 details
FGFR1_HUMANCBP_HUMANBioGRID, HPRD, IntAct15929978 19261810 22539306 25241761 details
FGFR1_HUMANKPYM_HUMANBioGRID, IntAct24606918 25263439 32572027 details
FGFR1_HUMANFGF23_HUMANBioGRID, DIP17086194 19966287 22393163 27879395 details
FGFR1_HUMANMFHA1_HUMANBioGRID, IntAct29513927 details
FGFR1_HUMANFGF4_HUMANBioGRID, HPRD, IntAct10748122 11486033 14613973 details
FGFR1_HUMANFGF6_HUMANBioGRID, HPRD, IntAct14613973 18199118 8663044 details
FGFR1_HUMANFGF9_HUMANBioGRID, HPRD, IntAct10574949 14613973 18199118 details
FGFR1_HUMANPELO_HUMANIntAct32814053 details
FGFR1_HUMANID2_HUMANIntAct32814053 details
FGFR1_HUMANFPPS_HUMANBioGRID, HPRD12020352 details
FGFR1_HUMANFRS3_HUMANBioGRID, HPRD10629055 9660748 details
FGFR1_HUMANNCAM1_HUMANBioGRID, HPRD12121226 12791257 17005551 18261743 details
FGFR1_HUMANSHB_HUMANBioGRID7537362 details
FGFR1_HUMANGRB14_HUMANBioGRID, HPRD10713090 20932831 details
FGFR1_HUMANBNIP2_HUMANBioGRID, HPRD10551883 details
FGFR1_HUMANPTK6_HUMANBioGRID22974441 details
FGFR1_HUMANITK_HUMANBioGRID22974441 details
FGFR1_HUMANNCK1_HUMANBioGRID22974441 details
FGFR1_HUMANVAV_HUMANBioGRID22974441 details
FGFR1_HUMANKS6A3_HUMANBioGRID24141780 details
FGFR1_HUMANFGF3_HUMANBioGRID, HPRD18199118 8663044 details
FGFR1_HUMANFGF5_HUMANBioGRID, HPRD18199118 8386828 details
FGFR1_HUMANFGF10_HUMANBioGRID18199118 details
FGFR1_HUMANFGF17_HUMANBioGRID, HPRD10751172 18199118 details
FGFR1_HUMANKS6A1_HUMANBioGRID, HPRD15117958 19261810 details
FGFR1_HUMANSLAP1_HUMANBioGRID, HPRD15117958 details
FGFR1_HUMANP85B_HUMANBioGRID, HPRD15117958 details
FGFR1_HUMAN3BP2_HUMANBioGRID, HPRD15117958 details
FGFR1_HUMANNCK2_HUMANBioGRID, HPRD15117958 details
FGFR1_HUMANTNS2_HUMANBioGRID, HPRD15117958 details
FGFR1_HUMANRTN1_HUMANBioGRID15117958 details
FGFR1_HUMANRTN3_HUMANBioGRID, HPRD15117958 details
FGFR1_HUMANNECT1_HUMANBioGRID22955284 details
FGFR1_HUMANEPHA4_HUMANBioGRID, HPRD16365308 18790757 details
FGFR1_HUMANYES_HUMANBioGRID16631103 details
FGFR1_HUMANL1CAM_HUMANBioGRID18222703 23212305 details
FGFR1_HUMANACK1_HUMANBioGRID25945695 details
FGFR1_HUMANPDP1_HUMANBioGRID24486017 details
FGFR1_HUMANRASA1_HUMANBioGRID8321198 details
FGFR1_HUMANZMYM2_HUMANBioGRID10480903 10935490 details
FGFR1_HUMANSHC1_HUMANBioGRID, HPRD18022941 7514169 7559490 details
FGFR1_HUMANPTN1_HUMANBioGRID25760602 details
FGFR1_HUMANFBX7_HUMANBioGRID27503909 details
FGFR1_HUMANRARA_HUMANBioGRID22539306 details
FGFR1_HUMANPGFRB_HUMANBioGRID19339244 details
FGFR1_HUMANPDK1_HUMANBioGRID22195962 details
FGFR1_HUMANITB3_HUMANBioGRID27371729 details
FGFR1_HUMANERBB2_HUMANBioGRID30898150 details
FGFR1_HUMANLDHA_HUMANBioGRID32572027 details
FGFR1_HUMANATG5_HUMANIntAct17353931 details
FGFR1_HUMANCTNB1_HUMANBioGRID, IntAct11401320 18302981 25241761 details
FGFR1_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
FGFR1_HUMANSOS1_HUMANBioGRID, HPRD, IntAct25241761 9480847 details
FGFR1_HUMANCD44_HUMANBioGRID, IntAct15597342 28514442 details
FGFR1_HUMANFGF19_HUMANDIP19706524 details
FGFR1_HUMANCDC37_HUMANBioGRID, IntAct18022941 31980649 details
FGFR1_HUMANIMB1_HUMANBioGRID, HPRD11257130 details
FGFR1_HUMANSTAT3_HUMANBioGRID20388777 details
FGFR1_HUMANJAK2_HUMANBioGRID20388777 details
FGFR1_HUMANSRC_HUMANBioGRID18022941 20388777 details
FGFR1_HUMAN2AAB_HUMANBioGRID17540176 details
FGFR1_HUMANHS90A_HUMANBioGRID18022941 21745565 22939624 details
FGFR1_HUMANAKT1_HUMANBioGRID25945695 details
FGFR1_HUMANFLRT1_HUMANBioGRID20421966 details
FGFR1_HUMANCADH2_HUMANBioGRID17005551 18302981 details
FGFR1_HUMANOPCM_HUMANBioGRID22585860 details
FGFR1_HUMANS100B_HUMANBioGRID21693575 details
FGFR1_HUMANRAGE_HUMANBioGRID21693575 details
FGFR1_HUMANCAD11_HUMANBioGRID18302981 details
FGFR1_HUMANTGBR3_HUMANBioGRID24216509 details
FGFR1_HUMANI17RD_HUMANBioGRID, HPRD12604616 16603339 details
FGFR1_HUMANCRKL_HUMANBioGRID19307307 details
FGFR1_HUMANACTS_HUMANBioGRID18022941 19261810 details
FGFR1_HUMANRAB1A_HUMANBioGRID18022941 details
FGFR1_HUMANSTX12_HUMANBioGRID18022941 details
FGFR1_HUMANAFAP1_HUMANBioGRID18022941 details
FGFR1_HUMANBAX_HUMANBioGRID18022941 details
FGFR1_HUMANGAB1_HUMANBioGRID18022941 details
FGFR1_HUMANPTN11_HUMANBioGRID18022941 details
FGFR1_HUMANRXRA_HUMANBioGRID22539306 details
FGFR1_HUMANH33_HUMANBioGRID22539306 details
FGFR1_HUMANTY3H_HUMANBioGRID22539306 details
FGFR1_HUMANUBC_HUMANBioGRID20038681 details
FGFR1_HUMANSHE_HUMANBioGRID12181353 details
FGFR1_HUMANGNAI1_HUMANBioGRID29520106 details
FGFR1_HUMANRIN1_HUMANBioGRID12783862 details
FGFR1_HUMANGRB2_HUMANHPRD9480847 details
FGFR1_HUMANMMP2_HUMANHPRD8692946 details
FGFR1_HUMANFGF7_HUMANHPRD8663044 details
FGFR1_HUMANNRP1_HUMANHPRD15695515 details
FGFR1_HUMANFLRT3_HUMANHPRD16440004 details