Entity Details

Primary name NDKA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15531
EntryNameNDKA_HUMAN
FullNameNucleoside diphosphate kinase A
TaxID9606
Evidenceevidence at protein level
Length152
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesNME1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0004536 deoxyribonuclease activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0006183 GTP biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006897 endocytosis
GO:0007595 lactation
GO:0008285 negative regulation of cell population proliferation
GO:0010629 negative regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0014075 response to amine
GO:0015949 nucleobase-containing small molecule interconversion
GO:0016020 membrane
GO:0019215 intermediate filament binding
GO:0019899 enzyme binding
GO:0021766 hippocampus development
GO:0030154 cell differentiation
GO:0032587 ruffle membrane
GO:0033574 response to testosterone
GO:0035690 cellular response to drug
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043015 gamma-tubulin binding
GO:0043024 ribosomal small subunit binding
GO:0043388 positive regulation of DNA binding
GO:0048471 perinuclear region of cytoplasm
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051591 response to cAMP
GO:0070062 extracellular exosome
GO:0071333 cellular response to glucose stimulus
GO:0071398 cellular response to fatty acid

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001564 Nucleoside diphosphate kinaseFamilyFamily
IPR023005 Nucleoside diphosphate kinase, active siteSiteActive site
IPR034907 Nucleoside diphosphate kinase-like domainDomainDomain
IPR036850 Nucleoside diphosphate kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00300 Tenofovir disoproxilDrugbanksmall molecule
DB00709 LamivudineDrugbanksmall molecule
DB00718 Adefovir dipivoxilDrugbanksmall molecule
DB00787 AcyclovirDrugbanksmall molecule
DB01262 DecitabineDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB02181 2'-Deoxyguanosine-5'-TriphosphateDrugbanksmall molecule
DB02345 SelenocysteineDrugbanksmall molecule
DB02569 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-DiphosphateDrugbanksmall molecule
DB02607 Adenosine Phosphonoacetic AcidDrugbanksmall molecule
DB02887 Stavudine triphosphateDrugbanksmall molecule
DB03103 Thymidine-5'- DiphosphateDrugbanksmall molecule
DB03491 2'-Deoxyguanosine-5'-DiphosphateDrugbanksmall molecule
DB04068 2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphateDrugbanksmall molecule
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule
DB04366 3'-Deoxy 3'-Amino Adenosine-5'-DiphosphateDrugbanksmall molecule
DB04542 Zidovudine diphosphateDrugbanksmall molecule
DB08934 SofosbuvirDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB09299 Tenofovir alafenamideDrugbanksmall molecule
DB14126 TenofovirDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
NDKA_HUMANTERF1_HUMANBioGRID, HPRD, MINT11701125 9480811 details
NDKA_HUMANNTAQ1_HUMANBioGRID, HPRD, IntAct16189514 19060904 31515488 32296183 details
NDKA_HUMANNDKM_HUMANBioGRID, HPRD, IntAct16189514 25416956 27499296 31515488 32296183 details
NDKA_HUMANRPAC1_HUMANBioGRID, HPRD, IntAct16189514 21988832 25416956 31515488 32296183 details
NDKA_HUMANGORS2_HUMANBioGRID, HPRD, IntAct16189514 details
NDKA_HUMANNDK3_HUMANBioGRID, HPRD, IntAct11042679 16189514 25416956 28514442 31515488 details
NDKA_HUMANNDKA_HUMANBioGRID, HPRD, IntAct10602478 11835509 16189514 17314099 18815136 25416956 25502805 25910212 31515488 31980649 32296183 8245015 8810265 details
NDKA_HUMANPRUN1_HUMANBioGRID, HPRD, IntAct10602478 11687967 details
NDKA_HUMANSTRAP_HUMANBioGRID, IntAct17314099 details
NDKA_HUMANNDKB_HUMANBioGRID, IntAct17314099 21988832 22863883 31980649 details
NDKA_HUMANNIF3L_HUMANBioGRID, IntAct19060904 details
NDKA_HUMANFXR2_HUMANBioGRID, IntAct, MINT19060904 21653829 31515488 details
NDKA_HUMANSOX30_HUMANBioGRID, IntAct21988832 details
NDKA_HUMANCCND3_HUMANBioGRID, IntAct21988832 details
NDKA_HUMANSMRD1_HUMANBioGRID, IntAct21988832 details
NDKA_HUMANTNPO2_HUMANBioGRID, IntAct25416956 details
NDKA_HUMANPCLI1_HUMANBioGRID, IntAct25416956 details
NDKA_HUMANSR1IP_HUMANBioGRID, IntAct25416956 details
NDKA_HUMANTNPO3_HUMANBioGRID, IntAct32296183 details
NDKA_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
NDKA_HUMANNTF2_HUMANBioGRID, IntAct32296183 details
NDKA_HUMANAURKA_HUMANBioGRID, HPRD12490715 details
NDKA_HUMANITB1_HUMANBioGRID11919189 details
NDKA_HUMANRAC1_HUMANBioGRID11274357 details
NDKA_HUMANMIF_HUMANBioGRID, HPRD18815136 details
NDKA_HUMANPTEN_HUMANBioGRID26561776 32249768 details
NDKA_HUMANFBX24_HUMANBioGRID25582197 details
NDKA_HUMANRORA_HUMANHPRD8858107 details
NDKA_HUMANMCF2_HUMANUniProt18470881 details
NDKA_HUMANTGM2_HUMANMINT19619546 details
NDKA_HUMANDYN1_HUMANDIP20713695 details
NDKA_HUMANFXR1_HUMANMINT21653829 details
NDKA_HUMANSET_HUMANBioGRID, HPRD12628186 details
NDKA_HUMANRAD_HUMANBioGRID, HPRD10611312 11280768 details
NDKA_HUMANTIAM1_HUMANBioGRID, HPRD11274357 details
NDKA_HUMANGATA1_HUMANBioGRID16631833 details
NDKA_HUMANHDAC5_HUMANBioGRID21081666 details
NDKA_HUMANKAT2A_HUMANBioGRID25582197 details
NDKA_HUMANAPEX1_HUMANHPRD12524539 details
NDKA_HUMANKSR1_HUMANHPRD12105213 details