Entity Details

Primary name FGF3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11487
EntryNameFGF3_HUMAN
FullNameFibroblast growth factor 3
TaxID9606
Evidenceevidence at protein level
Length239
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesFGF3

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001934 positive regulation of protein phosphorylation
GO:0005104 fibroblast growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009653 anatomical structure morphogenesis
GO:0009887 animal organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0030154 cell differentiation
GO:0030334 regulation of cell migration
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0055026 negative regulation of cardiac muscle tissue development

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR002209 Fibroblast growth factor familyFamilyFamily
IPR008996 Cytokine IL1/FGFFamilyHomologous superfamily
IPR028232 Fibroblast growth factor 3FamilyFamily

Diseases

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Disease IDSourceNameDescription
610706 OMIMDeafness with labyrinthine aplasia, microtia and microdontia (LAMM)Unique autosomal recessive syndrome characterized by type I microtia, microdontia, and profound congenital deafness associated with a complete absence of inner ear structures (Michel aplasia). The disease is caused by variants affecting the gene represented in this entry.