Entity Details

Primary name GLNA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15104
EntryNameGLNA_HUMAN
FullNameGlutamine synthetase
TaxID9606
Evidenceevidence at protein level
Length373
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesGLUL

GO terms

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GOName
GO:0001504 neurotransmitter uptake
GO:0001525 angiogenesis
GO:0004356 glutamate-ammonia ligase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006538 glutamate catabolic process
GO:0006542 glutamine biosynthetic process
GO:0008283 cell population proliferation
GO:0009064 glutamine family amino acid metabolic process
GO:0010594 regulation of endothelial cell migration
GO:0018345 protein palmitoylation
GO:0019706 protein-cysteine S-palmitoyltransferase activity
GO:0042254 ribosome biogenesis
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0070062 extracellular exosome
GO:1903670 regulation of sprouting angiogenesis
GO:1904749 regulation of protein localization to nucleolus

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Microsome
Mitochondrion

Domains

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DomainNameCategoryType
IPR008146 Glutamine synthetase, catalytic domainDomainDomain
IPR008147 Glutamine synthetase, beta-Grasp domainDomainDomain
IPR014746 Glutamine synthetase/guanido kinase, catalytic domainFamilyHomologous superfamily
IPR027302 Glutamine synthetase, N-terminal conserved siteSiteConserved site
IPR027303 Glutamine synthetase, glycine-rich siteSiteConserved site
IPR036651 Glutamine synthetase, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00082 PegvisomantDrugbankbiotech
DB00130 L-GlutamineDrugbanksmall molecule
DB00134 MethionineDrugbanksmall molecule
DB00142 Glutamic acidDrugbanksmall molecule
DB00466 PicrotoxinDrugbanksmall molecule
DB01119 DiazoxideDrugbanksmall molecule
DB01212 CeftriaxoneDrugbanksmall molecule
DB06774 CapsaicinDrugbanksmall molecule
DB08794 Ethyl biscoumacetateSwissprotsmall molecule
DB11118 AmmoniaSwissprotsmall molecule

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
GLNA_HUMANSKIL_HUMANBioGRID, HPRD, MINT15231748 details
GLNA_HUMANPKHF2_HUMANBioGRID, HPRD, IntAct16189514 details
GLNA_HUMANGLNA_HUMANBioGRID, HPRD, IntAct16189514 19447967 21988832 25416956 25502805 31515488 details
GLNA_HUMANNUD18_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
GLNA_HUMANRBBP6_HUMANBioGRID, IntAct18624398 details
GLNA_HUMANC8AP2_HUMANBioGRID, IntAct20936779 details
GLNA_HUMANHIPK1_HUMANBioGRID, IntAct20936779 details
GLNA_HUMANHIPK3_HUMANBioGRID, IntAct20936779 details
GLNA_HUMANUBC9_HUMANBioGRID, IntAct20936779 details
GLNA_HUMANPIAS3_HUMANBioGRID, IntAct20936779 details
GLNA_HUMANPIAS2_HUMANBioGRID, IntAct20936779 details
GLNA_HUMANPIAS1_HUMANBioGRID, IntAct20936779 details
GLNA_HUMANNU5M_HUMANBioGRID, IntAct20936779 details
GLNA_HUMANNFKB1_HUMANBioGRID, IntAct21988832 details
GLNA_HUMANRABEK_HUMANBioGRID, IntAct21988832 details
GLNA_HUMANCP39A_HUMANBioGRID, IntAct21988832 details
GLNA_HUMANAP2A_HUMANIntAct24835590 details
GLNA_HUMANATTY_HUMANBioGRID, IntAct25910212 details
GLNA_HUMAN5HT2A_HUMANDIP, HPRD16537434 details
GLNA_HUMANRHOJ_HUMANDIP30158707 details
GLNA_HUMANPCNA_HUMANUniProt26030842 details
GLNA_HUMANNAL12_HUMANI2D32226298 details
GLNA_HUMANPPARD_HUMANBioGRID15604093 details
GLNA_HUMANHCD2_HUMANBioGRID22496890 details
GLNA_HUMANCRBN_HUMANBioGRID26990986 28320958 details
GLNA_HUMANEP300_HUMANBioGRID26990986 details
GLNA_HUMANHLAB_HUMANIntAct17353931 details
GLNA_HUMANDISC1_HUMANIntAct31413325 details
GLNA_HUMANCHP3_HUMANIntAct31413325 details
GLNA_HUMANZNRF1_HUMANBioGRID20107048 details
GLNA_HUMANTERA_HUMANBioGRID28320958 details
GLNA_HUMANNPL4_HUMANBioGRID28320958 details
GLNA_HUMANUFD1_HUMANBioGRID28320958 details
GLNA_HUMANDYL1_HUMANHPRD14760703 details