Entity Details

Primary name EDNRA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25101
EntryNameEDNRA_HUMAN
FullNameEndothelin-1 receptor
TaxID9606
Evidenceevidence at protein level
Length427
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesEDNRA

GO terms

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GOName
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004962 endothelin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007507 heart development
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0008217 regulation of blood pressure
GO:0008283 cell population proliferation
GO:0010827 regulation of glucose transmembrane transport
GO:0014032 neural crest cell development
GO:0014824 artery smooth muscle contraction
GO:0042310 vasoconstriction
GO:0048484 enteric nervous system development
GO:0060322 head development

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000499 Endothelin receptor familyFamilyFamily
IPR002175 Endothelin receptor AFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00559 BosentanDrugbanksmall molecule
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB04674 2-HYDROXY-3,5-DIIODOBENZOIC ACIDDrugbanksmall molecule
DB04883 DarusentanDrugbanksmall molecule
DB05290 SPP 301Drugbanksmall molecule
DB05367 Actelion-1Drugbanksmall molecule
DB06199 AtrasentanDrugbanksmall molecule
DB06268 SitaxentanDrugbanksmall molecule
DB06403 AmbrisentanDrugbanksmall molecule
DB06460 EnrasentanDrugbanksmall molecule
DB06558 TezosentanDrugbanksmall molecule
DB06677 ClazosentanDrugbanksmall molecule
DB08932 MacitentanDrugbanksmall molecule
DB12548 SparsentanDrugbanksmall molecule