Entity Details

Primary name GGT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19440
EntryNameGGT1_HUMAN
FullNameGlutathione hydrolase 1 proenzyme
TaxID9606
Evidenceevidence at protein level
Length569
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesGGT1

GO terms

Show/Hide Table
GOName
GO:0000048 peptidyltransferase activity
GO:0002682 regulation of immune system process
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0002951 leukotriene-C(4) hydrolase
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0006520 cellular amino acid metabolic process
GO:0006536 glutamate metabolic process
GO:0006631 fatty acid metabolic process
GO:0006691 leukotriene metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006751 glutathione catabolic process
GO:0007283 spermatogenesis
GO:0016021 integral component of membrane
GO:0019344 cysteine biosynthetic process
GO:0031179 peptide modification
GO:0031638 zymogen activation
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0034612 response to tumor necrosis factor
GO:0036374 glutathione hydrolase activity
GO:0046222 aflatoxin metabolic process
GO:0050727 regulation of inflammatory response
GO:0070062 extracellular exosome
GO:0102953 hypoglycin A gamma-glutamyl transpeptidase activity
GO:0103068 leukotriene C4 gamma-glutamyl transferase activity
GO:1901750 leukotriene D4 biosynthetic process

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000101 Gamma-glutamyltranspeptidaseFamilyFamily
IPR029055 Nucleophile aminohydrolases, N-terminalFamilyHomologous superfamily
IPR043137 Gamma-glutamyltranspeptidase, small subunitFamilyHomologous superfamily
IPR043138 Gamma-glutamyltranspeptidase, large subunit, C-terminal domainFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule