Entity Details

Primary name HXK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19367
EntryNameHXK1_HUMAN
FullNameHexokinase-1
TaxID9606
Evidenceevidence at protein level
Length917
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesHK1

GO terms

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GOName
GO:0001678 cellular glucose homeostasis
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005524 ATP binding
GO:0005536 glucose binding
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0006002 fructose 6-phosphate metabolic process
GO:0006013 mannose metabolic process
GO:0006096 glycolytic process
GO:0006954 inflammatory response
GO:0008865 fructokinase activity
GO:0019158 mannokinase activity
GO:0032731 positive regulation of interleukin-1 beta production
GO:0042834 peptidoglycan binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0046835 carbohydrate phosphorylation
GO:0047931 glucosamine kinase activity
GO:0051156 glucose 6-phosphate metabolic process
GO:0061621 canonical glycolysis
GO:0072655 establishment of protein localization to mitochondrion
GO:0072656 maintenance of protein location in mitochondrion

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR001312 HexokinaseFamilyFamily
IPR019807 Hexokinase, binding siteSiteBinding site
IPR022672 Hexokinase, N-terminalDomainDomain
IPR022673 Hexokinase, C-terminalDomainDomain
IPR043129 ATPase, nucleotide binding domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01914 D-glucoseSwissprotsmall molecule
DB02007 alpha-D-glucose 6-phosphateDrugbanksmall molecule
DB02379 Beta-D-GlucoseDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB06266 LonidamineDrugbanksmall molecule
DB09341 Dextrose, unspecified formSwissprotsmall molecule
DB09502 Fludeoxyglucose (18F)Swissprotsmall molecule