Entity Details

Primary name PSA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25787
EntryNamePSA2_HUMAN
FullNameProteasome subunit alpha type-2
TaxID9606
Evidenceevidence at protein level
Length234
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesPSMA2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0000932 P-body
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004175 endopeptidase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0006521 regulation of cellular amino acid metabolic process
GO:0009615 response to virus
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016579 protein deubiquitination
GO:0019773 proteasome core complex, alpha-subunit complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034774 secretory granule lumen
GO:0036388 pre-replicative complex assembly
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043312 neutrophil degranulation
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000426 Proteasome alpha-subunit, N-terminal domainDomainDomain
IPR001353 Proteasome, subunit alpha/betaFamilyFamily
IPR023332 Proteasome alpha-type subunitFamilyFamily
IPR029055 Nucleophile aminohydrolases, N-terminalFamilyHomologous superfamily
IPR034644 Proteasome subunit alpha2FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB08515 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDEDrugbanksmall molecule

Interactions

92 interactions

InteractorPartnerSourcesPublicationsLink
PSA2_HUMANPSA7_HUMANBioGRID, HPRD, IntAct, MINT12376572 15225636 15887188 17948026 19193609 21900206 22863883 22939629 26344197 details
PSA2_HUMANPSB2_HUMANBioGRID, IntAct12376572 15887188 17948026 19193609 22863883 22939629 26344197 28514442 details
PSA2_HUMANPSA4_HUMANBioGRID, HPRD, IntAct, MINT12376572 14733938 15225636 15887188 17948026 19193609 22863883 22939629 26344197 28292943 31114588 9311996 details
PSA2_HUMANPSA2_HUMANBioGRID12376572 15887188 28292943 details
PSA2_HUMANPRS8_HUMANBioGRID19193609 26344197 28292943 details
PSA2_HUMANPSA1_HUMANBioGRID, DIP, HPRD, IntAct12376572 14733938 15225636 15887188 19193609 21988832 22863883 22939629 25599644 26186194 26344197 28514442 29568061 29636472 32296183 details
PSA2_HUMANPSA6_HUMANBioGRID, HPRD, IntAct, MINT12376572 14733938 15887188 16759355 17948026 19193609 22863883 22939629 26344197 27465334 details
PSA2_HUMANPSA3_HUMANBioGRID, HPRD, IntAct12376572 14733938 15225636 15887188 19193609 22863883 22939629 26344197 9311996 details
PSA2_HUMANPSB5_HUMANBioGRID, HPRD, IntAct14733938 15887188 19193609 20980621 22863883 22939629 24121268 26344197 details
PSA2_HUMANHOME3_HUMANBioGRID, IntAct21988832 details
PSA2_HUMANIKBA_HUMANBioGRID16098527 details
PSA2_HUMANUBQL2_HUMANBioGRID12972570 details
PSA2_HUMANFBX7_HUMANBioGRID27497298 27503909 details
PSA2_HUMANPSB10_HUMANBioGRID, IntAct15887188 17948026 19193609 20937868 details
PSA2_HUMANPSMG3_HUMANBioGRID17189198 19193609 details
PSA2_HUMANPSB6_HUMANBioGRID, IntAct12376572 15887188 19193609 22863883 22939629 26344197 details
PSA2_HUMANPSB4_HUMANBioGRID, IntAct12376572 15660529 15887188 19193609 22863883 22939629 26186194 26344197 28514442 details
PSA2_HUMANHLAC_HUMANIntAct17353931 details
PSA2_HUMANUCHL5_HUMANBioGRID, IntAct, UniProt18922472 19193609 19490896 26344197 details
PSA2_HUMANPRS6B_HUMANBioGRID19193609 22939629 26344197 details
PSA2_HUMANPSD12_HUMANBioGRID19193609 22939629 26344197 details
PSA2_HUMANPSDE_HUMANBioGRID17323924 19193609 24121268 26344197 27428775 28821611 details
PSA2_HUMANPSME2_HUMANBioGRID19193609 22939629 details
PSA2_HUMANABCE1_HUMANBioGRID25659154 details
PSA2_HUMANPSB1_HUMANBioGRID, IntAct12376572 15887188 19193609 22863883 22939629 26344197 28514442 details
PSA2_HUMANPSA5_HUMANBioGRID, IntAct12376572 15887188 19193609 22863883 22939629 26344197 details
