Entity Details

Primary name ITAL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20701
EntryNameITAL_HUMAN
FullNameIntegrin alpha-L
TaxID9606
Evidenceevidence at protein level
Length1170
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesITGAL

GO terms

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GOName
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0005886 plasma membrane
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0016020 membrane
GO:0016032 viral process
GO:0030198 extracellular matrix organization
GO:0030369 ICAM-3 receptor activity
GO:0034687 integrin alphaL-beta2 complex
GO:0035579 specific granule membrane
GO:0035683 memory T cell extravasation
GO:0043113 receptor clustering
GO:0043312 neutrophil degranulation
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0050776 regulation of immune response
GO:0050839 cell adhesion molecule binding
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome
GO:0098609 cell-cell adhesion

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR002035 von Willebrand factor, type ADomainDomain
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00095 EfalizumabDrugbankbiotech
DB00098 Antithymocyte immunoglobulin (rabbit)Drugbankbiotech
DB00227 LovastatinDrugbanksmall molecule
DB00641 SimvastatinDrugbanksmall molecule
DB01098 RosuvastatinDrugbanksmall molecule
DB02177 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)PiperazineDrugbanksmall molecule
DB03932 LFA703Drugbanksmall molecule
DB04724 (S)-2-((S)-3-isobutyl-2,5-dioxo-4-quinolin-3-ylmethyl-[1,4]diazepan-1yl)-N-methyl-3-naphtalen-2-yl-propionamideDrugbanksmall molecule
DB06972 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrileDrugbanksmall molecule
DB07486 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)anilineDrugbanksmall molecule
DB08860 PitavastatinDrugbanksmall molecule
DB11611 LifitegrastDrugbanksmall molecule