Entity Details

Primary name 5HT1B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28222
EntryName5HT1B_HUMAN
FullName5-hydroxytryptamine receptor 1B
TaxID9606
Evidenceevidence at protein level
Length390
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesHTR1B

GO terms

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GOName
GO:0002031 G protein-coupled receptor internalization
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0014053 negative regulation of gamma-aminobutyric acid secretion
GO:0014059 regulation of dopamine secretion
GO:0014063 negative regulation of serotonin secretion
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0032229 negative regulation of synaptic transmission, GABAergic
GO:0035690 cellular response to drug
GO:0042220 response to cocaine
GO:0042310 vasoconstriction
GO:0042756 drinking behavior
GO:0044305 calyx of Held
GO:0045471 response to ethanol
GO:0046849 bone remodeling
GO:0050795 regulation of behavior
GO:0051378 serotonin binding
GO:0051385 response to mineralocorticoid
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0071312 cellular response to alkaloid
GO:0071502 cellular response to temperature stimulus
GO:0098666 G protein-coupled serotonin receptor complex
GO:0099056 integral component of presynaptic membrane
GO:0099154 serotonergic synapse
GO:0099171 presynaptic modulation of chemical synaptic transmission
GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR002147 5-Hydroxytryptamine 1B receptorFamilyFamily
IPR002231 5-hydroxytryptamine receptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00216 EletriptanDrugbanksmall molecule
DB00246 ZiprasidoneDrugbanksmall molecule
DB00247 MethysergideDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00315 ZolmitriptanDrugbanksmall molecule
DB00320 DihydroergotamineDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00571 PropranololDrugbanksmall molecule
DB00589 LisurideDrugbanksmall molecule
DB00669 SumatriptanDrugbanksmall molecule
DB00696 ErgotamineDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00904 OndansetronDrugbanksmall molecule
DB00918 AlmotriptanDrugbanksmall molecule
DB00952 NaratriptanDrugbanksmall molecule
DB00953 RizatriptanDrugbanksmall molecule
DB00960 PindololDrugbanksmall molecule
DB00998 FrovatriptanDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01359 PenbutololDrugbanksmall molecule
DB01392 YohimbineDrugbanksmall molecule
DB04884 DapoxetineDrugbanksmall molecule
DB06096 NXN-188Drugbanksmall molecule
DB06153 PizotifenDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB08807 BopindololDrugbanksmall molecule
DB09068 VortioxetineDrugbanksmall molecule
DB09304 SetiptilineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule