Entity Details

Primary name DPEP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16444
EntryNameDPEP1_HUMAN
FullNameDipeptidase 1
TaxID9606
Evidenceevidence at protein level
Length411
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesDPEP1

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0006629 lipid metabolic process
GO:0006691 leukotriene metabolic process
GO:0006749 glutathione metabolic process
GO:0006751 glutathione catabolic process
GO:0006954 inflammatory response
GO:0008235 metalloexopeptidase activity
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
GO:0016324 apical plasma membrane
GO:0016999 antibiotic metabolic process
GO:0030054 cell junction
GO:0030336 negative regulation of cell migration
GO:0030593 neutrophil chemotaxis
GO:0031225 anchored component of membrane
GO:0031528 microvillus membrane
GO:0034235 GPI anchor binding
GO:0035690 cellular response to drug
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045177 apical part of cell
GO:0046222 aflatoxin metabolic process
GO:0050667 homocysteine metabolic process
GO:0070062 extracellular exosome
GO:0070573 metallodipeptidase activity
GO:0071277 cellular response to calcium ion
GO:0071732 cellular response to nitric oxide
GO:0072340 cellular lactam catabolic process
GO:0072341 modified amino acid binding

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000180 Membrane dipeptidase, active siteSiteActive site
IPR008257 Peptidase M19FamilyFamily
IPR028536 Dipeptidase 1FamilyFamily
IPR032466 Metal-dependent hydrolaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01597 CilastatinDrugbanksmall molecule
DB01598 ImipenemDrugbanksmall molecule
DB06211 DoripenemDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
DPEP1_HUMANKBP_HUMANBioGRID, HPRD, IntAct16189514 details
DPEP1_HUMANAPBP2_HUMANBioGRID, IntAct25416956 details
DPEP1_HUMANDPEP1_HUMANBioGRID, HPRD12144777 2137335 details