PSA2_HUMANPSB7_HUMANBioGRID, IntAct12376572 15887188 19193609 22863883 22939629 26186194 26344197 28514442 details
PSA2_HUMANFKBP8_HUMANBioGRID17573772 details
PSA2_HUMANPSD13_HUMANBioGRID19193609 22939629 26344197 details
PSA2_HUMANPSB3_HUMANBioGRID, IntAct12376572 15887188 19193609 22863883 22939629 26344197 28514442 details
PSA2_HUMANCUL1_HUMANBioGRID, IntAct16759355 19193609 21145461 details
PSA2_HUMANBIP_HUMANBioGRID19193609 details
PSA2_HUMANIKKE_HUMANIntAct17353931 details
PSA2_HUMANSKP1_HUMANBioGRID, IntAct19193609 27705803 details
PSA2_HUMANPRS10_HUMANBioGRID, DIP19193609 26344197 27342858 29636472 details
PSA2_HUMANPSMD1_HUMANBioGRID19193609 22939629 26344197 details
PSA2_HUMANPSMF1_HUMANBioGRID19193609 details
PSA2_HUMANUBE3C_HUMANBioGRID19193609 details
PSA2_HUMANTERA_HUMANBioGRID19193609 22939629 details
PSA2_HUMANTCPG_HUMANBioGRID19193609 details
PSA2_HUMANPSB8_HUMANBioGRID, IntAct15887188 19193609 20937868 22863883 22939629 26344197 31114588 details
PSA2_HUMANNDKB_HUMANBioGRID, IntAct17353931 details
PSA2_HUMANRD23A_HUMANBioGRID19013454 details
PSA2_HUMANPSD11_HUMANBioGRID19193609 22939629 24121268 details
PSA2_HUMANPSMD8_HUMANBioGRID19193609 22939629 26344197 details
PSA2_HUMANADRM1_HUMANBioGRID19193609 26344197 details
PSA2_HUMANUBP14_HUMANBioGRID19193609 30425250 31901637 details
PSA2_HUMANPSME1_HUMANBioGRID19193609 31114588 details
PSA2_HUMANPSME4_HUMANBioGRID19193609 22863883 details
PSA2_HUMANUBP7_HUMANBioGRID19193609 details
PSA2_HUMANRBP10_HUMANBioGRID, IntAct27173435 unassigned1312 details
PSA2_HUMANPSMD3_HUMANBioGRID19193609 22939629 26344197 details
PSA2_HUMANPSMG2_HUMANBioGRID19193609 26344197 details
PSA2_HUMANRD23B_HUMANBioGRID19193609 details
PSA2_HUMANSEML_HUMANBioGRID18775730 details
PSA2_HUMANPRS7_HUMANBioGRID19193609 22939629 26344197 details
PSA2_HUMANPSMD7_HUMANBioGRID19193609 22939629 26344197 details
PSA2_HUMANPSMD4_HUMANBioGRID, DIP, MINT16990800 19193609 22939629 24121268 26344197 30479383 details
PSA2_HUMANPRS4_HUMANBioGRID15837734 19193609 24121268 26344197 details
PSA2_HUMANPSMD2_HUMANBioGRID19193609 22939629 26344197 31114588 details
PSA2_HUMANUBE3A_HUMANBioGRID22645313 29426014 30257870 details
PSA2_HUMANPSB9_HUMANBioGRID, IntAct15887188 19193609 20937868 26186194 28514442 30833792 details
PSA2_HUMANATG5_HUMANIntAct17353931 details
PSA2_HUMANDDI2_HUMANBioGRID19193609 details
PSA2_HUMANCRBN_HUMANBioGRID23026050 details
PSA2_HUMANCDC5L_HUMANBioGRID15660529 details
PSA2_HUMANFBXW7_HUMANBioGRID19193609 29346117 details
PSA2_HUMANEF1A1_HUMANBioGRID19193609 details
PSA2_HUMANPSMG1_HUMANBioGRID17189198 19193609 details
PSA2_HUMANPSMD6_HUMANBioGRID, IntAct17353931 19193609 22939629 26344197 details
PSA2_HUMANTCPH_HUMANBioGRID19193609 details
PSA2_HUMANTRAF6_HUMANIntAct17353931 details
PSA2_HUMANCAND1_HUMANBioGRID19193609 details
PSA2_HUMAN3MG_HUMANIntAct17353931 details
PSA2_HUMANPAAF1_HUMANBioGRID19193609 details
PSA2_HUMANPOMP_HUMANBioGRID10973495 17189198 details
PSA2_HUMANNEDD8_HUMANBioGRID16503656 details
PSA2_HUMANPRS6A_HUMANBioGRID19193609 22939629 26344197 details
PSA2_HUMANUBB_HUMANBioGRID19193609 details
PSA2_HUMANRBX1_HUMANBioGRID19193609 details
PSA2_HUMANVHL_HUMANIntAct17353931 details
PSA2_HUMANEIF1B_HUMANIntAct17353931 details
PSA2_HUMANPEX5_HUMANBioGRID28724525 details
PSA2_HUMANTNIK_HUMANIntAct17353931 details
PSA2_HUMANSEM1_HUMANBioGRID18775730 details
PSA2_HUMANPRP19_HUMANBioGRID15660529 details
PSA2_HUMANHSP7C_HUMANBioGRID19193609 details
PSA2_HUMANPAK2_HUMANIntAct17353931 details
PSA2_HUMANPLK1_HUMANBioGRID11205743 details
PSA2_HUMANTERF1_HUMANBioGRID20811636 details
PSA2_HUMANBCAR3_HUMANIntAct17353931 details
PSA2_HUMANHS90B_HUMANBioGRID19193609 details