Entity Details

Primary name OAS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29728
EntryNameOAS2_HUMAN
FullName2'-5'-oligoadenylate synthase 2
TaxID9606
Evidenceevidence at protein level
Length719
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesOAS2

GO terms

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GOName
GO:0001730 2'-5'-oligoadenylate synthetase activity
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006139 nucleobase-containing compound metabolic process
GO:0006401 RNA catabolic process
GO:0009615 response to virus
GO:0016020 membrane
GO:0032728 positive regulation of interferon-beta production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042742 defense response to bacterium
GO:0043231 intracellular membrane-bounded organelle
GO:0045071 negative regulation of viral genome replication
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060700 regulation of ribonuclease activity
GO:0070106 interleukin-27-mediated signaling pathway
GO:1903487 regulation of lactation

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR002934 Polymerase, nucleotidyl transferase domainDomainDomain
IPR006116 2-5OAS/ClassI-CCAase, nucleotidyltransferase domainDomainDomain
IPR006117 2-5-oligoadenylate synthetase, C-terminal conserved siteSiteConserved site
IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminalDomainDomain
IPR026774 2'-5'-oligoadenylate synthaseFamilyFamily
IPR043518 2-5-oligoadenylate synthetase, N-terminal conserved siteSiteConserved site
IPR043519 Nucleotidyltransferase superfamilyFamilyHomologous superfamily

Diseases

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Interactions

5 interactions